【摘要】：目的探討不同性別對腹部手術(shù)全身麻醉患者單次靜脈注射丙泊酚的藥動學影響。方法選擇2012年5月-2013年5月來該院就診并實施腹部全身麻醉手術(shù)患者36例,按照不同性別將其分為男性組和女性組,每組各18例。兩組患者均采用靜吸復合麻醉,分別于注射丙泊酚后的1、2、3、4、5、10、15、30、45、60、90、120、150、180、240、360和720 min時抽取3 ml靜脈血,血漿丙泊酚濃度使用高效液相色譜-熒光檢測法測定,并以上述時間點為時間軸繪制血藥濃度-時間曲線,分別計算兩組患者藥代動力學參數(shù)。結(jié)果兩組患者血藥濃度均快速下降,但女性組腹部手術(shù)全身麻醉患者在10 min以內(nèi)的各個時間點的血藥濃度均顯著低于男性組,差異有統(tǒng)計學意義(P0.05)。10 min以后的各個時間點兩組患者的血藥濃度差異無統(tǒng)計學意義;女性組中央式分布容積(Vc)和清除率(CL)顯著高于男性組,差異有統(tǒng)計學意義(P0.05),兩組患者的其他藥代動力學參數(shù)組間比較差異無統(tǒng)計學意義(P0.05)。結(jié)論對全麻患者靜脈注射丙泊酚后,女性患者在各個時間點采集的血藥濃度均低于男性患者,中央式分布容積(Vc)和清除率(CL)女性患者顯著高于男性,表明不同性別對腹部手術(shù)全麻病人單次靜脈注射丙泊酚的藥代動力學有明顯的影響。
[Abstract]:Objective to investigate the pharmacokinetics of propofol by single intravenous injection of propofol in patients undergoing general anesthesia during abdominal surgery. Methods from May 2012 to May 2013, 36 patients with abdominal general anesthesia were selected and divided into male group and female group, 18 cases in each group. Patients in both groups were anesthetized by intravenous inhalation. Plasma propofol concentrations were determined by high performance liquid chromatography (HPLC) and fluorescence detection (HPLC) after injection of propofol. Three ml venous blood samples were drawn from the patients with propofol at the time of injection of propofol at 10153030, 6090120150180240360 and 720 min, respectively, and the plasma propofol concentration was determined by high performance liquid chromatography (HPLC) and fluorescence detection. The pharmacokinetic parameters of the two groups were calculated by drawing the blood concentration-time curve on the time axis. Results the blood drug concentration of the two groups decreased rapidly, but the blood drug concentration of the female group was significantly lower than that of the male group at every time point within 10 min after abdominal operation. There was no significant difference in blood drug concentration between the two groups after 10 min (P0.05). The central distributed volume (Vc) and clearance (CL) of female group were significantly higher than that of male group. The difference was statistically significant (P0.05). There was no significant difference in other pharmacokinetic parameters between the two groups (P0.05). Conclusion after intravenous injection of propofol, the serum concentration of propofol in female patients was significantly lower than that in male patients at all time points, and the central distributed volume (Vc) and clearance rate (CL) in female patients were significantly higher than those in male patients. The results showed that different genders had significant effect on the pharmacokinetics of propofol in patients with general anesthesia during abdominal surgery.
【作者單位】： 遼寧醫(yī)學院附屬第三醫(yī)院手術(shù)室;遼寧醫(yī)學院附屬第三醫(yī)院麻醉科;
【分類號】：R614

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