本文選題：銀屑病 + 高壓氧��； 參考：《中國皮膚性病學(xué)雜志》2014年03期

【摘要】：目的觀察高壓氧聯(lián)合注射用復(fù)方甘草酸苷治療進行期尋常性銀屑病前后外周血T細胞亞群的變化情況,并觀察臨床療效。方法選取60例進行期尋常性銀屑病患者,隨機分為對照組、治療組,每組各30例。對照組每日靜滴注射用復(fù)方甘草酸苷80mg,治療組每日靜滴復(fù)方甘草酸苷80mg+1次高壓氧艙治療,各組療程均為4周。另選30例健康人群作為健康對照組。結(jié)果與健康對照組比較,進行期尋常性銀屑病患者CD4+T細胞水平、CD4+/CD8+顯著降低(P0.05),CD8+T細胞水平顯著升高(P0.05);與治療組治療前比較,經(jīng)高壓氧聯(lián)合復(fù)方甘草酸苷治療后,CD4+T細胞水平、CD4+/CD8+均有顯著升高,CD8+T細胞水平顯著降低(P0.05),臨床總有效率達(93.3%)。結(jié)論高壓氧聯(lián)合復(fù)方甘草酸苷治療對進行期尋常性銀屑病療效肯定,其機制可能與糾正患者外周血T細胞亞群的失衡狀態(tài)有關(guān)。
[Abstract]:Objective to observe the changes of T cell subsets in peripheral blood of patients with psoriasis vulgaris before and after hyperbaric oxygen and injection of compound glycyrrhizin. Methods 60 patients with psoriasis vulgaris were randomly divided into control group (n = 30) and treatment group (n = 30). The control group was given 80 mg of compound glycyrrhizin by intravenous drip daily, and the treatment group was treated with hyperbaric oxygen chamber once a day by intravenous drip of compound glycyrrhizin 80mg. The course of treatment in each group was 4 weeks. Another 30 healthy people were selected as healthy control group. Results compared with the healthy control group, the level of CD4 / CD8 in patients with psoriasis vulgaris was significantly lower than that in the control group, and the level of CD4 / CD8 was significantly increased in patients with psoriasis vulgaris than that in the control group, and was significantly higher in patients with psoriasis vulgaris than before treatment. After hyperbaric oxygen combined with compound glycyrrhizin treatment, the level of CD4 / CD8 increased significantly and the level of CD8 T cells decreased significantly, and the total clinical effective rate reached 93.3%. Conclusion Hyperbaric oxygen combined with compound glycyrrhizin is effective in the treatment of psoriasis vulgaris, and its mechanism may be related to correcting the imbalance of T cell subsets in peripheral blood of patients with psoriasis vulgaris.
【作者單位】： 綿陽市中心醫(yī)院皮膚科;西安交通大學(xué)醫(yī)學(xué)院第二附屬醫(yī)院皮膚科;
【基金】：四川省綿陽市衛(wèi)生局科研立項項目(201222)
【分類號】：R758.63

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本文編號：2003058