【摘要】：目的探討天皰瘡患者感染狀況及預(yù)防感染的干預(yù)措施。方法選取醫(yī)院2013年1月-2016年12月收治的56例天皰瘡合并感染患者為感染組,選擇同期住院治療的天皰瘡非感染患者60例為對照組,比較兩組患者性別、年齡、病程、感染部位、住院天數(shù)、住院費用、激素用量等臨床資料及痊愈率,感染組患者分別取血、尿、痰和傷口滲液等標(biāo)本,進(jìn)行病原菌鑒定。結(jié)果 56例天皰瘡合并感染患者中感染部位前兩位為皮膚軟組織29例,占51.79%及口腔12例,占21.43%;56例天皰瘡合并感染患者共檢出病原菌64株,革蘭陰性菌35株、革蘭陽性菌27株、真菌2株,分別占54.69%、42.19%和3.13%;檢出前4位的病原菌分別為肺炎克雷伯菌16株,占25.00%、金黃色葡萄球菌12株,占18.75%、表皮葡萄球菌8株,占12.50%和大腸埃希菌7株,占10.94%;感染組患者住院天數(shù)、住院費用和激素用量均顯著高于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P0.05),痊愈率顯著低于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論天皰瘡患者最常見的感染部位為皮膚軟組織及口腔,感染病原菌以革蘭陰性菌為主,繼發(fā)感染可延長天皰瘡住院時間,增加激素使用量和住院費用,預(yù)后較差。
[Abstract]:Objective to investigate the infection status of pemphigus patients and the intervention measures to prevent infection. Methods from January 2013 to December 2016, 56 patients with pemphigus complicated with infection were selected as infection group and 60 patients with pemphigus as control group. The sex, age and course of disease were compared between the two groups. The infection site, hospitalization days, hospitalization expenses, hormone dosage and cure rate were collected from the infected patients. The samples of blood, urine, sputum and wound exudate were collected to identify the pathogenic bacteria in the infected group. Results among 56 cases of pemphigus complicated with infection, 29 cases (51.79%) were skin and soft tissue, 12 cases (21.43%) were oral cavity. There were 64 pathogenic bacteria, 35 Gram-negative bacteria, 27 Gram-positive bacteria and 2 fungi, accounting for 42.19% and 3.13%, respectively, in 56 patients with pemphigus co-infection. The top 4 pathogens were Klebsiella pneumoniae 16 strains (25.00%), Staphylococcus aureus 12 strains (18.75%), Staphylococcus epidermidis 8 strains (12.50%) and Escherichia coli 7 strains (10.94%). The days of hospitalization, hospitalization expenses and hormone dosage in the infection group were significantly higher than those in the control group, the difference between the two groups was statistically significant (P0.05), the cure rate was significantly lower than that in the control group, and the difference between the two groups was statistically significant (P0.05). Conclusion the most common infection sites in pemphigus patients are skin soft tissue and oral cavity. Gram-negative bacteria are the main pathogens of pemphigus infection. Secondary infection can prolong the hospitalization time of pemphigus, increase the use of hormones and hospital expenses, and the prognosis is poor.
【作者單位】： 西南醫(yī)科大學(xué)附屬醫(yī)院皮膚科;
【分類號】：R758.66

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