本文選題：皮膚腫瘤　切入點(diǎn)：Merkel細(xì)胞癌　出處：《臨床與實(shí)驗(yàn)病理學(xué)雜志》2017年03期 　論文類型：期刊論文

【摘要】：目的 探討皮膚Merkel細(xì)胞癌(Merkel cell carcinoma,MCC)的臨床病理特征、免疫表型、診斷和鑒別診斷。方法回顧性分析2例MCC的臨床及病理學(xué)特點(diǎn),并復(fù)習(xí)相關(guān)文獻(xiàn)。結(jié)果 2例患者均為老年男性,全身腫瘤多發(fā),鏡下見2例腫瘤主要位于真皮及皮下組織,未侵及表皮,腫瘤組織均由大小較一致的腫瘤細(xì)胞彌漫呈片、巢狀分布,瘤細(xì)胞體積較小,胞質(zhì)稀少,核圓形或橢圓形,深染,核膜清楚,核仁不明顯,核分裂象易見,并可見神經(jīng)浸潤(rùn)現(xiàn)象。免疫組化標(biāo)記示上皮和神經(jīng)內(nèi)分泌分化陽(yáng)性,例1 CK20呈特征性的核旁點(diǎn)狀陽(yáng)性,例2 CK7陽(yáng)性/CK20陰性在MCC中較為少見。結(jié)論MCC惡性程度高,臨床較為罕見,應(yīng)與其他小細(xì)胞腫瘤鑒別。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of cell carcinoma of Merkel cell carcinoma of skin. Methods the clinical and pathological features of 2 cases of MCC were retrospectively analyzed and the relevant literature was reviewed. The tumors were mostly located in dermis and subcutaneous tissue, but not in epidermis. The tumor tissues were all distributed in the same size, the tumor cells were small in size, and the cytoplasm was rare, and the tumor tissues were mainly located in the dermis and subcutaneous tissues, but not in the epidermis. The nucleus was round or ellipse, deep stained, clear nuclear membrane, not obvious nucleolus, mitotic image, and the phenomenon of nerve infiltration. Immunohistochemical staining showed that the epithelial and neuroendocrine differentiation was positive. In case 1, CK20 showed characteristic parafronucleus dot positive. Case 2 CK7 positive / CK20 negative was rare in MCC. Conclusion MCC is highly malignant and rare in clinical practice, and should be distinguished from other small cell tumors.
【作者單位】： 山東大學(xué)附屬省立醫(yī)院病理科;解放軍總醫(yī)院第一附屬醫(yī)院病理科;
【分類號(hào)】：R739.5

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