本文選題：麻醉 + 吸入　； 參考：《福建醫(yī)科大學》2014年碩士論文

【摘要】：目的研究低流量吸入麻醉對異氟醚藥效學的影響，分析低流量吸入麻醉時聽覺誘發(fā)電位指數與呼氣末濃度的相關性，評價AAI監(jiān)測低流量異氟醚麻醉深度的可行性。方法30例ASA I～II的病人低流量異氟醚吸入麻醉。誘導前、誘導后5min、高流量洗入期1min、3min、5min、7min、9min、12min，，低流量維持期呼氣末異氟醚濃度0.8MAC、1.0MAC、1.3MAC時以及以及關閉異氟醚揮發(fā)罐后1、3、5、7、9、12、15、20、30min分別記錄BP、HR、AAI、呼氣末異氟醚濃度（ETI）。結果以AAI為藥效學指標所得到的異氟醚藥效學參數：ke0為0.276±0.116min-1，EC501.183±0.216%v/v，γ4.268±1.675。高流量洗入平衡期， AAI顯著下降與吸入前相比各時間點的水平均有顯著性差異（P0.05），AAI與ETI，MAP，HR相關系數分別為0.862、0.345、0.398。在低流量維持期AAI在各肺泡呼氣末濃度之間有顯著性差異（P0.05）,AAI與呼氣末異氟醚濃度，MAP，HR相關系數分別為0.854、0.454、0.395。結論低流量異氟醚吸入麻醉起效快，較平穩(wěn)；麻醉過程中AAI與異氟醚呼氣末濃度有很好的相關性，可作為監(jiān)測異氟醚低流量吸入麻醉深度的指標。但AAI與MAP，HR無明顯相關性，提示AAI作為監(jiān)測應激反應的指標需要進一步的研究。
[Abstract]:Objective to study the effect of low flow inhalation anesthesia on the pharmacodynamics of isoflurane, to analyze the correlation between auditory evoked potential index and end expiratory concentration during low flow inhalation anesthesia, and to evaluate the feasibility of monitoring the depth of low flow isoflurane anesthesia by AAI. Methods 30 patients with ASA I~II were anesthetized with low flow isoflurane. Before induction, 5 min after induction, 1 min / 3 min / 5 min / 7 min / 9 min / 12 min, 0.8 MAC / 1.0 MAC / 1.3 MAC during low flow maintenance period, and 1 min / 3 C / min after closing the volatilization tank of isoflurane, BPU HRAAI, end expiratory isoflurane concentration and ETI were recorded respectively at 1 min, 3 min, 5 min after induction and 1 min after closing the volatile pot of isoflurane, respectively, and the end expiratory isoflurane concentration (ETI) was measured. Results the pharmacodynamic parameters of isoflurane obtained by AAI were 0.276 鹵0.116min-1EC501.183 鹵0.216v / v, 緯 4.268 鹵1.675. During the equilibrium period of high flow washing, the levels of AAI decreased significantly compared with those before inhalation. The correlation coefficients of P0.05AAI and ETI MAPA HR were 0.862 鹵0.345and 0.398respectively. There were significant differences in AAI between different alveolar end-expiratory concentrations during low flow maintenance period. The correlation coefficients between AAI and end-expiratory isoflurane concentrations were 0.854V 0.454V 0.395. Conclusion low flow isoflurane inhalation anesthesia is effective and stable, and AAI has a good correlation with end-expiratory concentration of isoflurane during anesthesia, which can be used as an index to monitor the depth of isoflurane inhalation anesthesia. However, there was no significant correlation between AAI and MAPHR, suggesting that AAI as an indicator of stress response should be further studied.
【學位授予單位】：福建醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R614

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