本文選題：糖尿病腎病　切入點(diǎn)：中性粒細(xì)胞明膠酶相關(guān)載脂蛋白　出處：《中國動脈硬化雜志》2017年11期 　論文類型：期刊論文

【摘要】：目的觀察在早期糖尿病腎病(DN)患者血清中性粒細(xì)胞明膠酶相關(guān)載脂蛋白(NGAL)水平的變化,探討NGAL與致動脈硬化指數(shù)(AIP)的關(guān)系。方法選取尿微量白蛋白/肌酐300 mg/g的糖尿病患者120例為糖尿病組,根據(jù)尿微量白蛋白/肌酐分為正常白蛋白尿組和早期DN組,另選取健康體檢者60例作為對照組。檢測各組血清甘油三酯(TG)、膽固醇(CHOL)、高密度脂蛋白(HDL)、NGAL、超敏C反應(yīng)蛋白(hs-CRP)等,并計(jì)算致動脈硬化指數(shù);分析3組NGAL、hs-CRP、AIP的變化。按照AIP三分位數(shù)將所有研究對象分成低、中、高水平3組,分析其NGAL和hs-CRP的變化。對所有變量進(jìn)行簡單線性相關(guān)和多元線性逐步回歸分析。結(jié)果與對照組比較,正常白蛋白尿組和早期DN組NGAL、hs-CRP、AIP水平明顯升高(P0.001);與正常白蛋白尿組比較,早期DN組NGAL、hs-CRP、AIP水平明顯升高(P0.001)。血清NGAL水平隨AIP上升而明顯上升(P0.001)。AIP與hsCRP、NGAL呈正相關(guān)(r=0.296,0.313,P0.05);NGAL、hs-CRP為AIP的獨(dú)立影響因素。結(jié)論血清NGAL是監(jiān)測糖尿病早期腎損傷的指標(biāo)。NGAL是一個急性時相反應(yīng)蛋白,參與了糖尿病腎病動脈粥樣硬化的發(fā)生發(fā)展。
[Abstract]:Objective to observe the changes of serum neutrophil gelatinase-associated apolipoprotein (apolipoprotein) NGALs in patients with early diabetic nephropathy (DN). To investigate the relationship between NGAL and atherosclerosis index (AIP). Methods 120 diabetic patients with urinary microalbuminuria / creatinine 300 mg/g were selected as diabetic group and divided into normal albuminuria group and early DN group according to urinary microalbumin / creatinine. In addition, 60 healthy persons were selected as control group. Serum triglyceride triglyceride (TGG), cholesterol Choll (CHOLL), high density lipoprotein (HDL) NGALs, hypersensitive C-reactive protein hs-CRP( hs-CRP) were detected and arteriosclerosis index was calculated. The changes of AIP hs-CRP AIP in three groups were analyzed. All the subjects were divided into three groups: low, middle and high levels according to the three-digit number of AIP. The changes of NGAL and hs-CRP were analyzed. A simple linear correlation and multiple linear stepwise regression analysis were carried out on all variables. Results compared with the control group, the levels of NGAL and hs-CRP in normal albuminuria group and early DN group were significantly higher than those in normal albuminuria group and early DN group, and those in normal albuminuria group were significantly higher than those in normal albuminuria group. The serum NGAL level was significantly increased with the increase of AIP in early DN group. There was a positive correlation between serum NGAL level and hsCRPnNGAL. Conclusion Serum NGAL is an acute phase reaction protein for early diabetic renal injury, and it is a positive correlation between NGALHs-CRP and hsCRPnNGAL. Participate in the development of diabetic nephropathy atherosclerosis.
【作者單位】： 河北省人民醫(yī)院檢驗(yàn)科;石家莊市第二醫(yī)院檢驗(yàn)科;
【基金】：河北省醫(yī)學(xué)科學(xué)研究重點(diǎn)課題(20160080)
【分類號】：R587.1;R692.9

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