本文選題：冷熱交替　切入點(diǎn)：模糊控制器　出處：《上海交通大學(xué)》2012年碩士論文　論文類型：學(xué)位論文

【摘要】：腫瘤的熱物理療法在腫瘤治療中已經(jīng)有了相當(dāng)長的歷史。然而,過去三十年中的許多研究表明:相對于單獨(dú)的冷療或者熱療,冷熱交替療法能夠顯著提高對腫瘤組織的殺傷效果。此外,冷熱交替治療還具有其他優(yōu)點(diǎn),如:高溫的治療探針能夠有效的抑制冷療創(chuàng)口的失血;冷熱交替治療可以有效地減少熱療時(shí)被血液帶走的熱量;低溫氣體也可以防止熱療時(shí)針尖過熱;同時(shí),冷熱交替療法能夠激發(fā)抗腫瘤免疫響應(yīng),從而抑制腫瘤轉(zhuǎn)移和復(fù)發(fā)。 本實(shí)驗(yàn)室自主研發(fā)了一種新型冷熱交替治療儀,采用液氮制冷和射頻加熱,可單獨(dú)進(jìn)行液氮冷凍的低溫手術(shù)和射頻熱療,也可將兩者有機(jī)的結(jié)合,根據(jù)需要靈活使用。但是由于冷、熱療的集成,提高了儀器控制方面的困難程度,且沒有成熟的理論及經(jīng)驗(yàn)可以供參考,系統(tǒng)在控制方面還不完善,不能完全滿足臨床應(yīng)用的要求,故只有設(shè)計(jì)出一套安全可靠的控制算法,才能使冷熱療技術(shù)真正造福于腫瘤患者。 本研究基于此治療儀,為液氮冷療和射頻熱療設(shè)計(jì)了模糊控制器和模糊邏輯PID控制器,使直徑在10mm到30mm之間的靶組織的邊緣溫度可以在3分鐘內(nèi)到達(dá)目標(biāo)溫度,并且冷、熱療溫度的穩(wěn)態(tài)誤差分別達(dá)到了2℃和1℃以內(nèi),實(shí)現(xiàn)了溫度的快速響應(yīng)和精確控制。同時(shí),創(chuàng)新性地將氣液兩相氮用于射頻熱療時(shí)的探針冷卻,提高了射頻熱療的穩(wěn)定性,增大了消融范圍。最后,所設(shè)計(jì)的控制方法的控制效果在離體豬肝實(shí)驗(yàn)、兔子和老鼠的在體腫瘤實(shí)驗(yàn)中得到了驗(yàn)證。
[Abstract]:Tumor thermophysiotherapy has a long history in tumor therapy. However, many studies over the past three decades have shown that, compared to cold or hyperthermia alone, Alternative therapy of cold and heat can significantly improve the killing effect on tumor tissue. In addition, the alternative therapy of cold and heat has other advantages, such as: the hyperthermia probe can effectively inhibit the blood loss in the wound of cold therapy; Alternative therapy of cold and heat can effectively reduce the heat taken away by the blood during hyperthermia; low temperature gas can also prevent the tip from overheating during hyperthermia; at the same time, alternative therapy of cold and heat can stimulate the anti-tumor immune response and thus inhibit tumor metastasis and recurrence. Our laboratory has developed a new type of alternately cold and hot therapeutic instrument, which can be used to refrigerate liquid nitrogen and radiofrequency heating, to perform cryogenic surgery and radiofrequency hyperthermia alone, or to combine them organically. According to the need for flexible use. But because of the integration of cold and hyperthermia, the difficulty of instrument control is increased, and there is no mature theory and experience for reference, the system is not perfect in control, Only by designing a set of safe and reliable control algorithm can the cold and hyperthermia technology benefit tumor patients. Based on this therapeutic instrument, a fuzzy controller and a fuzzy logic PID controller are designed for liquid nitrogen cooling therapy and radiofrequency hyperthermia. The temperature of the edge of the target tissue between 10 mm and 30 mm in diameter can reach the target temperature and be cold in 3 minutes. The steady-state error of the hyperthermia temperature is within 2 鈩，

本文編號：1643822