本文選題：左卡尼汀 + 維持性血液透析　； 參考：《中國(guó)藥房》2017年11期

【摘要】：目的:探討左卡尼汀對(duì)維持性血液透析患者炎癥因子、氧化應(yīng)激指標(biāo)、心臟功能的影響。方法:選擇我院2014年12月-2016年2月維持性血液透析患者120例,按照隨機(jī)數(shù)字表法分為觀察組和對(duì)照組,各60例。對(duì)照組患者給予維持性血液透析,透析1個(gè)月后皮下注射重組人促紅素注射液3 000 IU,3次/周;觀察組患者在對(duì)照組基礎(chǔ)上于透析結(jié)束后隔日給予注射用左卡尼汀2 g,iv,qod。兩組患者均連續(xù)治療3個(gè)月。觀察兩組患者治療前后炎癥因子[白細(xì)胞介素6(IL-6)、腫瘤壞死因子α(TNF-α)、C反應(yīng)蛋白(CRP)]、氧化應(yīng)激指標(biāo)[丙二醛(MDA)、谷胱甘肽過(guò)氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)]、心臟功能指標(biāo)[心排血量(CO)、左室射血分?jǐn)?shù)(LVEF)、室間隔舒張末期厚度(LVST)]水平,并記錄不良反應(yīng)發(fā)生情況。結(jié)果:治療前,兩組患者炎癥因子、氧化應(yīng)激指標(biāo)和心臟功能指標(biāo)比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,觀察組患者IL-6、TNF-α、CRP和MDA水平較治療前明顯降低,GSH-Px、SOD、CO和LVEF水平明顯升高,且觀察組上述指標(biāo)改善程度明顯優(yōu)于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者治療過(guò)程中均未見(jiàn)明顯不良反應(yīng)。結(jié)論:左卡尼汀能夠有效緩解維持性血液透析患者的微炎癥狀態(tài),保護(hù)心臟功能,且安全性較高。
[Abstract]:Aim: to investigate the effects of levacarnitine on inflammatory factors, oxidative stress and cardiac function in maintenance hemodialysis patients. Methods: 120 patients with maintenance hemodialysis in our hospital from December 2014 to February 2016 were randomly divided into observation group and control group with 60 cases each. The patients in the control group were given maintenance hemodialysis and subcutaneously injected with recombinant human propofol injection 3 000 IUU per week after one month of dialysis, and the patients in the observation group were given levacarnitine 2 g iv qodd on the basis of the control group on the basis of the other day after dialysis. The patients in both groups were treated continuously for 3 months. The levels of inflammatory factor (IL-6), tumor necrosis factor (TNF- 偽) and C-reactive protein (CRP), oxidative stress index (MDA), glutathione peroxidase (GSH-PxN), superoxide dismutase (SOD), cardiac function were observed before and after treatment in both groups. Left ventricular ejection fraction (LVEFV), left ventricular septal end diastolic thickness (LVST), left ventricular ejection fraction (LVEF), left ventricular ejection fraction (LVST). Adverse reactions were recorded. Results: before treatment, there was no significant difference in inflammatory factor, oxidative stress index and cardiac function index between the two groups (P 0.05). After treatment, the levels of IL-6 TNF- 偽 -CRP and MDA in the observation group were significantly lower than those before the treatment. The levels of GSH-PxxSOD- CO and LVEF in the observation group were significantly higher than those in the control group, and the improvement degree of the above indexes in the observation group was significantly better than that in the control group (P 0.05). There were no obvious adverse reactions in both groups. Conclusion: levocarnitine can effectively relieve microinflammation and protect heart function in patients with maintenance hemodialysis.
【作者單位】： 滄州市中心醫(yī)院腎內(nèi)二科;
【分類號(hào)】：R692

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 蔣興亮;劉素蘭;易婷婷;;高同型半胱氨酸血癥患者氧化應(yīng)激指標(biāo)的研究[J];檢驗(yàn)醫(yī)學(xué);2014年02期

2 劉亞利;;氧化應(yīng)激指標(biāo)在早產(chǎn)預(yù)測(cè)及早產(chǎn)治療中的價(jià)值分析[J];甘肅中醫(yī);2010年07期

3 謝芳;殷茵;鄒艷芬;左青;孫麗洲;;妊娠合并甲狀腺功能減退癥患者氧化應(yīng)激指標(biāo)的變化[J];江蘇醫(yī)藥;2013年22期

4 徐新蕾;蔡德亮;;氧化應(yīng)激指標(biāo)與血管性癡呆的關(guān)系研究[J];中國(guó)全科醫(yī)學(xué);2012年33期

5 銀華;高芬芳;安艷;;液相色譜-質(zhì)譜/質(zhì)譜聯(lián)用技術(shù)在氧化應(yīng)激指標(biāo)測(cè)定中的應(yīng)用[J];衛(wèi)生研究;2009年06期

6 梁明;;白內(nèi)障患者房水及血清中氧化應(yīng)激指標(biāo)及血管內(nèi)皮生長(zhǎng)因子的變化[J];海南醫(yī)學(xué)院學(xué)報(bào);2014年03期

7 趙宏鈞;秦琴;余江萍;;阻塞性睡眠呼吸暫停綜合征患者血清微量元素及氧化應(yīng)激指標(biāo)觀察[J];中國(guó)醫(yī)藥導(dǎo)刊;2014年01期

8 郭清軍;施雨;;腦心通膠囊治療血管性癡呆的療效及對(duì)患者氧化應(yīng)激指標(biāo)影響的臨床觀察[J];中國(guó)藥房;2013年03期

9 史玉琴;劉向紅;牛翠嬌;李慧玲;殷志萍;趙文;;赤霉素GA_3對(duì)小鼠不同組織器官氧化應(yīng)激指標(biāo)的影響[J];毒理學(xué)雜志;2011年02期

10 姚瑤;;青光眼患者血清與房水氧化應(yīng)激指標(biāo)的變化研究[J];中國(guó)藥物經(jīng)濟(jì)學(xué);2013年S2期

相關(guān)會(huì)議論文 前2條

1 蔣興亮;劉素蘭;張均;王光華;羅書(shū)久;;高同型半胱氨酸血癥患者氧化應(yīng)激指標(biāo)的研究[A];中華醫(yī)學(xué)會(huì)第七次全國(guó)中青年檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2012年

2 孔衛(wèi)蘭;;2型糖尿病重癥患者氧化應(yīng)激指標(biāo)的測(cè)定及意義[A];中華醫(yī)學(xué)會(huì)第五次全國(guó)重癥醫(yī)學(xué)大會(huì)論文匯編[C];2011年

相關(guān)碩士學(xué)位論文 前2條

1 王龍;腦卒中高危人群氧化應(yīng)激指標(biāo)測(cè)定及頸動(dòng)脈粥樣硬化危險(xiǎn)因素分析[D];遵義醫(yī)學(xué)院;2016年

2 吳茜;Beclin1、LC3、Atg9a mRNA及氧化應(yīng)激指標(biāo)在類風(fēng)濕關(guān)節(jié)炎中的表達(dá)及臨床意義[D];蘭州大學(xué);2016年

，

本文編號(hào)：1862653