膀胱不同部位注射A型肉毒素治療女性難治性膀胱過度活動癥的臨床研究
[Abstract]:Objective to observe the effect of botulinum toxin type A injection into different parts of bladder in the treatment of refractory bladder hyperactivity in women. Methods 40 patients were randomly divided into detrusor injection group (group A) and detrusor combined with triangular injection group (group B). The clinical symptoms of the patients before and 4 weeks after treatment (average daily urination times) were evaluated. Average urination volume, nocturnal urine frequency, urination urgency times), urodynamic indexes (initial urinary bladder volume, maximum bladder volume), OABSS score, QOL score. Results after 4 weeks of botulinum toxin A injection treatment, the average daily urination times, average daily urination volume, nocturnal urine frequency, urination urgency times, OABSS score and QOL score in group A were average daily urination times, average urination volume per day, nocturnal urine frequency, urination urgency times, OABSS score and QOL score. The maximum bladder volume was significantly improved compared with group B (P 0.05). Conclusion intravesical injection of botulinum toxin A is effective in the treatment of refractory bladder hyperactivity without obvious toxic and side effects. It is an economical and effective new method for the treatment of refractory bladder hyperactivity. The symptom relief is more obvious by injection of detrusor combined with triangular area, which is worthy of further study and promotion.
【作者單位】: 南方醫(yī)科大學附屬佛山婦幼保健院外科;廣東省廣州市第一人民醫(yī)院泌尿外科;
【基金】:廣東省衛(wèi)生廳指令性課題(C2013014) 佛山市科技局基金項目(201308077)
【分類號】:R694
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