本文選題：維庫溴銨 + 神經肌肉阻滯��； 參考：《臨床麻醉學雜志》2015年04期

【摘要】：目的探討ORM1 A113G基因多態(tài)性對女性患者維庫溴銨肌松效應的影響。方法選擇擇期全麻下乳腺包塊切除術貴州漢族女性患者107例,年齡18~65歲。術前采集外周靜脈血5ml,使用天根血液基因組DNA提取試劑盒抽取DNA。采用3730XL DNA測序儀直接測序對ORM1A113G進行基因分型。麻醉誘導期間給予維庫溴銨0.1mg/kg,用TOF-Watch加速度儀進行肌松監(jiān)測。觀察起效時間、時效、體內作用時間、恢復指數(shù)、TOF恢復到25%的時間。結果根據(jù)基因型將患者分為野生型純合子組(AA組,n=71)、突變型雜合子組(AG組,n=35)和突變型純合子組(GG組,n=1)。將AG組和GG組兩種基因型合并為變異組。與AA組比較,變異組的時效和TOF恢復到25%時間均明顯延長(P0.05);起效時間、恢復指數(shù)和體內作用時間差異無統(tǒng)計學意義。結論ORM1 A113G基因多態(tài)性可在一定程度上影響貴州漢族女性患者維庫溴銨的肌松效應。
[Abstract]:Objective to investigate the effect of polymorphism of ORM1 A 113G gene on muscle relaxation of vecuronium bromide in female patients. Methods 107 female patients, aged 1865 years, underwent breast mass resection under elective general anesthesia in Guizhou Han nationality. The peripheral venous blood was collected 5 ml before operation and the genomic DNA extraction kit was used to extract DNA. The genotyping of ORM1A113G was carried out by direct sequencing with 3730XL DNA sequencer. Vecuronium bromide was given 0.1 mg / kg during anesthesia induction, and muscle relaxation was monitored by TOF-Watch accelerometer. The response time, time of action, time of action in vivo and recovery index of TOF were observed to be 25%. Results the patients were divided into wild type homozygote group (AA group), mutant heterozygote group (AG group) and mutant homozygote group (GG group). AG and GG genotypes were combined into variant group. Compared with AA group, the time of time and TOF recovery to 25% in the mutant group were significantly prolonged (P 0.05), but there was no significant difference in the onset time, recovery index and in vivo action time. Conclusion the polymorphism of ORM1 A113G gene may affect the muscle relaxation effect of vecuronium in Guizhou Han women.
【作者單位】： 福建省立醫(yī)院麻醉科;上海市浦東醫(yī)院麻醉科;貴陽醫(yī)學院麻醉學系;
【基金】：上海市衛(wèi)計委基金(20134272)
【分類號】：R614

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