面部糖皮質(zhì)激素依賴性皮炎危險(xiǎn)因素及發(fā)病與情緒變化的相互關(guān)系研究
發(fā)布時(shí)間:2018-04-16 19:43
本文選題:激素依賴性皮炎 + 危險(xiǎn)因素 ; 參考:《成都中醫(yī)藥大學(xué)》2010年碩士論文
【摘要】:目的: 探討面部糖皮質(zhì)激素依賴性皮炎與患者情緒之間的相互影響關(guān)系,并分析該病發(fā)生、加重、遷延不愈的相關(guān)因素;尋找傳統(tǒng)中醫(yī)情志理論與現(xiàn)代心理學(xué)的共通處,運(yùn)用中醫(yī)辨證論治,將心理疏導(dǎo)與中醫(yī)藥物治療結(jié)合起來,讓患者接受治療,自信治療,堅(jiān)持治療,從而真正達(dá)到治愈該病的最終目的。 方法: 采用成組病例-對(duì)照設(shè)計(jì),回顧性調(diào)查方式,對(duì)50例依賴性皮炎患者和50例未患依賴性皮炎者進(jìn)行相關(guān)病史問卷調(diào)查以及SCL-90癥狀自評(píng)。用Excel2003建立數(shù)據(jù)庫(kù),采用SPSS 13.0完成統(tǒng)計(jì)分析。 結(jié)果: 1.發(fā)病危險(xiǎn)因素統(tǒng)計(jì)結(jié)果: 用藥時(shí)間(Wald值=9.427,P=0.024,<0.05)、重疊用藥(B=5.547,OR=256.371,P=0.000)是GDD的危險(xiǎn)因素。 2.病例組與對(duì)照組之間Scl-90評(píng)分差異: (1)總分及9項(xiàng)情緒因子均比對(duì)照組高,其中強(qiáng)迫癥狀(Z=-1.953,P=-0.051,)可能與樣本量小有關(guān),但該項(xiàng)病例組中位數(shù)大于對(duì)照組,提示病例組強(qiáng)迫癥狀略明顯于對(duì)照組;其他各項(xiàng)情緒因子比較(均P<0.05)。 (2)扣除年齡影響后,病例組陽(yáng)性項(xiàng)目數(shù)確實(shí)高于對(duì)照組(P<0.05) (3)病例組SCL-90情緒癥狀陽(yáng)性率高于對(duì)照組(x2=14.924,P=O.000)。 (4)病例組軀體化、強(qiáng)迫癥狀、抑郁、焦慮、敵對(duì)、恐怖、精神病性的程度重于對(duì)照組(P均<0.05)。 3.各證型與對(duì)照組比較: 氣血兩燔組人際關(guān)系敏感、抑郁、焦慮、敵對(duì)、恐怖、精神病性嚴(yán)重于對(duì)照組(均P<0.0125);血分證焦慮、恐怖癥狀比對(duì)照組較重(均P<0.0125)。 4網(wǎng)絡(luò)組SCL-90各情緒因子分明均顯高于對(duì)照組(均P<0.025)。 5不同病程與對(duì)照組比較: (1)病程T≤1年者比對(duì)照組不良情緒軀體化、焦慮、敵對(duì)、恐怖重(均P<0.0167)。 (2)病程T2年者比對(duì)照組強(qiáng)迫癥狀、人際關(guān)系敏感、抑郁、焦慮、敵對(duì)、恐怖、精神病性重(P值均<0.0167)。 6.病例組內(nèi)比較: (1)不同來源病例中醫(yī)證型分布相同(P均>0.05)。 (2)各證型之間情緒癥狀相同(P均>0.0083)。 (3)網(wǎng)絡(luò)患者比門診患者的9項(xiàng)情緒因子分均高(P<0.05)。 (4)病程與SCL-90各項(xiàng)評(píng)分無(wú)線性相關(guān)(P>0.05)。T≤1年、T2分別與1年<T≤2年比較,差異均反映在焦慮情況上,均比1年<T≤2年者明顯(均P<0.0167)。 結(jié)論: 1用藥時(shí)間和重疊用藥是GDD發(fā)病危險(xiǎn)因素。 2 GDD患者在情緒變化上比非GDD人群更顯著。 3中醫(yī)辨證體系對(duì)情緒異常的認(rèn)識(shí)與患者臨床上所表現(xiàn)出的相符合。 4網(wǎng)絡(luò)患者的情緒變化更重。 5病程與情緒無(wú)直線相關(guān)關(guān)系,但急性發(fā)病、久病者的不良情緒明顯嚴(yán)重。
[Abstract]:Objective:To explore the relationship between facial glucocorticoid dependent dermatitis and patients' emotions, and to analyze the related factors of occurrence, aggravation and immortality of the disease, and to find common ground between traditional Chinese medicine emotional theory and modern psychology.Using TCM syndrome differentiation and treatment, the psychological dredging and traditional Chinese medicine treatment are combined to make patients accept treatment, self-confident treatment, insist treatment, so as to truly achieve the ultimate goal of curing the disease.Methods:A case-control design was used to investigate 50 patients with dependent dermatitis and 50 patients with non-dependent dermatitis by questionnaire survey and self-evaluation of SCL-90 symptoms.Excel2003 was used to establish database and SPSS 13.0 was used to complete statistical analysis.Results:1.Statistical results of risk factors:The time of drug use was 9.427m, 0.024, < 0.05U, and the superimposed drug was 5.547 (256.371P0.000), which was the risk factor of GDD.2.The difference of Scl-90 score between the case group and the control group:(1) the total score and 9 emotion factors were higher than those in the control group. The obsessive-compulsive symptoms were probably related to the sample size, but the median of the case group was higher than that of the control group, suggesting that the obsessive-compulsive symptom in the case group was slightly more than that in the control group.Other emotional factors were compared (all P < 0.05).(2) after deducting the influence of age, the number of positive items in the case group was indeed higher than that in the control group (P < 0.05).3) the positive rate of SCL-90 emotional symptoms in the case group was higher than that in the control group.4) somatization, obsessive-compulsive symptoms, depression, anxiety, hostility, phobia and psychosis in the case group were more severe than those in the control group (P < 0.05).3.Compared with the control group, each syndrome type:The sensitivity of interpersonal relationship, depression, anxiety, hostility, phobia and psychosis in Qi-blood two burnt group were more serious than those in control group (all P < 0.0125, P < 0.0125), and the anxiety and phobic symptoms in blood differentiation syndrome were more serious than those in control group (all P < 0.0125).4 SCL-90 emotional factors in the network group were significantly higher than those in the control group (P < 0.025).5Compared with control group in different course of disease.The course of disease T 鈮,
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