本文選題：脈沖射頻 + 背根神經(jīng)節(jié)�。� 參考：《吉林大學(xué)》2017年碩士論文

【摘要】：目的:研究背根神經(jīng)節(jié)脈沖射頻術(shù)聯(lián)合椎間孔注射臭氧及復(fù)合液的綜合治療帶狀皰疹后神經(jīng)痛的有效性及安全性,為帶狀皰疹后神經(jīng)痛的治療提供一種療效好、痛苦少的治療方案。方法:選取胸、腹背部的帶狀皰疹后神經(jīng)痛(PHN)患者62例,隨機(jī)分成實驗組(32例)和對照組(30例)。對照組:應(yīng)用CT引導(dǎo)下背根神經(jīng)節(jié)脈沖射頻術(shù)聯(lián)合椎間孔注射復(fù)合液治療;實驗組:應(yīng)用CT引導(dǎo)下背根神經(jīng)節(jié)脈沖射頻術(shù)聯(lián)合椎間孔注射復(fù)合液及臭氧治療。應(yīng)用簡式McGill疼痛問卷表(short-form of McGill pain questionnaire,SF-MPQ)觀察記錄兩組患者術(shù)前、術(shù)后不同時間段的疼痛評定指數(shù)(pain rating index,PRI)、視覺模擬評分(visual analogue score,VAS)、現(xiàn)時疼痛強(qiáng)度(present pain intensity,PPI)及SF-MPQ隨時間變化情況,同時比較兩組間的差異。結(jié)果:兩組間性別、年齡及病程差異無統(tǒng)計學(xué)意義(P0.05),且兩組間術(shù)前PRI、VAS、PPI及SF-MPQ差異也無統(tǒng)計學(xué)意義(P0.05)。兩組患者在術(shù)后7天、1個月、3個月及12個月時SF-MPQ中各項指標(biāo)的評分均下降,與術(shù)前比較差異有統(tǒng)計學(xué)意義(P0.05)。在組內(nèi)比較中,兩組術(shù)后7天、1個月、3個月的各評價指標(biāo)之間比較有顯著差異(P0.001),但術(shù)后3個月與12個月比較差異無統(tǒng)計學(xué)意義(P0.05)。組間比較中,實驗組在術(shù)后各時間段的PRI、VAS、SF-MPQ以及術(shù)后7天、1個月的PPI的評分均下降明顯高于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。但實驗組與對照組術(shù)后3個月、12個月的PPI評分無統(tǒng)計學(xué)差異。兩組均未出現(xiàn)與本研究相關(guān)的不良反應(yīng)及不良事件發(fā)生。結(jié)論:兩種鎮(zhèn)痛治療方案均能有效緩解帶狀皰疹后神經(jīng)痛患者的劇烈疼痛;CT引導(dǎo)下背根神經(jīng)節(jié)脈沖射頻術(shù)聯(lián)合復(fù)合液+臭氧治療更能快速而顯著緩解帶狀皰疹后神經(jīng)痛。
[Abstract]:Objective: to study the efficacy and safety of pulse radiofrequency of dorsal root ganglion (DRG) combined with intervertebral foramen injection of ozone and compound solution in the treatment of postherpetic neuralgia, and to provide a good curative effect for the treatment of postherpetic neuralgia. A less painful treatment. Methods: 62 patients with postherpetic neuralgia were randomly divided into experimental group (n = 32) and control group (n = 30). The control group was treated with CT-guided pulsed-radiofrequency of dorsal root ganglion (DRG) combined with intervertebral foramen injection of compound fluid, while the experimental group was treated with CT-guided RFA combined with intervertebral foramen injection of composite fluid and ozone therapy. Using short-form of McGill pain questionnaire SF-MPQs, the pain rating index and visual analogue scale (VAS) were observed and recorded in two groups of patients before and after operation. The visual analogue score (VAS) and the present pain intensity (PPI) and SF-MPQ (SF-MPQ) were measured over time. The differences between the two groups were also compared. Results: there was no significant difference in sex, age and course of disease between the two groups, and there was no significant difference in PPI and SF-MPQ between the two groups before operation. After 7 days, 1 month, 3 months and 12 months after operation, the scores of SF-MPQ in the two groups were significantly lower than those before operation (P 0.05). In the intra-group comparison, there was significant difference between the two groups on the 7th day, the 1st month and the 3rd month after operation (P 0.001), but there was no significant difference between the 3 months and 12 months after the operation (P 0.05). Compared with the control group, the PPI scores of the experimental group were significantly lower than those of the control group at each time after operation, and at 7 days after operation, the difference was statistically significant (P 0.05). However, there was no significant difference in PPI score between the experimental group and the control group at 3 months and 12 months after operation. There were no adverse reactions and adverse events related to this study in both groups. Conclusion: both of the two analgesic treatments can effectively relieve severe pain in patients with postherpetic neuralgia. CT-guided pulsed radiofrequency ablation of dorsal root ganglion combined with ozone combined with liquid ozone can relieve postherpes neuralgia more quickly and significantly.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R752.12

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