本文選題：天皰瘡 + Th細(xì)胞��； 參考：《中國(guó)皮膚性病學(xué)雜志》2016年06期

【摘要】：目的探討Th1,Th2,Th17和Treg細(xì)胞與尋常型天皰(PV)發(fā)病的相關(guān)性。方法天皰瘡患者29例(活動(dòng)組18例,緩解組11例),對(duì)照組14例,采用流式細(xì)胞術(shù)檢測(cè)外周血Th1,Th2,Treg和Th17細(xì)胞占CD4~+T淋巴細(xì)胞的比例,用SPSS17.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果活動(dòng)組PV的Th17細(xì)胞百分比(6.73±2.29)%顯著高于緩解組(3.08±0.91)%和對(duì)照組(0.18±0.10)%(P0.05);緩解組PV的Th17細(xì)胞百分比高于對(duì)照組(P0.05);PV活動(dòng)組(1.70±0.87)%、緩解組(1.28±0.58)%和對(duì)照組(1.46±0.63)%,三組間的Treg細(xì)胞百分比差異無統(tǒng)計(jì)學(xué)意義(P0.05)�；顒�(dòng)組PV的Th1細(xì)胞百分比(8.68±1.77)%低于對(duì)照組(12.29±1.57)%和緩解組(10.88±2.98)%(P0.05),Th1細(xì)胞在對(duì)照組與緩解組PV中的差異無統(tǒng)計(jì)學(xué)意義(P0.05)。PV活動(dòng)組Th2細(xì)胞百分比(2.86±0.79)%高于對(duì)照組(0.41±0.39)%和緩解組(0.99±0.45)%(P0.05),緩解組的Th2細(xì)胞高于對(duì)照組(P0.05)。結(jié)論天皰瘡患者外周血Th17,Th2細(xì)胞表達(dá)升高,Th1細(xì)胞表達(dá)降低,Treg細(xì)胞表達(dá)無異常。Th1,Th2和Th17細(xì)胞可能參與了天皰瘡的發(fā)病過程。
[Abstract]:Objective to investigate the correlation between Th1, Th2, Th17 and Treg cells and the onset of pemphigus vulgaris (PV). Methods 29 patients with pemphigus (18 in the active group, 11 in the remission group) and 14 in the control group were examined by flow cytometry to detect the proportion of Th1, Th2, Treg and Th17 cells to CD4~+T lymphocytes, and the statistical analysis was carried out by SPSS17.0 statistical software. The percentage of Th17 cells in group PV (6.73 + 2.29)% was significantly higher than that in the remission group (3.08 + 0.91)% and the control group (0.18 + 0.10)% (P0.05), and the percentage of Th17 cells in the remission group was higher than that in the control group (P0.05), the PV activity group (1.70 + 0.87)%, the remission group (1.28 + 0.58)% and the control group (1.46 + 0.63)%, and there was no significant difference in the percentage of Treg cells between the three groups (P0.05). The percentage of Th1 cells in the active group PV (8.68 + 1.77)% was lower than that of the control group (12.29 + 1.57)% and remission group (10.88 + 2.98)% (P0.05). There was no significant difference between the Th1 cells in the control group and the remission group (P0.05).PV activity group (2.86 + 0.79)% (0.41 + 0.39)% and remission group (0.41 + 0.39)% (0.99 + 0.45)% (P0.05), and Th2 in the remission group. The cells were higher than the control group (P0.05). Conclusion the expression of Th17, Th2 cells in the peripheral blood of pemphigus patients increased, the expression of Th1 cells decreased, and the expression of Treg cells had no abnormal.Th1. Th2 and Th17 cells may be involved in the pathogenesis of pemphigus.
【作者單位】： 昆明醫(yī)科大學(xué)第二附屬醫(yī)院風(fēng)濕免疫科;勝利油田中心醫(yī)院皮膚科;
【基金】：云南省聯(lián)合專項(xiàng)基金(2012FB059)
【分類號(hào)】：R758.66
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本文編號(hào)：2003018