【摘要】：目的比較丙泊酚或依托咪酯麻醉后對幼兒近、遠期認知功能的影響。方法 100例1~3歲擬行擇期腹腔鏡下疝修補術(shù)患兒,隨機分為丙泊酚麻醉組(A組)、依托咪酯麻醉組(B組)各50例;50例同年齡段健康幼兒作對照組(C組)。A、B組麻醉誘導(dǎo)分別給予丙泊酚1~3 mg·kg-1、依托咪酯0.1~0.4mg·kg-1,在此基礎(chǔ)上均給予芬太尼(1~2)×10-3mg·kg-1、羅庫溴銨0.6~1.2 mg·kg-1,均于手術(shù)開始前給予芬太尼2×10-3mg·kg-1進行麻醉維持。A、B組均于術(shù)前1 d、術(shù)后3 d和3個月用貝莉嬰幼兒認知量表-Ⅲ(BSID-Ⅲ)按月齡進行相應(yīng)年齡段的認知功能評估,C組同期進行,比較各組3個時期認知功能的改變。結(jié)果與術(shù)前1 d比較,A、B組術(shù)后3 d評分均下降(P0.05),術(shù)后認知功能障礙患兒分別為10例(20.0%)、9例(18.0%),術(shù)后3個月認知功能評分及術(shù)后認知功能障礙發(fā)生率差異無統(tǒng)計學(xué)意義(P0.05);A、B組比較,術(shù)后3 d、術(shù)后3個月認知評分及術(shù)后認知功能障礙發(fā)生率差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論丙泊酚或依托咪酯麻醉后可引起1~3歲患兒術(shù)后早期出現(xiàn)不同程度的可逆的認知功能下降,在術(shù)后3個月內(nèi)自行恢復(fù)。
[Abstract]:Objective to compare the effects of propofol or etomidate on children's near and long-term cognitive function. Methods 100 children (1 ~ 3 years old) undergoing laparoscopic herniorrhaphy were randomly divided into propofol anesthesia group (group A) and etomidate anesthesia group (group B). 50 healthy children of the same age were taken as control group (group C). Propofol 1 + 3 mg kg-1, etomidate 0.1~0.4mg kg-1, was given to anaesthesia induction in group A and group B respectively. On this basis, fentanyl (1? 2) 脳 10-3mg kg-1, was given respectively. Rocuronium 0.6 mg kg-1, was administered with fentanyl 2 脳 10-3mg kg-1 before operation. Three days and three months after operation, the cognitive function of infants and children was evaluated with BSID- 鈪，

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