1030例漢族兒童異位性皮炎患者臨床特征與總IgE相關(guān)性研究
發(fā)布時(shí)間：2019-03-31 00:56
【摘要】：背景異位性皮炎(atopic dermatitis,AD)是一種慢性、炎癥性、反復(fù)發(fā)作性疾病,好發(fā)于嬰兒和兒童,常常伴有血清總IgE(tIgE)升高。關(guān)于tIgE水平與AD臨床特征在中國漢族中的研究不多,本研究對(duì)1030例AD兒童血清tIgE與臨床特征進(jìn)行回顧性分析。 目的探討兒童異位性皮炎(AD) tIgE與臨床特征的相互關(guān)系。 方法采用調(diào)查表的形式收集2008年1月至2010年3月來自全國多家醫(yī)院的1030例兒童AD患者,均符合Hanifin-Rajka診斷標(biāo)準(zhǔn)。所有患者均采用AllergyScreen過敏原定量檢測系統(tǒng)檢測血清tIgE,并采用統(tǒng)一的問卷調(diào)查對(duì)病人及家屬進(jìn)行臨床流行病學(xué)調(diào)查。應(yīng)用Epi info 6.0軟件、SPSS10.0軟件對(duì)資料進(jìn)行統(tǒng)計(jì)學(xué)處理和分析,采用單樣本Kolmogorov - Smirnov檢驗(yàn),卡方檢驗(yàn)和非參數(shù)檢驗(yàn),探討tIgE值與AD臨床特征的相關(guān)性。 結(jié)果1030例患兒中,男性為634例,女性為396例,男女比例為1.6:1。病人的平均年齡為1.5(0.5,5)歲,平均發(fā)病年齡為2(1,4)月,平均病程為3(2,7)月。患者的當(dāng)前年齡范圍是36天～12歲,發(fā)病年齡的范圍是2天～11歲。1030例AD患兒中,499(48.4%)例患兒伴有血清tIgE水平升高,928(90.1%)例為城市兒童。與tIgE水平正常的患兒相比,tIgE水平升高的患兒發(fā)病年齡大(P 0.001)。tIgE升高組的“混合型”AD的患病率明顯高于正常組(P 0.001),伴有tIgE升高的患兒更易伴發(fā)哮喘(BA()P 0.001)和過敏性皮炎(AR)(P = 0.036),但兩組在家族異位性病上差異無顯著性(P 0.05)。根據(jù)Mann-Whitney檢驗(yàn),tIgE升高組的SCORAD評(píng)分和OSAAD評(píng)分明顯高于正常組(P 0.001和P = 0.001);根據(jù)秩和檢驗(yàn),兩組AD的嚴(yán)重程度差異有顯著性(P 0.001),伴有tIgE升高的患兒重度AD的可能性更大。在Hanifin-Rajka診斷標(biāo)準(zhǔn)的23項(xiàng)次要體征中早期發(fā)病年齡(90.9%)、干燥(74.8%)和面部蒼白/紅斑(70.5%)最常見。對(duì)除了tIgE升高外其他的次要體征進(jìn)行統(tǒng)計(jì)學(xué)分析,部分在tIgE升高組和tIgE正常組中差異有顯著性(均P 0.05)。 結(jié)論通過tIgE與兒童AD臨床特征之間的相關(guān)性分析,得出tIgE可能是導(dǎo)致兒童AD嚴(yán)重度及臨床特征有差異的原因之一,從而進(jìn)一步對(duì)疾病的診斷、治療和預(yù)后提供線索。
[Abstract]:Background atopic dermatitis (atopic dermatitis,AD) is a chronic inflammatory recurrent paroxysmal disease that occurs in infants and children and is often associated with elevated serum total IgE (tIgE). There are few studies on the clinical characteristics of tIgE and AD in Chinese Han nationality. The serum tIgE and clinical characteristics of 1030 children with AD were retrospectively analyzed in this study. Objective to investigate the relationship between (AD) tIgE and clinical features in children with atopic dermatitis. Methods from January 2008 to March 2010, 1030 cases of children with AD from many hospitals in China were collected by questionnaire. All of them met the diagnostic criteria of Hanifin-Rajka. Serum tIgE, was detected by AllergyScreen allergen quantitative detection system in all patients and clinical epidemiological investigation of patients and their families was carried out by unified questionnaire survey. The data were statistically processed and analyzed by Epi info 6.0software and SPSS10.0 software. Single sample Kolmogorov-Smirnov test, chi-square test and nonparametric test were used to explore the correlation between tIgE value and clinical features of AD. Results of the 1030 children, 634 were male and 396 were female. The ratio of male to female was 1.6%. The mean age of the patients was 1.5 (0.5, 5) years old. The mean age of onset was 2 (1, 4) months, and the mean course of disease was 3 (2, 7) months. The current age range of the patients ranged from 36 days to 12 years, and the age of onset ranged from 2 days to 11 years. Of the 1030 children with AD, 499 (48.4%) were accompanied by elevated serum tIgE levels, and 928 (90.1%) were urban children. Compared with the children with normal tIgE level, the children with elevated tIgE level had older onset age (P 0.001). The prevalence of "mixed" AD in the group with elevated tige level was significantly higher than that in the normal group (P 0.001). Children with elevated tIgE were more likely to have asthma (BA () P 0.001 (P 0.05) and allergic dermatitis (AR) (P = 0.036), but there was no significant difference in family ectopic venereal disease between the two groups (P 0.05). According to the Mann-Whitney test, the SCORAD score and OSAAD score in the tIgE elevation group were significantly higher than those in the normal group (P 0.001 and P = 0.001). According to the rank sum test, there was a significant difference in the severity of AD between the two groups (P 0.001). The children with elevated tIgE were more likely to have severe AD. The early onset age (90.9%), dry (74.8%) and pale / erythema (70.5%) were the most common of the 23 secondary signs of Hanifin-Rajka. In addition to the increase of tIgE, other secondary signs were statistically analyzed, and some of them were significantly different between the tIgE elevated group and the normal tIgE group (all P 0.05). Conclusion by analyzing the correlation between tIgE and clinical features of children with AD, it can be concluded that tIgE may be one of the reasons for the difference of severity and clinical features of AD in children, so as to provide clues for the diagnosis, treatment and prognosis of the disease.