本文選題：脊柱炎 + 強(qiáng)直性��； 參考：《中國組織工程研究》2017年11期

【摘要】：背景:強(qiáng)直性脊柱炎是以侵犯中軸關(guān)節(jié)為主的慢性炎癥自身免疫性疾病,目前發(fā)病機(jī)制仍不明確。需要進(jìn)行深入的研究,穩(wěn)定和成熟的動(dòng)物模型顯得更加重要。強(qiáng)直性脊柱炎脊柱和骶髂生物樣本非常的稀缺,然而學(xué)者們對該病發(fā)病機(jī)制的理解很大程度上依賴于強(qiáng)直性脊柱炎動(dòng)物模型的研究成果,目前的幾種強(qiáng)直性脊柱炎動(dòng)物模型均無法很好的代表強(qiáng)直性脊柱炎的病理病程。目的:通過總結(jié)以往各類強(qiáng)直性脊柱炎動(dòng)物模型臨床和病理特征,為進(jìn)一步完善此類動(dòng)物模型提供基礎(chǔ)。方法:以("Ankylosing Spondylitis"AND"Animal Models")OR("HLA-B27"AND"Animal models")為英文檢索詞,以("強(qiáng)直性脊柱炎"AND"動(dòng)物模型"OR("人類白細(xì)胞抗原B27"AND"動(dòng)物模型")為中文檢索詞,通過檢索Pub Med/CNKI數(shù)據(jù)庫,排除臨床新藥研究、動(dòng)物模型僅為研究手段及未涉及動(dòng)物模型機(jī)制探討的文章。對目前常見的強(qiáng)直性脊柱炎動(dòng)物模型發(fā)病機(jī)制、病理特征進(jìn)行歸納總結(jié)。結(jié)果與結(jié)論:納入綜述的文章為37篇。把目前現(xiàn)有的幾種強(qiáng)直性脊柱炎動(dòng)物模型歸為3大類,各類動(dòng)物模型各有其優(yōu)缺點(diǎn),它們均能模擬強(qiáng)直性脊柱炎的某些發(fā)病特征,但是仍缺乏強(qiáng)直性脊柱炎最具代表性的動(dòng)物模型,考慮到強(qiáng)直性脊柱炎的發(fā)病與腸道菌群密切相關(guān),并將各類動(dòng)物模型的發(fā)病特與之結(jié)合,有望復(fù)制出更加穩(wěn)定和完善的強(qiáng)直性脊柱炎動(dòng)物模型。
[Abstract]:Background: ankylosing spondylitis (ankylosing spondylitis) is a chronic autoimmune disease which mainly invades the axial joint. The pathogenesis of ankylosing spondylitis is still unclear. Stable and mature animal models need to be studied in depth. The spine and sacroiliac biological samples of ankylosing spondylitis are scarce, but scholars' understanding of the pathogenesis of the disease depends to a large extent on the results of animal models of ankylosing spondylitis. Several animal models of ankylosing spondylitis can not represent the pathological course of ankylosing spondylitis. Objective: to summarize the clinical and pathological features of various animal models of ankylosing spondylitis. Methods: using "Ankylosing Spondylitis" and "Animal models" OR ("HLA-B27" and "Animal models") as the English key word, or (the animal model of "ankylosing spondylitis" and "animal model of human leukocyte antigen B27" and "animal model of human leukocyte antigen B27") as the Chinese key word. Animal model is only a research method and does not involve the discussion of animal model mechanism. The pathogenesis and pathological features of common animal models of ankylosing spondylitis were summarized. Results & conclusion: 37 articles were included in the review. The present animal models of ankylosing spondylitis are classified into three categories. Each animal model has its own advantages and disadvantages, and they can all simulate some characteristics of ankylosing spondylitis. However, there is still a lack of the most representative animal models of ankylosing spondylitis. Considering that the incidence of ankylosing spondylitis is closely related to the intestinal flora, It is expected to replicate a more stable and perfect animal model of ankylosing spondylitis.
【作者單位】： 廣州中醫(yī)藥大學(xué)第二臨床醫(yī)學(xué)院;廣東省中醫(yī)藥科學(xué)院;廣東省中醫(yī)院新藥開發(fā)辦;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81273736,81673898)~~
【分類號】：R-332;R593.23

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