【摘要】：目的:探討獲得性反應(yīng)性穿通性膠原病(ARPC)的臨床表現(xiàn)、發(fā)病機(jī)制和組織病理特點(diǎn)。方法:回顧性分析7例ARPC患者的臨床資料,同時(shí)復(fù)習(xí)國內(nèi)外文獻(xiàn)。結(jié)果:7例患者中男5例,女2例,年齡50~67歲。其中3例患者有基礎(chǔ)疾病,4例患者在隨訪中復(fù)發(fā),1例出現(xiàn)腫瘤指標(biāo)異常。7例患者皮損Kobner現(xiàn)象均陽性,且皮損組織病理表現(xiàn)相似。結(jié)論:ARPC臨床表現(xiàn)大多無特異性,需結(jié)合病史和組織病理檢查明確診斷,目前尚無統(tǒng)一的治療方案,減輕瘙癢是治療的關(guān)鍵因素之一,該病的復(fù)發(fā)可能與患者是否存在系統(tǒng)性疾病有關(guān)。
[Abstract]:Objective: to investigate the clinical manifestations, pathogenesis and histopathological features of acquired reactive penetrating collagenosis (ARPC). Methods: the clinical data of 7 patients with ARPC were retrospectively analyzed and the literature at home and abroad were reviewed. Results: there were 5 males and 2 females aged 50 to 67 years. Among them, 3 patients had basic diseases, 4 patients had recurrence during follow-up, 1 patient had abnormal tumor index, 7 patients had positive Kobner phenomenon in skin lesions, and the histopathological manifestations of skin lesions were similar. Conclusion: most of the clinical manifestations of ARPC are nonspecific, so it is necessary to make a definite diagnosis in combination with the history and histopathological examination. There is no unified treatment plan at present. Reducing pruritus is one of the key factors in the treatment. The recurrence of the disease may be related to the existence of systemic disease.
【作者單位】： 上海市皮膚病醫(yī)院中西醫(yī)結(jié)合皮膚科;
【分類號】：R758.6

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