碳酸司維拉姆輔助治療尿毒癥合并高磷血癥效果觀察
本文選題:尿毒癥 切入點:維持性血液透析 出處:《山東醫(yī)藥》2017年26期 論文類型:期刊論文
【摘要】:目的觀察磷結合劑碳酸司維拉姆治療尿毒癥合并高磷血癥的臨床效果。方法選擇行維持性血液透析的尿毒癥合并高磷血癥患者120例,隨機分為觀察組和對照組各60例。在常規(guī)血液透析治療基礎上,觀察組給予碳酸司維拉姆1.6 g/次,3次/d,對照組給予醋酸鈣1.334 g/次、3次/d。2周后抽取靜脈血,應用自動生化分析儀檢測血清磷、鈣、甲狀旁腺素、堿性磷酸酶、總膽固醇、甘油三酯、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇、尿素氮、肌酐水平。結果治療后兩組血清磷、鈣磷乘積、甲狀旁腺素水平均較治療前下降,觀察組血清磷、鈣磷乘積低于對照組(P均0.05)。觀察組血清低密度脂蛋白膽固醇、尿素氮、肌酐水平較治療前下降(P均0.05),對照組上述指標與治療前比較無統(tǒng)計學差異(P均0.05)。觀察組血清高密度脂蛋白膽固醇水平與治療前比較無統(tǒng)計學差異(P0.05),對照組較治療前明顯下降(P0.05)。結論碳酸司維拉姆可在短期內降低血清磷水平,在降磷的同時還可改善血脂代謝和腎功能。
[Abstract]:Objective to observe the clinical effect of siviram carbonate, a phosphate binding agent, in the treatment of uremia complicated with hyperphosphatemia. Methods 120 patients with uremia complicated with hyperphosphatemia who underwent maintenance hemodialysis were selected. On the basis of routine hemodialysis treatment, the observation group was given sparviram carbonate 1.6 g / time for 3 times / d, and the control group was given calcium acetate 1.334 g / time for 3 / d, and the venous blood was taken after 2 weeks of routine hemodialysis. Serum phosphorus, calcium, parathyroid hormone, alkaline phosphatase, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, urea nitrogen were detected by automatic biochemical analyzer. Results after treatment, the levels of serum phosphorus, calcium and phosphorus, parathyroid hormone in the two groups were decreased, the serum phosphorus and calcium phosphorus product in the observation group were lower than those in the control group (P < 0.05), and the serum low density lipoprotein cholesterol and urea nitrogen in the observation group were lower than those in the control group. The level of creatinine in the control group was lower than that before treatment (P < 0.05), but there was no significant difference in the above indexes between the control group and the control group (P < 0.05). There was no significant difference in serum high density lipoprotein cholesterol level between the observation group and the control group (P 0.05), while in the control group there was no significant difference between the two groups. Conclusion Sveram can decrease serum phosphorus level in a short period of time. It can also improve the metabolism of blood lipids and renal function while reducing phosphorus.
【作者單位】: 山東大學第二醫(yī)院;
【基金】:山東大學第二醫(yī)院青年基金項目(Y2014010009)
【分類號】:R589.4;R692.5
【相似文獻】
相關期刊論文 前10條
1 譚玲;張玉鳳;孫春華;;藥物性高磷血癥[J];藥物不良反應雜志;2006年04期
2 李紅新,周建華;新生兒高磷血癥50例臨床分析[J];現代中西醫(yī)結合雜志;2000年19期
3 劉桂春,楊雪冰,張麗娜,韓素桂;嬰幼兒高磷血癥70例臨床分析[J];中國綜合臨床;2004年09期
4 劉桂春,楊雪冰,張麗娜,韓素桂,苗桂杰;兒童高磷血癥163例臨床分析[J];中國兒童保健雜志;2005年02期
5 潘明明;苗華;;高磷血癥治療新進展[J];國際移植與血液凈化雜志;2006年06期
6 袁發(fā)煥;杜翔;;高磷血癥的危害及其防治[J];中國中西醫(yī)結合腎病雜志;2010年10期
7 程敘揚;蔡美順;崔太根;何蓮;白霞鳳;吳雷云;董捷;王宓;劉婧;朱寧;郭偉亞;喬松;趙慧萍;許戎;左力;王梅;;活性炭聯合大黃類制劑協(xié)助控制慢性腎臟病高磷血癥[J];中國血液凈化;2011年03期
8 張弦;童建菁;;以精神癥狀首發(fā)的急性高磷血癥一例[J];診斷學理論與實踐;2011年03期
9 劉曉琴;李英;施月仙;;慢性腎臟病透析并高磷血癥病人的飲食治療現狀[J];護理研究;2012年07期
10 呂泰虎;白霞;宋立萍;田玉梅;王海燕;;非藥物治療對血液透析患者高磷血癥的療效觀察[J];中國衛(wèi)生產業(yè);2013年09期
相關會議論文 前10條
1 冉敏;;對血透患者并發(fā)高磷血癥臨床癥狀的護理[A];甘肅省中醫(yī)藥學會2010年會員代表大會暨學術年會論文匯編[C];2010年
2 袁發(fā)煥;杜翔;;高磷血癥的危害及其防治[A];第十一屆全國中西醫(yī)結合腎臟病學術會議論文匯編[C];2010年
3 胡錦睿;徐航;王慧商;胡碧t,
本文編號:1586118
本文鏈接:http://sikaile.net/yixuelunwen/mjlw/1586118.html