慢性自發(fā)性蕁麻疹與部分生化指標的相關性分析
發(fā)布時間：2019-03-31 18:01
【摘要】：目的1、分析慢性自發(fā)性蕁麻疹患者的病情特點;2、探討慢性自發(fā)性蕁麻疹的發(fā)生與部分生化指標的聯(lián)系;3、探討部分生化指標對慢性自發(fā)性蕁麻疹嚴重程度的影響。方法收集2015年4月至2016年8月于首都醫(yī)科大學宣武醫(yī)院皮膚性病科就診的慢性自發(fā)性蕁麻疹患者,記錄患者的一般情況、對每位患者進行UAS評分及BMI測算,抽取患者空腹狀態(tài)下外周靜脈血進行生化指標檢測,包括尿酸(uric acid,UA)、血糖(serum glucose,GLU)、甘油三酯(triglyceride,TG)、總膽固醇(total cholesterol,TCH)、低密度脂蛋白(low density lipoprotein,LDL-C),同時對每位患者進行血清總IgE檢測。同期收集于首都醫(yī)科大學宣武醫(yī)院進行健康體檢者作為對照組,收集其相關生化檢測結果。用Microsoft Excel 2007對數據進行整理,用SPSS 22.0處理并分析數據。結果1、72例慢性自發(fā)性蕁麻疹患者中,男性24例,女性48例,平均年齡(43.5±13.0)歲。33例對照組中,男性17例,女性16例,平均年齡(46.8±18.0)歲。兩組的年齡、性別均無統(tǒng)計學差異(p0.05)。2、72例慢性自發(fā)性蕁麻疹患者中,27.8%的患者風團發(fā)作頻率為每天多次,50%的患者風團發(fā)作頻率為每天一次,22.2%的患者風團發(fā)作頻率為多天一次。3、72例慢性自發(fā)性蕁麻疹患者中,33.3%的患者風團持續(xù)時間小于1h,31.9%的患者風團持續(xù)時間為1-4h,8.3%的患者風團持續(xù)時間為4-8h,9.7%的患者風團持續(xù)時間為8-16h,13.8%的患者風團持續(xù)時間為16-24h,2.8%的患者風團持續(xù)時間大于24h。4、72例慢性自發(fā)性蕁麻疹患者中,2.8%的患者UAS評分為2分,15.3%的患者UAS評分為3分,26.4%的患者UAS評分為4分,31.9%的患者UAS評分為5分,23.6%的患者UAS評分為6分。5、72例慢性自發(fā)性蕁麻疹患者中,2.8%的患者體重指數小于18.5,50%的患者體重指數在18.5-23.9之間,34.7%的患者體重指數在24.0-27.9之間,12.5%的患者體重指數大于28.0。6、72例慢性自發(fā)性蕁麻疹患者與33例健康對照者相比,患者組TG升高率(23.6%)明顯高于對照組(6.1%),其差異具有統(tǒng)計學意義(p=0.030),患者組與對照組的UA升高率、GLU升高率、TCH升高率、LDL-C升高率均無統(tǒng)計學差異(p0.05)。7、13例UAS評分1-3分者與59例UAS評分4-6分者相比,UA升高率、GLU升高率、TG升高率、TCH升高率、LDL-C升高率均無統(tǒng)計學差異(p0.05)。8、13例UAS評分1-3分者與59例UAS評分4-6分者相比,BMI異常率無統(tǒng)計學差異(p=1)。9、13例UAS評分1-3分者與59例UAS評分4-6分者相比,血清總IgE升高率具有統(tǒng)計學差異(p=0.048)。結論1、慢性自發(fā)性蕁麻疹的發(fā)生可能受到甘油三酯升高的影響;2、慢性蕁麻疹嚴重程度可能與血清總IgE呈正相關。
[Abstract]:Objective 1. To analyze the characteristics of patients with chronic spontaneous urticaria, (2) to explore the relationship between the occurrence of chronic spontaneous urticaria and some biochemical indexes, and (3) to explore the influence of some biochemical indexes on the severity of chronic spontaneous urticaria. Methods from April 2015 to August 2016, the patients with chronic spontaneous urticaria were collected from the Department of Dermatology, Xuanwu Hospital, Capital Medical University. The general situation of the patients was recorded, and the UAS score and BMI of each patient were calculated. Peripheral venous blood samples were taken from the patients on an empty stomach for biochemical examination, including uric acid (uric acid,UA), blood glucose (serum glucose,GLU), triglyceride (triglyceride,TG), total cholesterol (total cholesterol,TCH), low density lipoprotein (low density lipoprotein, (LDL (low density lipoprotein,). At the same time, the serum total IgE of each patient was detected by LDL-C. At the same time, the healthy physical examiners were collected from Xuanwu Hospital of Capital Medical University as the control group, and the results of biochemical tests were collected. Microsoft Excel 2007 was used to organize the data, and SPSS 22.0 was used to process and analyze the data. Results 1. Among the 72 patients with chronic spontaneous urticaria, there were 24 males and 48 females with an average age of (43.5 鹵13.0) years. In the control group, there were 17 males and 16 females with an average age of (46.8 鹵18.0) years. There was no significant difference in age and sex between the two groups (p0.05). 