發(fā)布時間：2018-07-17 01:17

【摘要】：目的銀屑病存在易復發(fā)、難治愈的特點,且采用聯(lián)合用藥治療銀屑病的研究較少。文中旨在研究白芍總苷膠囊(TGP)聯(lián)合阿維A、復方氟米松治療尋常性銀屑病(PV)的臨床效果及對患者外周血細胞因子水平的影響。方法選取2015年10月至2017年1月于蘇州大學附屬第一醫(yī)院皮膚科就診的126例PV患者,隨機數(shù)字表法分為聯(lián)合用藥組(阿維A+復方氟米松軟膏+TGP)和對照組(阿維A+復方氟米松軟膏),每組63例。通過對2組患者治療前后外周血白細胞介素IL-17、IL-18、IL-23等指標水平綜合評價臨床治療效果。結果 2組銀屑病患者治療后IL-17、IL-18及IL-23濃度較治療前均明顯降低,聯(lián)合用藥組3項指標下降幅度最大(P0.05);治療后聯(lián)合用藥組IL-17[(61.18±8.91)pg/m L]、IL-18[(68.56±17.95)pg/m L]及IL-23濃度[(70.13±12.16)pg/m L]均明顯低于對照組[(78.64±7.85)、(79.49±18.64)、(91.18±16.89)pg/m L],差異有統(tǒng)計學意義(P0.05)。治療后聯(lián)合用藥組TNF-α[(14.47±7.53)ng/L]、PASI評分[(4.09±1.29)分]及皮損總面積百分比[(6.17±4.59)%]均明顯低于對照組[(23.49±8.12)ng/L、(7.29±5.13)分、(8.09±5.18)%],且較治療前顯著下降,差異有統(tǒng)計學意義(P0.05)。2組不良反應發(fā)生率比較差異無統(tǒng)計學意義(P0.05)。聯(lián)合用藥組治療總有效率較對照組明顯升高(85.71%vs 65.08%,P0.05)。結論白芍總苷膠囊聯(lián)合阿維A、復方氟米松可有效調節(jié)IL-17、IL-18、IL-23及TNF-α水平,從而顯著提高銀屑病的臨床治療效果。
[Abstract]:Objective Psoriasis is easy to relapse and difficult to cure. The aim of this study was to study the clinical effect of total glucoside of paeony (TGP) combined with Avera and compound flutamethasone in the treatment of psoriasis vulgaris (PV) and the effect of TGP on peripheral blood cytokine levels in patients with psoriasis vulgaris. Methods 126 patients with PV were selected from October 2015 to January 2017 in the Department of Dermatology, the first affiliated Hospital of Suzhou University. The patients were randomly divided into two groups: Avera compound flutamethasone ointment (TGP) and control group (Avera compound flumisone ointment) with 63 cases in each group. The clinical therapeutic effect was evaluated by the level of IL-17, IL-18 and IL-23 in peripheral blood before and after treatment. Results the levels of IL-17, IL-18 and IL-23 in patients with psoriasis after treatment were significantly lower than those before treatment. The levels of IL-17 [(61.18 鹵8.91) pg/m L] and IL-23 [(68.56 鹵17.95) pg/m L] and IL-23 (70.13 鹵12.16 pg/m L) in the combined treatment group were significantly lower than those in the control group [(78.64 鹵7.85), (79.49 鹵18.64), (91.18 鹵16.89) pg/m L] after treatment (P0.05). After treatment, the TNF- 偽 [(14.47 鹵7.53) ng / L] PASI score [(4.09 鹵1.29) scores] and the percentage of total lesion area [(6.17 鹵4.59)%] were significantly lower in the combined group than in the control group [(23.49 鹵8.12) ng / L, (7.29 鹵5.13), (8.09 鹵5.18)%]. The total effective rate of the combined treatment group was significantly higher than that of the control group (85.71%vs 65.08 and P0.05). Conclusion Total glucoside capsule of paeony combined with Avera and compound flumisone can effectively regulate the levels of IL-17, IL-18, IL-23 and TNF- 偽, so as to improve the clinical therapeutic effect of psoriasis.
【作者單位】： 蘇州大學附屬第一醫(yī)院皮膚科;
【分類號】：R758.63

【參考文獻】

相關期刊論文 前10條

1 郝麗英;任芳;寇彩霞;鄧東靈;桑紅;;基于Framingham評分的銀屑病患者心血管風險評估[J];醫(yī)學研究生學報;2017年06期

2 初金玉;劉麗英;鄂佳;楊靜;王晶;;銀屑膠囊聯(lián)合復方氟米松軟膏治療尋常型銀屑病的臨床觀察[J];中國藥房;2016年26期

3 劉盼盼;匡葉紅;張江林;李捷;粟娟;陳翔;朱武;;阿維A與氨甲蝶呤治療重度斑塊型銀屑病的療效[J];中南大學學報(醫(yī)學版);2016年08期

4 陳曦;李玲玲;張潤田;夏夢;董玢;段行武;;尋常型銀屑病患者皮損中IL-22與IL-22R1、STAT3、c-myc的mRNA表達及關系研究[J];北京中醫(yī)藥大學學報;2015年08期

5 周倩;郝平生;馬可芹;李嬌慧;尤雯麗;;尋常型銀屑病中Notch信號通路的研究前景[J];中國中西醫(yī)結合雜志;2014年12期

6 ;尋常型銀屑病(白u，

本文編號：2128388