發(fā)布時間：2018-05-06 09:09

  本文選題：微量元素 + 前列腺癌�。� 參考：《廣東醫(yī)學(xué)》2017年15期

【摘要】：目的探討前列腺癌(PCa)患者血清中微量元素的水平及其與PCa的病理分級及臨床分期的相關(guān)性。方法回顧性分析PCa、良性前列腺增生癥(BPH)患者以及健康對照組中血清微量元素(Fe、Cu、Cd、Zn、Se、Mn)的水平,分析微量元素與PCa的病理分級、臨床分期的相關(guān)性。結(jié)果 PCa患者血清中Fe、Cu、Cd的含量高于BPH組以及對照組,差異有統(tǒng)計學(xué)意義(P0.05);而PCa組患者血清中Zn、Se水平與BPH組及對照組比較明顯降低,差異有統(tǒng)計學(xué)意義(P0.05);3組患者血清中Mn的水平無明顯改變,差異無統(tǒng)計學(xué)意義(P0.05)。相關(guān)性分析結(jié)果顯示,PCa組患者血清中Fe水平隨著PCa病理分級和臨床分期越高,其血清含量越高,與PCa的病理分級(r=0.928,P=0.000)及臨床分期(r=0.945,P=0.000)呈正相關(guān);血清Zn水平隨著PCa病理分級和臨床分期越高,含量越低,與PCa的病理分級(r=-0.865,P=0.000)及臨床分期(r=-0.936,P=0.000)呈負(fù)相關(guān)。結(jié)論血清微量元素Fe、Cu、Cd的升高以及Zn、Se的降低可能與PCa的發(fā)生相關(guān),其中血清Fe、Zn的含量水平與PCa的分級、分期具有相關(guān)性,對診斷和鑒別PCa具有一定的意義。
[Abstract]:Objective to investigate the level of trace elements in serum of patients with prostate cancer (PCA) and its correlation with pathological grade and clinical stage of PCa. Methods the levels of serum trace elements (FeCuCuCU) in patients with benign prostatic hyperplasia (BPH) and healthy controls were analyzed retrospectively. The correlation between trace elements and pathological grades and clinical stages of PCa was analyzed. Results the serum levels of PCa patients were higher than those of BPH group and control group (P 0.05), but the serum level of PCa group was significantly lower than that of BPH group and control group. There was no significant difference in serum mn level between the three groups (P 0.05) and the difference was not statistically significant (P 0.05). The results of correlation analysis showed that the higher the PCa pathological grade and the clinical stage, the higher the serum Fe level in the PCA group, which was positively correlated with the pathological grade of PCa and the clinical stage (r ~ (0.945) P ~ (0.000), and the serum Fe level was positively correlated with the pathological grade (r ~ (0.928) P ~ (0.000) and the clinical stage (r ~ (0.945) P ~ (0.000). The higher the pathological grade and clinical stage of PCa, the lower the level of serum Zn, which was negatively correlated with the pathological grade of PCa and the clinical stage. Conclusion the increase of serum trace element Feancun CD and the decrease of ZnSe may be related to the occurrence of PCa, and the level of serum Fetir Zn is correlated with the grading and staging of PCa, which has a certain significance for the diagnosis and differential diagnosis of PCa.
【作者單位】： 川北醫(yī)學(xué)院附屬醫(yī)院泌尿外科;
【基金】：南充市應(yīng)用技術(shù)研究與開發(fā)資金項目(編號:16YFZJ0046)
【分類號】：R737.25

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1 胡艷;吳立紅;;慢性腎病綜合癥患者血清微量元素檢測的臨床意義[A];第四屆全國臨床檢驗學(xué)術(shù)會議論文匯編[C];2006年

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本文編號：1851701