本文選題：生物彈性體　切入點：檸檬酸　出處：《東華大學(xué)》2017年碩士論文

【摘要】：網(wǎng)絡(luò)型聚酯生物彈性體,作為一類新型的生物醫(yī)用材料,自身具有穩(wěn)定的結(jié)構(gòu)、優(yōu)良的柔韌性、還有與人體軟組織相匹配的模量等優(yōu)點,目前已成為研究者關(guān)注的熱點領(lǐng)域之一。而基于檸檬酸和二醇類化合物聚合形成的網(wǎng)絡(luò)形聚檸檬酸酯類彈性體,由于其在組織工程支架材料和藥物控制釋放材料方面表現(xiàn)出良好應(yīng)用前景,逐漸成為生物彈性體領(lǐng)域研究的熱點之一。本文選擇聚己內(nèi)酯二醇為二醇單體,通過其與檸檬酸熔融縮聚得到聚(己內(nèi)酯二醇-檸檬酸)(PCC)預(yù)聚體,進行熱固化處理得到PCC生物彈性體;再通過將PCC彈性體與甲殼素納米晶須復(fù)合,以改善彈性體的各方面性能;并利用鹽析法制備彈性體多孔支架,以期用于組織工程領(lǐng)域。主要研究工作如下:1、通過熔融縮聚的方法制備PCC生物彈性體,并分別對反應(yīng)投料比、后聚合的溫度和時間進行探索。通過FT-IR、GPC、1H-NMR、DMA、DSC、TGA等測試方法分別對所制得的PCC彈性體的結(jié)構(gòu)和性能進行表征,得出下列結(jié)論:檸檬酸和聚己內(nèi)酯二醇發(fā)生了縮聚反應(yīng);通過調(diào)節(jié)單體摩爾比、后聚合的溫度和時間,可以調(diào)節(jié)材料的力學(xué)性能、親水性能和降解性能等;單體摩爾比為1:1時,在120℃、熱固化7天得到的PCC彈性體綜合性能最佳;材料具有pH響應(yīng)性能,作為藥物控釋材料具有潛在的應(yīng)用性。2、通過將PCC彈性體與甲殼素納米晶須(CW)復(fù)合,以改善PCC彈性體的力學(xué)性能。采用FT-IR、DMA、TGA、XRD等方法對所制得的CW/PCC納米復(fù)合彈性體結(jié)構(gòu)和性能進行表征,得出以下結(jié)論:以丙酮為溶劑,PCC預(yù)聚體與CW能實現(xiàn)均勻混合,固化后可得到CW均勻分散于PCC中的納米復(fù)合物;CW的引入,提高了PCC彈性體的親水性,降低了其溶脹度以及降解速率,同時,明顯增強了納米復(fù)合物的拉伸強度和楊氏模量;此外,CW的引入還改善了PCC彈性體的細胞毒性。3、通過鹽析法制備了PCC以及CW/PCC彈性體多孔支架,并進行了結(jié)構(gòu)與性能表征,得出以下結(jié)論:當致孔劑NaCl的尺寸為400目、預(yù)聚體與致孔劑的質(zhì)量比為1:6時,可以得到性能最佳的PCC彈性體多孔支架;基于PCC彈性體多孔支架的制備條件,制得的CW/PCC多孔支架具有良好的壓縮回復(fù)性,隨著CW含量的增加,多孔支架的力學(xué)性能也不斷增大,最大的壓縮強度達到345kPa;孔隙率在80%左右,吸水率約為105%,CW含量對多孔支架的吸水率及孔隙率影響不大。
[Abstract]:As a new type of biomedical material, the network-type polyester bio-elastomer has the advantages of stable structure, excellent flexibility, and modulus matching with human soft tissue, etc.At present, it has become one of the hot areas that researchers pay attention to.Based on the polymerization of citric acid and diol compounds, the netted polycitrate elastomer has a good application prospect in tissue engineering scaffold materials and drug controlled release materials.It has gradually become one of the hotspots in the field of biological elastomer.In this paper, polycaprolactone was chosen as the monomer of diol, and the prepolymer (caprolactone / citrate) was obtained by melt Polycondensation with citric acid, and the PCC bioelastomer was obtained by thermal curing.Then the PCC elastomer and chitin nano-whisker were combined to improve the properties of the elastomer and the porous scaffold was prepared by salting out method in order to be used in the field of tissue engineering.The main research work is as follows: 1. The PCC bioelastomer was prepared by melt Polycondensation, and the reaction material ratio, the temperature and time of post-polymerization were explored respectively.The structure and properties of the prepared PCC elastomer were characterized by FT-IR GPC-1H-NMR-DMA-DSC-TGA. The following conclusions were obtained: the condensation of citric acid and polycaprolactone, the temperature and time of post-polymerization by adjusting the molar ratio of monomers,The mechanical properties, hydrophilicity and degradability of the PCC elastomer can be adjusted, and the comprehensive properties of the PCC elastomer obtained at 120 鈩，

本文編號：1712618