本文選題：非淋球菌性尿道炎 + 支原體感染　； 參考：《中華醫(yī)院感染學(xué)雜志》2017年03期

【摘要】：目的探究醫(yī)院非淋球菌性尿道炎患者支原體感染和耐藥狀況,以期臨床治療提供參考。方法選取2013年1月-2015年12月醫(yī)院收治152例非淋球菌性尿道炎患者為研究對象,均進行支原體培養(yǎng)和藥敏檢測,并分析支原體對各類抗菌藥物的耐藥性變遷。結(jié)果 2013-2015年間支原體培養(yǎng)陽性率逐年升高,但各類支原體所占比例無顯著變化,大部分為Uu,其次為Uu+Mh,Mh最少;2013年-2015年間不同支原體來源由高到低為宮頸分泌物、男性尿道分泌物;女性支原體感染率顯著高于男性;支原體感染率最高的年齡段為21~30歲,其次為31~40歲,差異有統(tǒng)計學(xué)意義(P0.05);2013-2015年Uu+Mh對多西環(huán)素、米諾環(huán)素、克雷霉素、交沙霉素,Uu對環(huán)丙沙星的耐藥率變化差異無統(tǒng)計學(xué)意義;2013-2015年Uu+Mh和Uu對多諾環(huán)素、環(huán)酯紅霉素、阿奇霉素、克拉霉素、羅紅霉素、紅霉素、左氧氟沙星、司帕沙星、甲砜霉素等耐藥性逐年增高,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論支原體感染多發(fā)于年齡21~30歲女性,且發(fā)病率逐年增高,對各類常用抗菌藥物的耐藥性也逐年增高,多西環(huán)素、米諾環(huán)素、交沙霉素成為治療的首選藥物,臨床中可依據(jù)支原體培養(yǎng)和藥敏檢測選擇適當(dāng)?shù)目咕幬镞M行治療。
[Abstract]:Objective to investigate mycoplasma infection and drug resistance in patients with nongonococcal urethritis. Methods 152 patients with nongonococcal urethritis treated in our hospital from January 2013 to December 2015 were studied. Mycoplasma culture and antimicrobial susceptibility were detected, and the changes of drug resistance of mycoplasma to various antimicrobial agents were analyzed. Results the positive rate of mycoplasma culture increased year by year from 2013 to 2015, but the proportion of mycoplasma was not significantly changed, most of them were Uuu, followed by UU Mhmeng Mh. From 2013 to 2015, different mycoplasma sources from high to low were cervical secretions. The infection rate of urethral secretion in male was significantly higher than that in male. The highest rate of mycoplasma infection was in the age group of 21 ~ 30 years old, followed by 31 ~ 40 years old. The difference was statistically significant (P 0.05). The UU Mh of doxycycline, minocycline, clemycin from 2013 to 2015 was significantly higher than that of male. There was no significant difference in drug resistance of roxithromycin Uu to ciprofloxacin from 2013 to 2015. Uu Mh and Uu to donocycline, cycloester erythromycin, azithromycin, clarithromycin, roxithromycin, levofloxacin, sparfloxacin from 2013 to 2015. The drug resistance of sulfomycin and other drugs increased year by year, and the difference was statistically significant (P 0.05). Conclusion Mycoplasma infection mostly occurs in women aged 21 to 30 years, and the incidence of mycoplasma infection is increasing year by year, and drug resistance to various commonly used antimicrobial agents is also increasing year by year. Doxycycline, minocycline and josamycin are the first choice in the treatment of mycoplasma. Appropriate antimicrobial agents can be selected for treatment according to mycoplasma culture and drug sensitivity test.
【作者單位】： 三亞市婦幼保健院檢驗科;三亞市婦幼保健院婦產(chǎn)科;
【基金】：海南省衛(wèi)生廳科技計劃項目(Z2012283)
【分類號】：R446.5;R695

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