發(fā)布時(shí)間：2018-03-13 07:03

  本文選題：終末期腎病　切入點(diǎn)：維持性血液透析　出處：《青海大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:本實(shí)驗(yàn)通過測(cè)定SAA和CRP、TCH、HDL的水平，研究ESRD患者體內(nèi)SAA水平的變化情況，及SAA與CRP、TCH、HDL的相關(guān)性，探討SAA在ESRD患者體內(nèi)微炎癥狀態(tài)、脂質(zhì)代謝紊亂中的作用。 方法：選取青海大學(xué)附屬醫(yī)院血液透析中心進(jìn)行血液透析患者30例，腎病內(nèi)科CKD-5期未進(jìn)行透析的患者30例,選擇體檢者30例為對(duì)照組。分別收集三組各項(xiàng)指標(biāo)值。所采集的數(shù)據(jù)使用SPSS17.0進(jìn)行統(tǒng)計(jì)分析，計(jì)量資料采用x±S表示，不同組別間使用單因素方差分析，兩兩比較采用LSD分析，相關(guān)性分析采用Person分析，檢驗(yàn)水準(zhǔn)為ɑ=0.05。 結(jié)果：1、SAA、CRP和TCH水平在透析組最高，非透析組次之，對(duì)照組的表達(dá)水平最低；而HDL在對(duì)照組表達(dá)水平最高，非透析組次之，透析組最低。2、相關(guān)性分析提示，在對(duì)照組中SAA與CRP呈正相關(guān)，與TCH、HDL無(wú)相關(guān)性。在非透析組和透析組中，SAA均與CRP、TCH呈正相關(guān)，與HDL呈負(fù)相關(guān)。 結(jié)論：1、終末期腎病患者體內(nèi)存在微炎癥反應(yīng)和脂質(zhì)代謝紊亂；血液透析患者體內(nèi)微炎癥反應(yīng)和脂質(zhì)代謝紊亂較非透析患者重。2、終末期腎病，尤其是血液透析患者體內(nèi)SAA表達(dá)水平升高，參與并加重了微炎癥反應(yīng)和脂質(zhì)代謝紊亂，有可能進(jìn)一步提高其心血管疾病發(fā)生率。
[Abstract]:Objective: to study the changes of SAA levels in patients with ESRD and the correlation between SAA and TCHH HDL, and to explore the role of SAA in microinflammation and lipid metabolism disorder in ESRD patients. Methods: thirty hemodialysis patients were selected from hemodialysis center of Qinghai University affiliated hospital, and 30 patients without dialysis in CKD-5 phase of nephropathy department. 30 cases of physical examination were selected as control group. Three groups of index values were collected. The collected data were statistically analyzed by SPSS17.0. The measurement data were expressed by x 鹵S, single factor ANOVA was used among different groups, and LSD analysis was used to compare the data between two groups. Correlation analysis using Person analysis, the test level is 0. 05. Results the levels of HDL and TCH were the highest in dialysis group, followed by non-dialysis group, and the lowest in control group, while the expression level of HDL was the highest in control group, followed by non-dialysis group, and lowest in dialysis group. In the control group, there was a positive correlation between SAA and CRP, but no correlation with CRP, but a positive correlation between SAA and HDL in both non-dialysis group and dialysis group. Conclusion there are microinflammatory reaction and lipid metabolism disorder in patients with end-stage nephropathy, and microinflammatory reaction and lipid metabolism disorder in hemodialysis patients are more serious than those in non-dialysis patients. Especially in hemodialysis patients, the expression of SAA was increased, which involved in microinflammatory reaction and lipid metabolism disorder, which may further increase the incidence of cardiovascular disease.
【學(xué)位授予單位】：青海大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R692.5

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本文編號(hào)：1605294