2. In 72 patients with chronic spontaneous urticaria, 27.8% of the patients had multiple episodes of wind mass a day, and 50% of the patients had a frequency of wind mass attack once a day, and there was no significant difference in age and sex between the two groups (p0.05). 22.2% of the patients had a multiple-day attack frequency. 3. Of 72 patients with chronic spontaneous urticaria, 33.3% had a wind mass duration of less than 1 hour, and 31.9% of the patients had a wind mass duration of 1-4 hours. 8.3% of the patients had a duration of 4-8 hours, 9.7% had a duration of 8-16 hours, and 13.8% had a duration of 16-24 hours, while 8.3% had a duration of 4-8 h, 9.7% had a duration of 8-16 h and 13.8% had a duration of 16-24 h. Of the 72 patients with chronic spontaneous urticaria, 2.8% had a UAS score of 2, 15.3% had a UAS score of 3, and 26.4% had a UAS score of 4. Among 72 patients with chronic spontaneous urticaria, 2.8% had body mass index (BMI) less than 18.5 and 50% had BMI between 18.5 and 23.9, respectively. The UAS score was 5 in 31.9% of the patients, and 23.5% in 23.6% of the patients with chronic spontaneous urticaria. The body mass index (BMI) of 34.7% of the patients was between 24.0 and 27.9, 12.5% of the patients was more than 28.0.6%, and 72 of the patients with chronic spontaneous urticaria were compared with 33 healthy controls. The increase rate of TG in the patient group (23.6%) was significantly higher than that in the control group (6.1%), and the difference was statistically significant (p < 0.030). The increase rate of UA, GLU and TCH in the patient group and the control group was significantly higher than that in the control group (P < 0.05). There was no statistical difference in LDL-C elevation rate (p0.05). 13 cases with UAS score of 1-3 were compared with 59 cases with UAS score of 4-6 points, UA rising rate, GLU rising rate, TG rising rate and TCH rising rate were higher than those of 59 cases with UAS score of 4 and 6 points, and there was no statistical difference between them (p0.05). There was no significant difference in LDL-C elevation rate (p0.05). 13 cases with UAS score of 1-3 were compared with 59 cases with UAS score of 4-6 points. There was no significant difference in the abnormal rate of BMI between the 13 cases with UAS score of 1-3 and the 59 cases with UAS score of 4 and 6, and the increase rate of total IgE in serum was statistically different (p < 0. 048) compared with that of 59 cases with UAS score of 4-3 points (p < 0. 048). Conclusion 1. The occurrence of chronic spontaneous urticaria may be affected by the increase of triglyceride, and the severity of chronic urticaria may be positively correlated with serum total IgE.
