鹽酸右美托咪定在全身麻醉患者圍拔管期的臨床療效
發(fā)布時間:2019-07-23 16:43
【摘要】:目的:觀察鹽酸右美托咪定用于全身麻醉患者圍拔管期時臨床效果和安全性。方法:選擇全身麻醉術后患者90例,隨即分成3組(n=30):鹽酸右美托咪定組(DEX組)、鹽酸咪達唑侖組(MID組)、對照組(C組)。術前10 min停用所有麻醉藥,同時DEX組首先給予負荷劑量鹽酸右美托咪定1μg/(kg.h),靜脈泵入10 min,繼以0.3μg/(kg.h)的速度持續(xù)泵入至術后20 min;MID組首先60 s內(nèi)靜脈給予鹽酸咪達唑侖0.5 mg/kg,繼以0.04 mg/(kg.h)的速度持續(xù)泵入至術后20 min;C組無干預措施。記錄術后喚醒時間、拔管時間以及拔管時、拔管后10 min、拔管后1 h患者Ramsay評分、平均動脈壓、心率、血氧飽和度及自主呼吸的情況;觀察患者術后寒戰(zhàn)、惡心、嘔吐及不良反應情況。結(jié)果:DEX組不影響喚醒及拔管,MID組有蘇醒延遲(P0.05);與C組相比,DEX組與MID組均可獲得良好鎮(zhèn)靜,Ramsay評分控制在2~4分;DEX組與MID組的心率、血壓平穩(wěn),而MID組對呼吸有明顯抑制(P0.05);DEX組明顯減少術后寒戰(zhàn)、惡心、嘔吐的發(fā)生。結(jié)論:鹽酸右美托咪定應用于全身麻醉圍拔管期,不影響喚醒及拔管時間,能夠抑制異常的血壓升高及心率增快,而且減少躁動、寒戰(zhàn)、術后惡心嘔吐的發(fā)生,從而改善麻醉后的復蘇。
[Abstract]:Objective: to observe the clinical effect and safety of dexmetomide hydrochloric acid in patients with general anesthesia during extubation. Methods: ninety patients after general anesthesia were divided into three groups (n 鈮,
本文編號:2518272
[Abstract]:Objective: to observe the clinical effect and safety of dexmetomide hydrochloric acid in patients with general anesthesia during extubation. Methods: ninety patients after general anesthesia were divided into three groups (n 鈮,
本文編號:2518272
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