老年人實(shí)施輕比重蛛網(wǎng)膜下腔麻醉藥物的劑量和安全性研究
發(fā)布時(shí)間:2018-12-17 05:51
【摘要】:目的探索60歲以上患者實(shí)施輕比重蛛網(wǎng)膜下腔阻滯的可行性及安全劑量范圍。方法選取2006年9月—2012年9月于北京大學(xué)人民醫(yī)院診治,在輕比重蛛網(wǎng)膜下腔麻醉下行股骨粗隆間骨折閉合復(fù)位防旋股骨近端髓內(nèi)釘(PFNA)內(nèi)固定術(shù)的60歲以上患者146例,根據(jù)患者年齡將其分為60~79歲組(Ⅰ組,74例)和≥80歲組(Ⅱ組,72例)。兩組患者均于L2~3或L3~4間隙行單次蛛網(wǎng)膜下腔穿刺或一點(diǎn)法腰硬聯(lián)合阻滯,穿刺成功后,緩慢注入0.2%輕比重布比卡因。根據(jù)電子記錄麻醉單檢索并獲取患者蛛網(wǎng)膜下腔麻醉前,麻醉后5、10、20、30、60 min及出室前的血壓,布比卡因用量,麻醉平面,麻醉期間的輸液量,是否采用旁正中入路,術(shù)中出血量,手術(shù)時(shí)間,根據(jù)電子病歷系統(tǒng)檢索并獲取術(shù)后至出院期間所有新發(fā)的并發(fā)癥。并采用Logistic回歸分析影響蛛網(wǎng)膜下腔麻醉后低血壓發(fā)生的可能危險(xiǎn)因素。結(jié)果兩組患者輸液量、實(shí)施髂淺筋膜阻滯、采用旁正中入路、使用縮血管藥物、術(shù)后并發(fā)癥、麻醉平面、手術(shù)時(shí)間、術(shù)中出血量和術(shù)后住院時(shí)間比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者布比卡因劑量比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者不同時(shí)間平均動(dòng)脈壓比較,差異無統(tǒng)計(jì)學(xué)意義(F交互=0.325,F組間=0.708,F時(shí)間=14.202;P交互=0.688,P組間=0.402,P時(shí)間0.001)。兩組患者蛛網(wǎng)膜下腔麻醉后5、10、20、30、60min時(shí)平均動(dòng)脈壓均較蛛網(wǎng)膜下腔麻醉前下降(P0.05)。Logistic回歸分析結(jié)果顯示,蛛網(wǎng)膜下腔麻醉前收縮壓和麻醉平面是蛛網(wǎng)膜下腔麻醉后血壓下降的危險(xiǎn)因素(P0.05)。結(jié)論對(duì)80歲及以上的患者實(shí)施輕比重蛛網(wǎng)膜下腔麻醉時(shí),推薦劑量8~10 mg;60~79歲患者,推薦劑量9~12 mg。老年患者蛛網(wǎng)膜下腔麻醉后血壓下降發(fā)生率高,需積極地進(jìn)行縮血管藥物治療。
[Abstract]:Objective to explore the feasibility and safe dose range of light specific gravity subarachnoid block in patients over 60 years old. Methods from September 2006 to September 2012, 146 patients over 60 years old who were diagnosed and treated in the people's Hospital of Peking University under light specific gravity subarachnoid anesthesia for closed reduction and (PFNA) internal fixation of femoral intertrochanteric fracture were selected. According to the age of the patients, they were divided into two groups: group 鈪,
本文編號(hào):2383761
[Abstract]:Objective to explore the feasibility and safe dose range of light specific gravity subarachnoid block in patients over 60 years old. Methods from September 2006 to September 2012, 146 patients over 60 years old who were diagnosed and treated in the people's Hospital of Peking University under light specific gravity subarachnoid anesthesia for closed reduction and (PFNA) internal fixation of femoral intertrochanteric fracture were selected. According to the age of the patients, they were divided into two groups: group 鈪,
本文編號(hào):2383761
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