本文選題：低能量光療　切入點：光生物調(diào)節(jié)作用　出處：《電子科技大學(xué)》2017年碩士論文

【摘要】：光生物調(diào)節(jié)作用(Photobiomodulation,PBM)也稱為低水平(或低能量)激光(或光)治療(low-level laser or light therapy,LLLT),今年是發(fā)現(xiàn)低能量的光照有光生物調(diào)節(jié)作用的第50年,由于低能量光療的生物調(diào)節(jié)作用十分廣泛,且有非侵入性的優(yōu)勢,所以廣泛應(yīng)用于臨床研究中,包括減輕疼痛,加快傷口愈合,神經(jīng)損傷修復(fù)與再生,增加組織血流量,改善焦慮抑郁狀態(tài),治療帕金森,視網(wǎng)膜疾病等。然而在眾多研究過程中,PBM仍巨有較大爭議。主要存在兩個問題:一,PBM的機制不被完全了解,二,在不同的治療中具體的參數(shù)不統(tǒng)一,如波長,能量密度,功率密度,脈沖,治療時機,治療次數(shù)等。本論文基于第二個問題,以低能量近紅外光(810nm半導(dǎo)體激光)在眼底病治療的參數(shù)為主要的研究對象,在理解低能量激光各參數(shù)的基礎(chǔ)上,對不同能量近紅外光照射青紫藍(lán)兔視網(wǎng)膜后所得實際能量的數(shù)據(jù)分析及視網(wǎng)膜各層細(xì)胞形態(tài)結(jié)構(gòu)的觀察研究,獲得對視網(wǎng)膜相對安全的治療參數(shù);并設(shè)計動物近紅外光LED眼治療儀模型;從而為近紅外光在臨床眼底病治療中提供理論數(shù)據(jù),使其更安全地運用于臨床治療中。實驗內(nèi)容主要如下:1.摘取青紫藍(lán)兔眼球,去除視神經(jīng)正下方鞏膜,置于透明容器中,用810nm激光垂直入射,測量不同能量激光經(jīng)角膜到達(dá)視網(wǎng)膜的實際能量,得出810nm激光在眼球的衰減率;2.對健康青紫藍(lán)兔行不同能量梯度(50mw,100mw,200mw)的810nm激光,3mm光斑照射視網(wǎng)膜,找出光凝閾值,照射后1周后行視網(wǎng)膜組織石蠟切片,觀察不同能量近紅外光對視網(wǎng)膜各層結(jié)構(gòu)的影響。3.設(shè)計近紅外光LED陣列用于動物實驗。通過實驗得出以下結(jié)果:1.810nm激光在眼內(nèi)的衰減率為28-30%左右。2.810nm激光,50mw,3mm光斑,長脈沖模式10min照射對青紫藍(lán)兔視網(wǎng)膜各層結(jié)構(gòu)無損傷,為低能量近紅外光治療眼底病的安全參數(shù)。3.設(shè)計并制作出簡易動物用近紅外光LED陣列。
[Abstract]:Photobiomodulation (Photobiomodulation, PBM) (also known as low level or low energy laser (or light) treatment (low-level laser or light) therapy, LLLT), this year is found that low energy light light biomodulation of fiftieth years, due to the low energy phototherapy biomodulation is very extensive, and there is not invasive advantages, it is widely used in clinical studies, including relieving pain, accelerate wound healing, nerve repair and regeneration of tissue, increase blood flow, improve the treatment of anxiety and depression, Parkinson, retinal diseases. However in many research process, PBM is still a controversial giant. There are two main problems a PBM mechanism is not completely understood, two, in the different treatment of specific parameters is not uniform, such as wavelength, energy density, power density, pulse frequency, treatment time, treatment etc. this thesis is based on second issues, with low Near infrared energy (810nm laser) in the parameters of ocular fundus diseases as the main object of study, based on the understanding of the low energy laser parameters on the observation of different energy near infrared light pigmented retina after the actual energy data analysis and the retinal cell morphology, treatment parameters are relatively safe for the retina; and design animal near infrared LED eye treatment instrument model; near infrared light so as to provide theoretical data in clinical treatment of fundus diseases, make it more safe for clinical treatment. The main contents are as follows: 1. the removal of pigmented eye, remove the optic nerve below the sclera, placed in a transparent container, with 810nm the laser vertical incidence, the actual energy measurement of different laser energy through the cornea to the retina, the decay rate of 810nm laser in eye; 2. of healthy rabbits do not The same energy gradient (50MW, 100MW, 200MW) 810nm laser, 3mm laser spot retinal photocoagulation, find out the threshold, after 1 weeks of retinal tissue paraffin sections after irradiation at different energy near-infrared light effects on retinal layers structure of the.3. design of near infrared LED array used in animal experiments. The following experimental results were obtained: 1.810nm laser in the eye of the decay rate is about 28-30%.2.810nm laser, 50MW, 3mm spot, long pulse mode 10min irradiation damage to the pigmented retina structure, safety parameters of.3. design for low energy near-infrared fundus disease treated by near infrared light and produce LED array with a simple animal.

【學(xué)位授予單位】：電子科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R773;R454.2

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