【摘要】：1.目的 探索鈹針治療末梢神經(jīng)張力性疼痛的機(jī)理,評價鈹針療法的安全性、有效性,為鈹針療法的臨床應(yīng)用及推廣提供實驗依據(jù)。2.方法2.1造模 用Wistar大鼠80只,隨機(jī)分為5組,每組16只。A組：不做任何處理；B組：將大鼠雙側(cè)隱神經(jīng)做適當(dāng)游離,不進(jìn)行卡壓處理；C組：以內(nèi)徑0.5mm的硅膠管卡壓大鼠雙側(cè)隱神經(jīng)；D組：以內(nèi)徑0.4mm的硅膠管卡壓大鼠雙側(cè)隱神經(jīng)；E組：以內(nèi)徑0.3mm的硅膠管卡壓大鼠雙側(cè)隱神經(jīng)。各組術(shù)后1個月每組隨機(jī)抽取8只大鼠進(jìn)行隱神經(jīng)大體形態(tài)觀察和電生理學(xué)檢測。 2.2鈹針治療 1個月造模成功后,對A組大鼠不做任何處理,對B、C、D、E組每組余下8只大鼠進(jìn)行鈹針治療,每周一次,治療三周。治療結(jié)束后,對每組大鼠進(jìn)行大體形態(tài)觀察和電生理學(xué)檢測。 3.結(jié)果 經(jīng)鈹針治療后,B、C、D組的神經(jīng)傳導(dǎo)速度較治療前均有所好轉(zhuǎn)(P0.05),說明鈹針對B、C、D組治療有效；A組未進(jìn)行任何處理,前后相差不明顯(P0.05)；E組治療后仍未引出動作電位,說明E組神經(jīng)損傷嚴(yán)重,鈹針治療無效。鈹針治療后,A、B兩組比較,P0.05,差異無統(tǒng)計學(xué)意義,說明A、B兩組神經(jīng)傳導(dǎo)速度相差不明顯；B、C兩組比較,P0.05,差異有統(tǒng)計學(xué)意義,說明雖然B、C兩組神經(jīng)傳導(dǎo)速度較鈹針治療前有所好轉(zhuǎn),但C組神經(jīng)傳導(dǎo)速度小于B組；C、D兩組比較,P0.05,差異有統(tǒng)計學(xué)意義,說明雖然C、D兩組神經(jīng)傳導(dǎo)速度較鈹針治療前有所好轉(zhuǎn),但D組神經(jīng)傳導(dǎo)速度小于C組。該實驗結(jié)果顯示鈹針治療皮神經(jīng)卡壓造成的神經(jīng)損傷有一定效果,但隨著卡壓硅膠管內(nèi)徑的縮小,壓力增加,神經(jīng)損傷程度加重,鈹針的療效會相應(yīng)降低,當(dāng)神經(jīng)損傷嚴(yán)重,造成不可逆性損傷時,鈹針治療無效。 4.結(jié)論 鈹針治療末梢神經(jīng)張力性疼痛,具有不需要麻醉、創(chuàng)傷小、痛苦小、術(shù)中對神經(jīng)周圍組織的損傷少、術(shù)后神經(jīng)周圍形成的疤痕小、定位準(zhǔn)確、松解較為充分、癥狀改善明顯等特點。是一種安全、簡便、療效肯定、易于推廣的新療法,它的出現(xiàn)為臨床常見的疼痛性疾病的治療開辟了新的思路,適合在基層廣泛推廣應(yīng)用。
[Abstract]:1. Objective to explore the mechanism of beryllium acupuncture in the treatment of peripheral nerve tensional pain, to evaluate the safety and efficacy of beryllium needle therapy, and to provide experimental evidence for clinical application and popularization of beryllium needle therapy. Methods 80 Wistar rats were randomly divided into 5 groups, 16 rats in each group. Group A: no treatment, group B: the bilateral saphenous nerve was dissociated properly, and the bilateral saphenous nerve was not compressed. In group C, bilateral saphenous nerve was compressed with silica gel tube with inner diameter of 0.5mm, group D with silica gel tube with inner diameter of 0.4mm, group E with silica gel tube with inner diameter of 0.3mm to compress bilateral saphenous nerve of rats. One month after operation, 8 rats in each group were randomly selected to observe the saphenous nerve gross morphology and electrophysiology. 2.2 the rats in group A were treated with beryllium needle once a week for three weeks, and the remaining 8 rats in group A were treated with beryllium needle once a week. After the treatment, the gross morphology and electrophysiology of each group were observed. 3. Results after treatment with beryllium needle, the nerve conduction velocity in group B was better than that in group B (P0.05), which indicated that beryllium was effective in group B CfU D. Group A did not have any treatment, the difference was not significant (P0.05); E group after treatment still did not elicit action potential, indicating that group E nerve injury is serious, beryllium needle treatment is not effective. After beryllium needle treatment, there was no significant difference in nerve conduction velocity between the two groups (P 0.05), indicating that there was no significant difference in nerve conduction velocity between the two groups. The difference between group B and C was statistically significant (P 0.05), which indicated that although the nerve conduction velocity of group B was better than that of group B before beryllium needle therapy, the nerve conduction velocity of group C was lower than that of group B; The difference between group C and D was statistically significant (P 0.05), which indicated that although the nerve conduction velocity of group C was better than that of group C before beryllium needle therapy, the nerve conduction velocity of group D was lower than that of group C. The experimental results show that beryllium needle has a certain effect on nerve injury caused by cutaneous nerve entrapment. However, with the reduction of internal diameter of compressed silica gel tube, the increase of pressure and the severity of nerve injury, the curative effect of beryllium needle will be reduced accordingly, when the nerve injury is serious, When irreversibility injury is caused, beryllium needle therapy is ineffective. 4. Conclusion beryllium needle has no need of anesthesia, less trauma, less pain, less injury to peripheral nerve tissue, small scar around nerve after operation, accurate orientation and sufficient release. Symptoms improved obviously and so on. It is a safe, simple, effective and easy to popularize new therapy. It opens up a new idea for the treatment of common clinical pain diseases, and is suitable for wide application at the grass-roots level.
【學(xué)位授予單位】：北京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R245

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