【摘要】：目的觀察母兔球海綿體括約肌反射(BCR)的波形,并分析其在急性骶髓缺血后的變化特點(diǎn)。方法18只母兔隨機(jī)分為3組,預(yù)實(shí)驗(yàn)組(n=6)用于確定最佳刺激強(qiáng)度及排除麻醉和手術(shù)對(duì)BCR的影響;對(duì)照組手術(shù)分離腰動(dòng)脈而不結(jié)扎腰動(dòng)脈,實(shí)驗(yàn)組(n=6)結(jié)扎左腎動(dòng)脈和動(dòng)脈分叉間5條腰動(dòng)脈建立骶髓缺血損傷動(dòng)物模型,腰動(dòng)脈結(jié)扎后連續(xù)記錄BCR波形2 h,觀察BCR波在急性骶髓缺血后的變化特點(diǎn),分別記錄腰動(dòng)脈結(jié)扎后2 h和2 d的BCR波形,2 d后取骶髓HE染色鏡下觀察。結(jié)果對(duì)照組和實(shí)驗(yàn)組手術(shù)前均記錄到穩(wěn)定的BCR波,潛伏期(11.5±1.5)ms,波幅(261.2±275.3)μV;實(shí)驗(yàn)組骶髓缺血后可見波幅即刻開始降低、潛伏期即刻開始延長(zhǎng),經(jīng)(0.67±0.40)min后波幅完全消失,實(shí)驗(yàn)組手術(shù)后2 d波幅與基線的比值是0,低于對(duì)照組(99.2%±3.8%)(P0.05)。結(jié)論母兔可以記錄到穩(wěn)定的BCR波形,急性骶髓缺血后BCR波幅降低、潛伏期延長(zhǎng)。
[Abstract]:Objective to observe the waveform of sphincter reflex (BCR) in female rabbits and to analyze its changes after acute sacral spinal cord ischemia. Methods Eighteen female rabbits were randomly divided into 3 groups. The experimental group (NN6) was used to determine the optimal stimulation intensity and to exclude the effect of anesthesia and operation on BCR. In the control group, the lumbar artery was separated without ligation of the lumbar artery. In the experimental group (NN6), 5 lumbar arteries were ligated between the left renal artery and the artery bifurcation to establish the animal model of sacral spinal cord ischemia injury. The BCR waveform was recorded continuously for 2 h after ligation of the lumbar artery. The changes of BCR wave after acute sacral spinal cord ischemia were observed. The BCR waveforms were recorded at 2 hours and 2 days after ligation of lumbar artery respectively. The sacral spinal cord was stained with HE after 2 days. Results the stable BCR wave was recorded in the control group and the experimental group before operation, the latency was (11.5 鹵1.5) ms, and the amplitude was (261.2 鹵275.3) 渭 V. After sacral spinal cord ischemia, the amplitude of sacral spinal cord in the experimental group began to decrease and the incubation period was prolonged immediately. After (0.67 鹵0.40) min, the amplitude of the wave disappeared completely. The ratio of amplitude to baseline was 0 on the 2nd day after operation in the experimental group. Lower than the control group (99.2% 鹵3.8%) (P0.05). Conclusion stable BCR waveforms can be recorded in female rabbits. The amplitude of BCR is decreased and the latency is prolonged after acute sacral spinal cord ischemia.
【作者單位】： 臨沂市第三人民醫(yī)院;
【基金】：山東醫(yī)藥衛(wèi)生科技發(fā)展計(jì)劃面上項(xiàng)目(2015WS0375)
【分類號(hào)】：R741

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