【摘要】：目的:探討貝前列腺素鈉聯(lián)合氯吡格雷對(duì)尿毒癥患者動(dòng)靜脈內(nèi)瘺手術(shù)成功率的影響。方法:回顧性分析動(dòng)靜脈內(nèi)瘺手術(shù)后建立長(zhǎng)期血管通路的345例患者的臨床資料,按治療方法的不同隨機(jī)分為觀察組(180例)和對(duì)照組(165例)。對(duì)照組患者給予常規(guī)護(hù)理和治療;觀察組患者在對(duì)照組治療的基礎(chǔ)上給予貝前列素鈉片40μg、口服、tid+氯吡格雷75 mg、首次劑量300 mg、晨服。兩組患者療程均為1個(gè)月。觀察兩組患者動(dòng)靜脈內(nèi)瘺手術(shù)成功率,術(shù)后內(nèi)瘺成熟首次使用時(shí)間、平均內(nèi)瘺血流量,治療前后凝血酶原時(shí)間、血壓及不良反應(yīng)發(fā)生情況。結(jié)果:觀察組患者動(dòng)靜脈內(nèi)瘺手術(shù)成功率顯著高于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組患者術(shù)后內(nèi)瘺成熟首次使用時(shí)間顯著短于對(duì)照組,平均內(nèi)瘺血流量顯著高于對(duì)照組,兩組比較差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。兩組患者治療前后凝血酶原時(shí)間及血壓比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者治療期間均未見(jiàn)明顯不良反應(yīng)發(fā)生。結(jié)論:貝前列腺素鈉聯(lián)合氯吡格雷可提高尿毒癥患者動(dòng)靜脈內(nèi)瘺手術(shù)成功率,縮短術(shù)后內(nèi)瘺成熟首次使用時(shí)間,增加內(nèi)瘺血流量,且安全性較好。
[Abstract]:Objective: to investigate the effect of beprostaglandin sodium combined with clopidogrel on the success rate of arteriovenous fistula in uremic patients. Methods: the clinical data of 345 patients who established long-term vascular access after arteriovenous fistula operation were retrospectively analyzed and randomly divided into observation group (180 cases) and control group (165 cases). The patients in the control group were given routine nursing care and treatment, the patients in the observation group were given berprostatin sodium tablets 40 渭 g, oral tid clopidogrel 75 mg, initial dose 300 mg, morning administration on the basis of the treatment in the control group. The course of treatment was 1 month in both groups. The successful rate of arteriovenous fistula operation, the first time of maturation of internal fistula, the mean blood flow of internal fistula, the prothrombin time, blood pressure and adverse reactions were observed before and after treatment. Results: the success rate of arteriovenous fistula in the observation group was significantly higher than that in the control group, and the difference between the two groups was statistically significant (P0.05). The first time of maturation of internal fistula in the observation group was significantly shorter than that in the control group, and the mean blood flow of the fistula was significantly higher in the observation group than in the control group, and the difference between the two groups was statistically significant (P0.01). There was no significant difference in prothrombin time and blood pressure between the two groups before and after treatment (P0.05). No significant adverse reactions occurred during treatment in both groups. Conclusion: Beprostaglandin sodium combined with clopidogrel can improve the success rate of operation of arteriovenous fistula in uremic patients, shorten the first time of maturation of postoperative internal fistula, increase blood flow of internal fistula, and have good safety.
【作者單位】： 綿陽(yáng)市中心醫(yī)院腎內(nèi)科;
【分類(lèi)號(hào)】：R692.5

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本文編號(hào)：2134266