電針內關穴對心臟瓣膜置換術患者氧化應激的影響
發(fā)布時間:2019-01-21 12:44
【摘要】:目的:觀察電針內關穴對體外循環(huán)下行瓣膜置換術患者的心肌保護作用。方法:擬行心臟瓣膜置換術的風濕性心臟病患者50例,根據(jù)美國麻醉醫(yī)師協(xié)會(ASA)分級為Ⅱ~Ⅲ級,紐約心臟病協(xié)會心功能分級Ⅱ~Ⅲ級,隨機分為觀察組和對照組,每組25例。兩組患者均采用相同的麻醉及體外循環(huán)灌注技術。觀察組于術前30min電針刺激雙側內關穴直至手術結束。分別于主動脈阻斷前(T1),主動脈開放后15min(T2)、30min(T3)、6h(T4)、24h(T5)5個時點采集中心靜脈血,檢測血清丙二醛(MDA)、超氧化物歧化酶(SOD)、心肌鈣蛋白I(cTnI)濃度,并記錄心臟復跳及術后血管活性藥物使用總量等情況。結果:與主動脈阻斷前比較,兩組患者在主動脈開放后各時間點MDA、cTnI明顯升高(均P0.05),SOD明顯下降(P0.05);與對照組比較,在T3~T5時間點,觀察組血清MDA、cTnI明顯低于對照組(均P0.05),SOD則高于對照組(P0.05);血管活性藥物使用量明顯減少(P0.05)。結論:電針內關穴可減輕氧化應激損傷,對缺血再灌注心肌具有保護作用。
[Abstract]:Objective: to observe the myocardial protective effect of electroacupuncture at Neiguan point on patients undergoing valve replacement under cardiopulmonary bypass. Methods: fifty patients with rheumatic heart disease undergoing cardiac valve replacement were randomly divided into observation group and control group according to the (ASA) grade of the American Association of Anesthesiologists and the cardiac function grade 鈪,
本文編號:2412674
[Abstract]:Objective: to observe the myocardial protective effect of electroacupuncture at Neiguan point on patients undergoing valve replacement under cardiopulmonary bypass. Methods: fifty patients with rheumatic heart disease undergoing cardiac valve replacement were randomly divided into observation group and control group according to the (ASA) grade of the American Association of Anesthesiologists and the cardiac function grade 鈪,
本文編號:2412674
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