本文選題：型糖尿病 + 老年人�。� 參考：《中西醫(yī)結(jié)合心腦血管病雜志》2016年22期

【摘要】：目的探討右美托咪定預(yù)給藥對(duì)行非體外循環(huán)下冠脈搭橋術(shù)老年2型糖尿病病人圍術(shù)期興奮性氨基酸及血清S-100β和神經(jīng)元烯醇化酶(NSE)含量的影響,為圍術(shù)期老年病人使用右美托咪定提供依據(jù)。方法選擇預(yù)行非體外循環(huán)下冠脈搭橋老年2型糖尿病病人100例,心功能分級(jí)Ⅱ級(jí)~Ⅲ級(jí),左室射血分?jǐn)?shù)(LVEF)35%,ASA分級(jí)Ⅱ級(jí)~Ⅲ級(jí),按數(shù)字隨機(jī)表法將病人分為對(duì)照組、右美托咪定組,右美托咪定組在術(shù)前持續(xù)泵入右美托咪定1μg/(kg·h),至病人入手術(shù)間麻醉常規(guī)誘導(dǎo)后改為0.5μg/(kg·h),術(shù)畢1 h后停藥,分別檢測(cè)兩組切皮前(h0)術(shù)畢(h1)、術(shù)后12 h(h2)、24 h(h3)、48 h(h4)、72 h(h5)病人頸Qg靜脈血內(nèi)興奮性氨基酸(EAA)及血清S-100β和神經(jīng)元烯醇化酶含量。結(jié)果右美托咪定組病人術(shù)后興奮性氨基酸與血清S-100β和神經(jīng)元烯醇化酶含量與對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論右美托咪定預(yù)給藥對(duì)行冠脈搭橋術(shù)老年2型糖尿病病人圍術(shù)期神經(jīng)系統(tǒng)功能可能有保護(hù)作用。
[Abstract]:Objective to investigate the effects of dexmetomidine preadministration on serum S-100 尾 and neuron-enolase (NSE) levels in elderly patients with type 2 diabetes mellitus undergoing off-pump coronary artery bypass grafting. To provide evidence for perioperative elderly patients to use dexmetomidine. Methods 100 elderly patients with type 2 diabetes mellitus undergoing off-pump coronary artery bypass grafting were selected. Cardiac function grade 鈪，

本文編號(hào)：1779426