【學位授予單位】：首都醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R758.24
本文編號：2451148
[Abstract]:Objective 1. To analyze the characteristics of patients with chronic spontaneous urticaria, (2) to explore the relationship between the occurrence of chronic spontaneous urticaria and some biochemical indexes, and (3) to explore the influence of some biochemical indexes on the severity of chronic spontaneous urticaria. Methods from April 2015 to August 2016, the patients with chronic spontaneous urticaria were collected from the Department of Dermatology, Xuanwu Hospital, Capital Medical University. The general situation of the patients was recorded, and the UAS score and BMI of each patient were calculated. Peripheral venous blood samples were taken from the patients on an empty stomach for biochemical examination, including uric acid (uric acid,UA), blood glucose (serum glucose,GLU), triglyceride (triglyceride,TG), total cholesterol (total cholesterol,TCH), low density lipoprotein (low density lipoprotein, (LDL (low density lipoprotein,). At the same time, the serum total IgE of each patient was detected by LDL-C. At the same time, the healthy physical examiners were collected from Xuanwu Hospital of Capital Medical University as the control group, and the results of biochemical tests were collected. Microsoft Excel 2007 was used to organize the data, and SPSS 22.0 was used to process and analyze the data. Results 1. Among the 72 patients with chronic spontaneous urticaria, there were 24 males and 48 females with an average age of (43.5 鹵13.0) years. In the control group, there were 17 males and 16 females with an average age of (46.8 鹵18.0) years. There was no significant difference in age and sex between the two groups (p0.05). 2. In 72 patients with chronic spontaneous urticaria, 27.8% of the patients had multiple episodes of wind mass a day, and 50% of the patients had a frequency of wind mass attack once a day, and there was no significant difference in age and sex between the two groups (p0.05). 22.2% of the patients had a multiple-day attack frequency. 3. Of 72 patients with chronic spontaneous urticaria, 33.3% had a wind mass duration of less than 1 hour, and 31.9% of the patients had a wind mass duration of 1-4 hours. 8.3% of the patients had a duration of 4-8 hours, 9.7% had a duration of 8-16 hours, and 13.8% had a duration of 16-24 hours, while 8.3% had a duration of 4-8 h, 9.7% had a duration of 8-16 h and 13.8% had a duration of 16-24 h. Of the 72 patients with chronic spontaneous urticaria, 2.8% had a UAS score of 2, 15.3% had a UAS score of 3, and 26.4% had a UAS score of 4. Among 72 patients with chronic spontaneous urticaria, 2.8% had body mass index (BMI) less than 18.5 and 50% had BMI between 18.5 and 23.9, respectively. The UAS score was 5 in 31.9% of the patients, and 23.5% in 23.6% of the patients with chronic spontaneous urticaria. The body mass index (BMI) of 34.7% of the patients was between 24.0 and 27.9, 12.5% of the patients was more than 28.0.6%, and 72 of the patients with chronic spontaneous urticaria were compared with 33 healthy controls. The increase rate of TG in the patient group (23.6%) was significantly higher than that in the control group (6.1%), and the difference was statistically significant (p < 0.030). The increase rate of UA, GLU and TCH in the patient group and the control group was significantly higher than that in the control group (P < 0.05). There was no statistical difference in LDL-C elevation rate (p0.05). 13 cases with UAS score of 1-3 were compared with 59 cases with UAS score of 4-6 points, UA rising rate, GLU rising rate, TG rising rate and TCH rising rate were higher than those of 59 cases with UAS score of 4 and 6 points, and there was no statistical difference between them (p0.05). There was no significant difference in LDL-C elevation rate (p0.05). 13 cases with UAS score of 1-3 were compared with 59 cases with UAS score of 4-6 points. There was no significant difference in the abnormal rate of BMI between the 13 cases with UAS score of 1-3 and the 59 cases with UAS score of 4 and 6, and the increase rate of total IgE in serum was statistically different (p < 0. 048) compared with that of 59 cases with UAS score of 4-3 points (p < 0. 048). Conclusion 1. The occurrence of chronic spontaneous urticaria may be affected by the increase of triglyceride, and the severity of chronic urticaria may be positively correlated with serum total IgE.
【學位授予單位】：首都醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R758.24
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