【摘要】：目的探討電針刺激對糖尿病患者術(shù)后認(rèn)知功能及血清炎性因子的影響。方法選擇行胃腸道惡性腫瘤根治術(shù)的糖尿病患者90例,隨機均分為電針刺激組(E組)和對照組(C組),另外選取45例非糖尿病患者為正常組(N組),記錄三組患者麻醉前1d、術(shù)后3、7d簡易智力狀態(tài)評分(MMSE評分)和術(shù)后拔管及送離蘇醒室的時間,于電針刺激前(T1)、手術(shù)開始后2h(T2)、手術(shù)結(jié)束后1h(T3)、術(shù)后24h(T4)抽血測患者血糖水平及血清炎性因子IL-6、IL-1β的水平,術(shù)后3、7d術(shù)后認(rèn)知功能障礙(POCD)發(fā)生率。結(jié)果與C組比較,T2~T4時E組血糖、血清IL-6、IL-1β水平明顯降低(P0.05)。與N組比較,T2~T4時E組、C組血糖、血清IL-6、IL-1β水平明顯升高(P0.05)。與T1時比較,T2、T3時三組患者血糖、血清IL-6、IL-1β,T4時E組、C組血清IL-6、IL-1β水平明顯升高(P0.05)。與T2時比較,T3時三組血糖、IL-6、IL-1β水平明顯升高(P0.05),T4時三組血糖、血清IL-6、IL-1β水平明顯降低(P0.05)。與T3時比較,T4時三組血糖、血清IL-6、IL-1β水平明顯降低(P0.05)。術(shù)后3、7dE組和C組MMSE評分明顯低于術(shù)前,術(shù)后3dE組,術(shù)后3、7dN組MMSE評分明顯高于,POCD發(fā)生率明顯低于C組(P0.05)。結(jié)論電針刺激可以降低糖尿病患者術(shù)后認(rèn)知功能障礙的發(fā)生,并降低血清IL-6、IL-1β水平。
[Abstract]:Objective to investigate the effect of electroacupuncture stimulation on postoperative cognitive function and serum inflammatory factors in diabetic patients. Methods 90 patients with diabetes underwent radical resection of gastrointestinal malignant tumor were selected. They were randomly divided into two groups: electroacupuncture group (group E) and control group (group C). Another 45 cases of non-diabetic patients were selected as normal group (group N). The scores of simple mental state (MMSE) and extubation were recorded 1 day before anesthesia, 3 days after anesthesia and 3 days after operation. The time to be sent away from the waking room, Blood glucose levels and serum inflammatory factor IL-6,IL-1 尾 levels were measured before electroacupuncture stimulation (T1), 2 hours after operation (T2), 1 hour after operation (T3), 24 hours after operation (T4), and the incidence of (POCD) in patients with cognitive impairment at 3 and 7 days after operation. Results compared with group C, blood glucose and serum IL-6,IL-1 尾 levels in group E were significantly lower than those in group C (P 0.05). Compared with group N, blood glucose and serum IL-6,IL-1 尾 levels in group E were significantly higher than those in group B (P 0.05). The level of serum IL-6,IL-1 尾 in group E was significantly higher than that in group C at T _ 1 and T _ 2 / T _ 3 (P 0.05), and the level of serum IL-6,IL-1 尾 in group E was significantly higher than that in group E at T _ (2) T _ (3) (P < 0.05). Compared with T2, the levels of IL-6 and IL-1 尾 in the three groups were significantly higher than those in the control group (P0.05), and the serum IL-6,IL-1 尾 level was significantly lower in the three groups than in the T4 group (P0.05). Compared with T 3, the blood glucose and serum IL-6,IL-1 尾 levels in the three groups were significantly lower than those at T 4 (P 0.05). The MMSE scores in group E and group C were significantly lower than those in group C at 3 ~ 7 days after operation. The MMSE score in group N was significantly higher than that in group C at 3 ~ 7 days after operation (P0.05). Conclusion electroacupuncture stimulation can reduce the incidence of cognitive dysfunction and the level of serum IL-6,IL-1 尾 in diabetic patients.
【作者單位】： 南昌大學(xué)第二附屬醫(yī)院麻醉科;
【基金】：江西省衛(wèi)生廳中醫(yī)處課題項目(2013A192)
【分類號】：R614

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