本文選題：前列地爾　切入點(diǎn)：心臟瓣膜假體置換術(shù)　出處：《重慶醫(yī)學(xué)》2015年16期

【摘要】：目的評(píng)價(jià)前列腺素E1(PGE1)對(duì)心臟瓣膜置換術(shù)患者心肌細(xì)胞核轉(zhuǎn)錄因子κB(NF-κB)活性和血漿腫瘤壞死因子α(TNF-α)水平的影響。方法擇期行體外循環(huán)下心臟瓣膜置換術(shù)的患者40例,年齡32~67歲,體質(zhì)量指數(shù)17~28kg/m2,美國(guó)麻醉師協(xié)會(huì)(ASA)分級(jí)Ⅱ或Ⅲ級(jí),紐約心臟病協(xié)會(huì)(NYHA)分級(jí)Ⅱ或Ⅲ級(jí)。采用隨機(jī)數(shù)字表法,將患者分為2組(n=20):對(duì)照組(C組)和PGE1組(P組)。麻醉誘導(dǎo)后P組靜脈輸注PGE1 20ng·kg-1·min-1,至手術(shù)結(jié)束,C組給予等容量生理鹽水。于體外循環(huán)前(T0,基礎(chǔ)值)、體外循環(huán)開始后30min(T1)、體外循環(huán)結(jié)束時(shí)(T2)、體外循環(huán)結(jié)束后12h(T3)、體外循環(huán)結(jié)束后24h(T4)抽取動(dòng)脈血,檢測(cè)血漿TNF-α水平;于T0和T2時(shí)取右心耳組織,觀察組織病理學(xué)變化,并用蛋白免疫印跡法(Western blot)檢測(cè)NF-κB活性。結(jié)果與C組比較,P組T1~T4時(shí)血漿TNF-α水平下降(P0.05),T2時(shí)心肌病理學(xué)損傷明顯減輕,心肌細(xì)胞NF-κB活性下降(P0.05)。結(jié)論 PGE1可減輕心臟瓣膜置換術(shù)患者心肌損傷,其機(jī)制與抑制心肌細(xì)胞NF-κB活性,減少血漿TNF-α水平有關(guān)。
[Abstract]:Objective to evaluate the effects of prostaglandin E 1 (PGE 1) on myocardial nuclear transcription factor 魏 B (NF 魏 B) activity and plasma tumor necrosis factor 偽 TNF- 偽 (TNF- 偽) levels in patients undergoing cardiac valve replacement. Methods 40 patients, aged 32 to 67 years, underwent elective cardiac valve replacement under cardiopulmonary bypass (CPB). The body mass index (BMI) was 17 ~ 28kg / m ~ (2), the American anesthesiologist's Association (ASA) was graded 鈪，

本文編號(hào)：1699040