本文選題：尖銳濕疣 + 人乳頭瘤病毒��； 參考：《中國病原生物學(xué)雜志》2017年07期

【摘要】：目的分析女性尖銳濕疣(CA)患者人乳頭瘤病毒(HPV)的感染情況及基因分型,探討HPV基因型與CA預(yù)后的關(guān)系。方法臨床確診女性CA初發(fā)患者(CA組)230例,采用導(dǎo)流雜交基因芯片技術(shù)(HybriMax)進行HPVDNA及基因分型檢測。HPV-DNA陽性患者根據(jù)HPV基因型分為高危型、低危型和混合型3組,另選健康女性作為對照,分析HPV-DNA陽性CA患者治療前后外周血T淋巴細胞亞群變化并與健康人進行比較;觀察不同HPV基因型CA患者治療后1、3、6個月的復(fù)發(fā)情況。結(jié)果 CA患者HPV-DNA陽性率為95.22%(219/230)。HPV-DNA陽性標本中共檢出21種HPV基因型,其中HPV16(7.83%)和HPV6(29.57%)分別在高危型和低危型HPV中陽性率高。治療前不同HPV基因型CA患者的CD_3~+、CD_4~+T淋巴細胞百分比及CD_4~+/CD8+比值均顯著低于健康對照組(P0.05),CD8+T淋巴細胞百分比顯著高于健康對照組(P0.05);治療后不同HPV基因型CA患者的CD_3~+、CD_4~+T淋巴細胞百分比及CD_4~+/CD8+比值均較治療前顯著升高(P0.05),CD8+T淋巴細胞百分比顯著降低(P0.05);治療前后各HPV基因型組間T淋巴細胞亞群百分率差異無統(tǒng)計學(xué)意義(P0.05)。高危型患者治療后3個月和6個月復(fù)發(fā)率分別為12.17%和15.65%,與低危型組的4.78%、6.52%和混合型組的5.56%、8.26%比較差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論女性CA患者HPV感染以HPV6、HPV11及HPV16 3種基因型為主,高危型和低危型HPV可單一感染也可混合感染。CA患者細胞免疫功能失調(diào)與HPV基因分型無關(guān),但高危型HPV感染患者治療后復(fù)發(fā)率更高。
[Abstract]:Objective to analyze the infection and genotyping of human papillomavirus (HPV) in female patients with condyloma acuminatum (CA), and to explore the relationship between HPV genotype and prognosis of CA. Methods two hundred and thirty female patients with primary CA were divided into high risk group, low risk group and mixed type group according to their HPV genotypes. The changes of T lymphocyte subsets in peripheral blood of patients with HPV-DNA positive CA before and after treatment were analyzed and compared with those of healthy subjects. The recurrence of CA patients with different HPV genotypes was observed 1 and 6 months after treatment. Results the positive rate of HPV-DNA in CA patients was 21 HPV genotypes detected in 95.22%(219/230).HPV-DNA positive specimens. HPV167.83) and HPV6 + 29.57) were detected in high risk type and low risk type HPV, respectively. The percentage of CD3 ~ T lymphocytes and the ratio of CD4 ~ / CD8 to CD4 / CD8 in CA patients with different HPV genotypes before treatment were significantly lower than those in healthy controls, and the percentage of CD3 ~ T lymphocytes in CA patients with different HPV genotypes after treatment was significantly higher than that in healthy controls. The percentage of CD3 ~ T lymphocytes and the ratio of CD4 ~ / CD8 were significantly higher than those before treatment, but the percentage of T lymphocyte subsets in all HPV genotypes before and after treatment was significantly lower than that before treatment (P0.05), and there was no significant difference in the percentage of T lymphocyte subsets between different HPV genotypes before and after treatment. The recurrence rates of high risk patients at 3 and 6 months after treatment were 12.17% and 15.65%, respectively, which were significantly different from those of low risk group (4.78%, 6.52%) and mixed group (5.56%, 8.26%). Conclusion HPV6, HPV11 and HPV16 are the main genotypes of HPV infection in female patients with CA. High risk type and low risk type HPV can be single infection or mixed infection. There is no relationship between cellular immune dysfunction and HPV genotyping in CA patients. However, the recurrence rate of high-risk HPV infection patients was higher after treatment.
【作者單位】： 華中科技大學(xué)同濟醫(yī)學(xué)院附屬武漢中心醫(yī)院皮膚科;
【分類號】：R440;R752.53

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相關(guān)期刊論文 前6條

1 陳思華;楊健;楊文林;;臨床尖銳濕疣流行病學(xué)與復(fù)發(fā)的相關(guān)危險因素的研究[J];中國性科學(xué);2015年07期

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本文編號：1929951