本文選題：梅毒 + 紅細胞　； 參考：《蘭州大學》2010年碩士論文

【摘要】： 梅毒是由梅毒螺旋體引起的一種危害性極大的慢性傳染病,主要通過性接觸和血液傳播。梅毒的發(fā)病機制未完全闡明,出現(xiàn)血清固定的確切原因目前尚不清楚。當前對梅毒發(fā)病機制和血清固定原因的研究主要集中在白細胞免疫,認為梅毒發(fā)病與T細胞介導的免疫反應密切相關。近年來紅細胞免疫逐漸成為感染性疾病的研究熱點之一,有研究表明梅毒感染者的紅細胞免疫功能較正常人明顯降低,但關于梅毒患者CR1密度相關基因多態(tài)性的研究尚未見報道。 目的探討梅毒患者紅細胞CR1密度相關基因型的頻率分布。 方法采用聚合酶鏈反應(PCR)、限制性內(nèi)切酶HindⅢ酶切技術測定患者紅細胞CR1密度相關基因多態(tài)性。 結果病例組中CR1基因HH、HL和LL基因型分布頻率分別為58.75%、35%、和6.25%,對照組中HH、HL和LL基因型分布頻率分別為68.75%、26.25%和5%,兩組CR1基因型的分布頻率差異無顯著性(p0.05)；梅毒患者組基因突變率為41.25%,對照組為31.25%,也無顯著性差異(p0.05)。 結論梅毒患者的紅細胞免疫功能低下與紅細胞CR1基因發(fā)生突變關系不密切。
[Abstract]:Syphilis is a serious chronic infectious disease caused by Treponema pallidum, mainly through sexual contact and blood transmission. The pathogenesis of syphilis is not fully clarified, and the exact cause of serum fixation is unclear. At present, the pathogenesis of syphilis and the cause of serum fixation are mainly focused on leukocyte immunity. It is believed that the pathogenesis of syphilis is closely related to T cell mediated immune response. In recent years, red blood cell immunity has gradually become one of the hotspots in infectious diseases. Some studies have shown that the red cell immune function of syphilis infected people is significantly lower than that of normal people. However, the study of CR1 density related gene polymorphism in syphilis patients has not been reported. Objective to investigate the frequency distribution of erythrocyte CR1 density related genotypes in syphilis patients. Methods Polymerase chain reaction (PCR) and restriction endonuclease (Hind 鈪，

本文編號：1819477