不同年齡患者意識消失時丙泊酚的用量
[Abstract]:Objective to observe the changes of propofol dosage and Narcotrend index (NI) in patients with anaesthesia induced consciousness loss, and to explore the correlation between age and propofol dosage and NI. Methods 140 patients aged 370 years with elective surgery were studied. According to the age, the patients were divided into 7 groups: group G _ 1, group G _ 2, group G _ 3, group C _ 3, group C _ 4, group G _ 4, group C _ 5, group G _ 5, age 60 (group G _ 6) and group G _ 7 (group G _ 7). Each group included 10 male and female patients with BMI within normal range. The dosage of propofol, the time of consciousness disappearance and the changes of HRNI were recorded before and after intravenous infusion of propofol 20mg kg-1 h-1. Results the dosage of propofol in G1 group was significantly higher than that in G2~G7 group (P0.01) and G2G4 group was significantly higher than that in G6 G7 group (P0.05). The dosage of propofol was negatively correlated with age when consciousness disappeared (r = -0.566, P 0.001). The time of loss of consciousness decreases with age. Compared with those before propofol infusion, MAP and NI decreased significantly in the seven groups when consciousness disappeared (P0.05). NI in G1 group was significantly higher than that in G2~G6 group (P0.05). There was no significant correlation between age and NI (r = 0.082, P = 0.289). Conclusion the dosage of propofol and NI are different in patients with different ages when the consciousness of anesthesia induction disappears. The dosage and NI of propofol in young patients are higher than those in other ages.
【作者單位】: 寧夏醫(yī)科大學(xué);寧夏醫(yī)科大學(xué)總醫(yī)院麻醉科;
【基金】:寧夏自然科學(xué)基金(編號:NZ1237)
【分類號】:R614
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