【摘要】：目的探討七氟醚丙泊酚復(fù)合麻醉對(duì)于老年胃癌患者術(shù)后早期認(rèn)知功能的影響。方法選取2014年2月至2015年4月期間我院收治的老年胃癌患者80例為研究對(duì)象,按照隨機(jī)數(shù)字法將其分為實(shí)驗(yàn)組和對(duì)照組各40例。實(shí)驗(yàn)組采用七氟醚丙泊酚復(fù)合麻醉,對(duì)照組采用瑞芬太尼丙泊酚復(fù)合麻醉,比較兩組患者的術(shù)后清醒時(shí)間、拔管時(shí)間和術(shù)后MMSE評(píng)分。結(jié)果實(shí)驗(yàn)組術(shù)后清醒時(shí)間為(15.44±3.23)min,明顯快于對(duì)照組(18.73±3.67)min,差異顯著(P0.05),具有統(tǒng)計(jì)學(xué)意義;實(shí)驗(yàn)組拔管時(shí)間為(22.68±3.75)min,明顯快于對(duì)照組(28.65±5.13)min,差異顯著(P0.05),具有統(tǒng)計(jì)學(xué)意義;兩組術(shù)后MMSE評(píng)分均有降低,但實(shí)驗(yàn)組術(shù)后3h MMSE評(píng)分為(19.22±1.88)分,術(shù)后6h MMSE評(píng)分為(21.62±1.57)分,術(shù)后24h MMSE評(píng)分為(27.18±1.13)分,術(shù)后72h MMSE評(píng)分為(24.82±1.77)分,術(shù)后96h MMSE評(píng)分為(28.92±2.52)分;相較于對(duì)照組術(shù)后3h MMSE評(píng)分為(23.71±2.18)分,術(shù)后6h MMSE評(píng)分為(25.65±1.13)分,術(shù)后24h MMSE評(píng)分為(27.57±2.04)分,術(shù)后72h為MMSE評(píng)分(26.92±1.83)分,術(shù)后96h MMSE評(píng)分為(27.26±1.93)分,實(shí)驗(yàn)組明顯降低效果更佳,差異顯著(P0.05),具有統(tǒng)計(jì)學(xué)意義。結(jié)論采用七氟醚丙泊酚復(fù)合麻醉,具有術(shù)后清醒時(shí)間快、拔管時(shí)間快、術(shù)后MMSE評(píng)分低的優(yōu)勢(shì),并且七氟醚會(huì)影響海馬區(qū)LTP形成,其具備麻醉誘導(dǎo)、清醒快等特征,對(duì)老年胃癌患者術(shù)后早期認(rèn)知功能的影響不大,具有臨床推廣價(jià)值。
[Abstract]:Objective to investigate the effect of sevoflurane propofol combined anesthesia on early postoperative cognitive function in elderly patients with gastric cancer. Methods from February 2014 to April 2015, 80 elderly patients with gastric cancer were randomly divided into two groups: experimental group (n = 40) and control group (n = 40). Sevoflurane propofol combined anesthesia was used in the experimental group and remifentanil propofol combined anesthesia was used in the control group. The postoperative awake time, extubation time and postoperative MMSE score were compared between the two groups. Results the awake time of the experimental group (15.44 鹵3.23) min, was significantly faster than that of the control group (18.73 鹵3.67) min, (P0.05). The extubation time in the experimental group (22.68 鹵3.75) min, was significantly faster than that in the control group (28.65 鹵5.13) min, (P0.05). The MMSE scores were decreased in both groups, but the MMSE scores were (19.22 鹵1.88), (21.62 鹵1.57) and (27.18 鹵1.13) respectively at 3 h, 6 h and 24 h after operation in the experimental group, the MMSE score and the 24 h post-operation MMSE score, respectively. The MMSE score at 72 h after operation was (24.82 鹵1.77), and the MMSE score at 96 h after operation was (28.92 鹵2.52). Compared with the control group, the MMSE score at 3 h after operation was (23.71 鹵2.18), the MMSE score at 6 h after operation was (25.65 鹵1.13), the MMSE score at 24 h after operation was (27.57 鹵2.04), and the MMSE score at 72 h after operation was (26.92 鹵1.83). The MMSE score at 96 h after operation was (27.26 鹵1.93) in the experimental group, and the effect of the experimental group was better than that in the control group (P0.05). Conclusion combined anesthesia with sevoflurane and propofol has the advantages of rapid waking time, extubation time and low MMSE score after operation. Sevoflurane can affect the formation of LTP in hippocampus, and it has the characteristics of anesthesia induction and rapid awakening. It has little effect on early postoperative cognitive function in elderly patients with gastric cancer, and has clinical value.
【作者單位】： 內(nèi)蒙古赤峰市第二醫(yī)院;
【分類號(hào)】：R614;R735.2
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本文編號(hào)：2468811