本文關(guān)鍵詞： 人工氣管 氣管重建 聚四氟乙烯 上皮化 兔　出處：《中國修復(fù)重建外科雜志》2014年07期 　論文類型：期刊論文

【摘要】：目的觀察聚四氟乙烯人工氣管體內(nèi)植入后的形態(tài)學(xué)及病理學(xué)變化。方法取聚四氟乙烯微孔管,其外包繞聚丙烯螺旋絲,預(yù)制成人工氣管。取新西蘭白兔40只,體重4~5 kg,切除頸段氣管2 cm,制備氣管缺損動物模型。實(shí)驗(yàn)組(n=20)用人工氣管與氣管上、下端端吻合;正常對照組(n=20)行一期氣管端端吻合術(shù)。術(shù)后觀察動物存活情況,并于術(shù)后2、4、6個月行X線片觀察,取材行大體觀察、組織學(xué)觀察;對移植前后人工氣管行縱向拉伸及徑向支撐生物力學(xué)試驗(yàn),并與正常對照組比較。結(jié)果實(shí)驗(yàn)組15只動物存活超過2個月并保持人工氣管通暢;術(shù)后4個月以后人工氣管外組織生成類似氣管樣組織,可填充缺損區(qū)域;同期正常對照組動物全部存活。術(shù)后各時間點(diǎn)X線片示實(shí)驗(yàn)組人工氣管均無明顯移位,位置保持良好;正常對照組均未見氣管狹窄。組織學(xué)觀察示,實(shí)驗(yàn)組術(shù)后2個月人工氣管內(nèi)壁無明顯上皮組織;4個月人工氣管內(nèi)壁有部分上皮細(xì)胞覆蓋,未完全內(nèi)皮化,未見氣管纖毛柱狀上皮,氣管各層次不完整;6個月人工氣管內(nèi)壁基本被上皮細(xì)胞覆蓋,并出現(xiàn)部分氣管纖毛柱狀上皮,基本具備了氣管的生理功能。生物力學(xué)試驗(yàn)結(jié)果示,聚四氟乙烯人工氣管移植后可保持穩(wěn)定的生物力學(xué)性能,適用于兔氣管重建。結(jié)論聚四氟乙烯人工氣管可誘導(dǎo)受體氣管內(nèi)外組織生成氣管樣組織,氣管各層次較符合生理學(xué)狀態(tài),實(shí)驗(yàn)動物可短期存活。
[Abstract]:Objective to observe the morphological and pathological changes of polytetrafluoroethylene (PTFE) artificial trachea implanted in vivo. The animal model of trachea defect was established by resecting the cervical trachea for 2 cm. The experimental group was treated with artificial trachea anastomosis with the upper and lower end of trachea and the normal control group with one-stage trachea end-to-end anastomosis. The survival of the animals was observed after operation. X ray films, gross observation and histological observation were performed at 2 and 6 months after transplantation, and longitudinal stretching and radial support biomechanical tests were performed on the artificial trachea before and after transplantation. Results 15 animals in the experimental group survived for more than 2 months and kept the artificial trachea unobstructed. At the same time, all the animals in the normal control group survived. X-ray films showed that the artificial trachea in the experimental group was not obviously displaced and the position was maintained well, and no trachea stenosis was found in the normal control group. In the experimental group, there was no obvious epithelium in the inner wall of the artificial trachea 2 months after operation, and there were some epithelial cells in the inner wall of the artificial trachea for 4 months, and no columnar epithelium of tracheal cilia. The inner wall of the artificial trachea was basically covered by epithelial cells, and some of the cilia columnar epithelium appeared in the trachea for 6 months, which basically possessed the physiological function of the trachea. Polytetrafluoroethylene (PTFE) artificial trachea can maintain stable biomechanical properties and be suitable for trachea reconstruction in rabbits. Conclusion PTFE artificial trachea can induce trachea-like tissue to form in and out of the recipient trachea. All levels of trachea were in a physiological state, and experimental animals could survive for a short time.
【作者單位】： 西安交通大學(xué)第一附屬醫(yī)院胸外二科;西安交通大學(xué)第二附屬醫(yī)院腫瘤外科;西安交通大學(xué)第一附屬醫(yī)院病理科;西安交通大學(xué)第一附屬醫(yī)院手術(shù)部;
【分類號】：R318.13

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