【摘要】：目的:評價(jià)右美托咪定對肢體缺血再灌注誘發(fā)肺損傷的影響。方法:擇期行擇期行下肢手術(shù)患者40例,性別不限,年齡40~65歲,體質(zhì)量50~85 kg,ASA分級Ⅰ或Ⅱ級。采用隨機(jī)數(shù)字表法,將其分為2組(n=20):對照組(C組)和右美托咪定組(D組)。麻醉誘導(dǎo)后氣管插管,機(jī)械通氣,采用靜吸復(fù)合麻醉。麻醉誘導(dǎo)后,D組靜脈輸注右美托咪定1μg·kg-1(加入100 ml生理鹽水),C組給予生理鹽水,于止血帶充氣前滴注完畢。于麻醉誘導(dǎo)前(T1)、止血帶充氣(T2)、60 min(T3)、90 min(T4)時(shí),止血帶放氣后5 min(T5)、30 min(T6)時(shí)采集橈動脈血樣,行血?dú)夥治?計(jì)算氧合指數(shù)和呼吸指數(shù)。測定血漿白介素6(IL-6)、丙二醛(MDA)及細(xì)胞間黏附分子(ICAM-1)的濃度。結(jié)果:與C組相比,D組T2~5時(shí)RI升高(P0.05),而OI差異無統(tǒng)計(jì)學(xué)意義(P0.05);D組T2~6時(shí)血漿IL-6、MDA及ICAM-1的濃度降低(P0.05)。結(jié)論:右美托咪定可減輕肢體缺血再灌注誘發(fā)的肺損傷,其機(jī)制與抑制炎性反應(yīng)有關(guān)。
[Abstract]:Aim: to evaluate the effect of dexmetomidine on limb ischemia reperfusion induced lung injury. Methods: a total of 40 patients with lower extremity surgery were enrolled in this study. The age was 4065 years old and the body mass was 50 ~ 85 kg,ASA grade 鈪，

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