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R758.29
本文編號(hào)：2450672
[Abstract]:Background atopic dermatitis (atopic dermatitis,AD) is a chronic inflammatory recurrent paroxysmal disease that occurs in infants and children and is often associated with elevated serum total IgE (tIgE). There are few studies on the clinical characteristics of tIgE and AD in Chinese Han nationality. The serum tIgE and clinical characteristics of 1030 children with AD were retrospectively analyzed in this study. Objective to investigate the relationship between (AD) tIgE and clinical features in children with atopic dermatitis. Methods from January 2008 to March 2010, 1030 cases of children with AD from many hospitals in China were collected by questionnaire. All of them met the diagnostic criteria of Hanifin-Rajka. Serum tIgE, was detected by AllergyScreen allergen quantitative detection system in all patients and clinical epidemiological investigation of patients and their families was carried out by unified questionnaire survey. The data were statistically processed and analyzed by Epi info 6.0software and SPSS10.0 software. Single sample Kolmogorov-Smirnov test, chi-square test and nonparametric test were used to explore the correlation between tIgE value and clinical features of AD. Results of the 1030 children, 634 were male and 396 were female. The ratio of male to female was 1.6%. The mean age of the patients was 1.5 (0.5, 5) years old. The mean age of onset was 2 (1, 4) months, and the mean course of disease was 3 (2, 7) months. The current age range of the patients ranged from 36 days to 12 years, and the age of onset ranged from 2 days to 11 years. Of the 1030 children with AD, 499 (48.4%) were accompanied by elevated serum tIgE levels, and 928 (90.1%) were urban children. Compared with the children with normal tIgE level, the children with elevated tIgE level had older onset age (P 0.001). The prevalence of "mixed" AD in the group with elevated tige level was significantly higher than that in the normal group (P 0.001). Children with elevated tIgE were more likely to have asthma (BA () P 0.001 (P 0.05) and allergic dermatitis (AR) (P = 0.036), but there was no significant difference in family ectopic venereal disease between the two groups (P 0.05). According to the Mann-Whitney test, the SCORAD score and OSAAD score in the tIgE elevation group were significantly higher than those in the normal group (P 0.001 and P = 0.001). According to the rank sum test, there was a significant difference in the severity of AD between the two groups (P 0.001). The children with elevated tIgE were more likely to have severe AD. The early onset age (90.9%), dry (74.8%) and pale / erythema (70.5%) were the most common of the 23 secondary signs of Hanifin-Rajka. In addition to the increase of tIgE, other secondary signs were statistically analyzed, and some of them were significantly different between the tIgE elevated group and the normal tIgE group (all P 0.05). Conclusion by analyzing the correlation between tIgE and clinical features of children with AD, it can be concluded that tIgE may be one of the reasons for the difference of severity and clinical features of AD in children, so as to provide clues for the diagnosis, treatment and prognosis of the disease.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R758.29
【引證文獻(xiàn)】
相關(guān)期刊論文 前1條
1 張秀欽;程波;肖鵬;王菁;;某地區(qū)特應(yīng)性皮炎患者過敏原檢測分析[J];中國醫(yī)藥指南;2012年28期
，本文編號(hào)：2450672
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