本文選題：急性腦出血 + β-內(nèi)啡肽��； 參考：《山東醫(yī)藥》2017年29期

【摘要】：目的探討急性腦出血(ICH)患者血漿和腦脊液中β-內(nèi)啡肽、促性腺激素釋放激素(GnRH)水平變化及其對(duì)腦損傷程度和預(yù)后的影響。方法 89例ICH患者為病例組,按照斯堪的納維亞卒中量表(SSS)評(píng)分將其分為輕型ICH組(SSS評(píng)分0~15分,n=41)、中型ICH組(SSS評(píng)分16~30分,n=28)、重型ICH組(SSS評(píng)分31~45分,n=20例),按照格拉斯哥預(yù)后量表(GOS)評(píng)分將其分為預(yù)后良好組(GOS評(píng)分4~5分,n=63)、預(yù)后不良組(GOS評(píng)分1~3分,n=26)。采用放射免疫法對(duì)患者入院后1、3、7、14、30 d血漿和腦脊液中β-內(nèi)啡肽、GnRH水平進(jìn)行檢測(cè)。并于同期選取30例無神經(jīng)系統(tǒng)疾病且行腰穿麻醉術(shù)的患者為對(duì)照組。結(jié)果隨著入院時(shí)間延長(zhǎng),輕型、中型、重型ICH患者血漿、腦脊液中β-內(nèi)啡肽、GnRH水平均呈逐漸下降趨勢(shì)(P均0.05)。病例組入院后1、3、7、14 d血漿、腦脊液β-內(nèi)啡肽、GnRH水平均高于對(duì)照組(P均0.05),輕型、中型、重型ICH組間兩兩比較,P均0.05。入院30 d時(shí),中型、重型ICH組血漿、腦脊液β-內(nèi)啡肽、GnRH水平高于輕型ICH組、對(duì)照組,重型ICH組血漿、腦脊液β-內(nèi)啡肽、GnRH水平高于中型ICH組(P均0.05)。預(yù)后良好組入院1、3、7、14、30 d血漿、腦脊液β-內(nèi)啡肽、GnRH水平均低于預(yù)后不良組(P均0.05)。結(jié)論 ICH患者血漿和腦脊液中β-內(nèi)啡肽、GnRH水平升高,其水平升高可致腦損傷程度加重,預(yù)后變差。
[Abstract]:Objective to investigate the changes of 尾 -endorphin and gonadotropin releasing hormone (GnRH) in plasma and cerebrospinal fluid (CSF) of patients with acute cerebral hemorrhage (ICH) and their effects on the degree of brain injury and prognosis. Methods Eighty-nine patients with ICH were enrolled in the study. According to the Scandinavian Stroke scale (SSS) score, it was divided into mild ICH group (0 ~ 15), moderate ICH group (16 ~ 30%) and severe ICH group (31 ~ 45 cases). They were classified as prognosis according to Glasgow prognosis scale (Glasgow prognosis scale) score. In the good group, the GOS score ranged from 4 to 5, and the GOS score was 1 ~ 3 in the poor prognosis group. The levels of 尾 -endorphin GnRH in plasma and cerebrospinal fluid (CSF) were measured by radioimmunoassay on 30 days after admission. At the same time, 30 patients without nervous system disease and undergoing lumbar anesthesia were selected as control group. Results the levels of 尾 -endorphin GnRH in plasma and cerebrospinal fluid (CSF) of patients with mild, moderate and severe ICH showed a decreasing trend with the prolongation of admission time (P < 0.05). The levels of 尾 -endorphin GnRH in cerebrospinal fluid (CSF) were significantly higher in the case group than those in the control group (P < 0.05) on the 14th day after admission, and were significantly higher than those in the control group (P < 0.05), and were significantly higher in the mild, moderate and severe ICH groups than in the other two groups (P < 0.05). 30 days after admission, the plasma and cerebrospinal fluid 尾 -endorphin GnRH levels in moderate and severe ICH group were higher than those in mild ICH group. The plasma and cerebrospinal fluid 尾 -endorphin GnRH levels in control group and severe ICH group were higher than those in moderate ICH group (P < 0.05). The levels of 尾 -endorphin GnRH in cerebrospinal fluid (CSF) were lower than those in patients with poor prognosis (P < 0.05). Conclusion the level of 尾 -endorphin GnRH in plasma and cerebrospinal fluid of patients with ICH is increased, which can lead to severe brain injury and poor prognosis.
【作者單位】： 青海紅十字醫(yī)院;
【基金】：青海省衛(wèi)生計(jì)生指導(dǎo)性基金資助項(xiàng)目(2015KRB02964)
【分類號(hào)】：R743.34

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

1 王廣;羅超;彭形;蔣光明;談俊;吳海波;蔣光元;肖剛;吳琳;吳斌;;腦出血與蛛網(wǎng)膜下腔出血后β-內(nèi)啡肽和促性腺激素釋放激素水平變化研究[J];中國(guó)全科醫(yī)學(xué);2017年06期

2 王小蓉;杜曉渝;陳婭;張瓊桂;何曉英;李小剛;;S-100B檢測(cè)對(duì)急性腦出血患者臨床預(yù)后的評(píng)估價(jià)值研究[J];中國(guó)醫(yī)藥導(dǎo)報(bào);2013年15期

3 李娟;唐朝亮;康芳;黃祥;柴小青;;帕瑞昔布鈉用于顱腦手術(shù)患者的鎮(zhèn)痛效果及對(duì)血漿β-內(nèi)啡肽的影響[J];臨床麻醉學(xué)雜志;2012年06期

4 肖杰文;李學(xué)偉;朱礪;;促性腺激素釋放激素受體的結(jié)構(gòu)及其生物學(xué)功能[J];生理科學(xué)進(jìn)展;2008年02期

5 ;各類腦血管疾病診斷要點(diǎn)[J];中華神經(jīng)科雜志;1996年06期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 戚勝;董立煥;成杰;王云龍;劉萍萍;劉艷豐;王衛(wèi)亮;張愛麗;;腦卒中后急性應(yīng)激障礙患者發(fā)生便秘的影響因素[J];中國(guó)健康心理學(xué)雜志;2017年09期

2 李新杰;喬欽增;王靜;左慧;;健康教育照護(hù)者對(duì)腦卒中后抑郁患者療效的影響[J];預(yù)防醫(yī)學(xué)情報(bào)雜志;2017年08期

3 韓林;高e，

本文編號(hào)：1873691