本文選題：麻醉　切入點：血液流變學　出處：《中國輸血雜志》2016年04期 　論文類型：期刊論文

【摘要】：目的探討戊巴比妥鈉靜脈麻醉對比格犬血液流變學特性和靜脈血氣的影響。方法比格犬30只,分別在麻醉前清醒狀態(tài)和麻醉后15 min,于前肢內(nèi)測皮下頭靜脈采血4 m L/只做血液流變學參數(shù)測定,取200μL/只立即做血氣分析測定。結(jié)果戊巴比妥鈉靜脈麻醉前后比格犬外周靜脈血中Hb(g/L)為16.31±1.07 vs 13.13±0.94,Hct(%)為49.99±3.27 vs 40.25±2.88(P0.01);不同切應力下的全血粘度(m Pa·s)分別為10(s-1)∶7.11±0.88vs 5.03±1.39,50(s-1)∶4.47±0.42 vs 3.50±0.53,150(s-1)∶3.73±0.36 vs 2.92±0.33(P0.01);紅細胞聚集指數(shù)為47.72±2.20 vs 43.18±3.23,聚集時間(s)為0.272±0.034 vs 0.430±0.124(P0.01);血乳酸(Lac)濃度(mmol·L-1)為1.46±0.56 vs 1.03±0.44(P0.01),靜脈血氧分壓(PvO2)(mm Hg)為48.69±8.45 vs 55.39±8.16,靜脈血氧飽和度(SvO2)(%)為84.56±7.00 vs 90.53±3.46(P0.01)。結(jié)論戊巴比妥鈉靜脈麻醉可能在一定程度上改善實驗動物的血流灌注,提示在失血性休克復蘇血流灌注指標評價時應考慮戊巴比妥鈉麻醉的影響。
[Abstract]:Objective to investigate the effects of pentobarbital sodium intravenous anesthesia on hemorheological characteristics and venous blood gas in Beagle dogs. Before anesthesia and 15 min after anesthesia, blood was collected from subcutaneous cephalic vein in the forelimb for 4 mL, and hemorheology parameters were measured only. Results before and after intravenous anesthesia with pentobarbital sodium, the blood volume of the peripheral veins of Beagle dogs was 16.31 鹵1.07 vs 13.13 鹵0.94Hctl): 49.99 鹵3.27 vs 40.25 鹵2.88P0.01; and the whole blood viscosity under different shear stress was 100.11 鹵0.88 vs 5.03 鹵1.350s-1W 4.47 鹵0.42 vs 3.50 鹵0.53Hctl vs 2.92 鹵0.33P0.01respectively; the RBC viscosity was 7.11 鹵0.88 vs 5.03 鹵1.350s-1W 4.47 鹵0.42 vs 3.50 鹵0.53Hctl vs 3.73 鹵0.36 vs 2.92 鹵0.33P0.01P 0.01; the whole blood viscosity of pentobarbital sodium was 7.11 鹵0.88 vs 5.03 鹵1.350s-1BW 4.47 鹵0.42 vs 3.50 鹵0.53Hctl respectively. The set index was 47.72 鹵2.20 vs 43.18 鹵3.23, the aggregation time was 0.272 鹵0.034 vs 0.430 鹵0.124 P0.01g; the concentration of Lactol lactate was 1.46 鹵0.56 vs 1.03 鹵0.44p 0.01g; the partial pressure of oxygen in venous blood was 48.69 鹵8.45 vs 55.39 鹵8.16; the oxygen saturation of venous blood was 84.56 鹵7.00 vs 90.53 鹵3.46P0.01.Conclusion intravenous anesthesia with sodium barbiturium may be of some extent. Improve blood flow in laboratory animals, It is suggested that the effect of pentobarbital sodium anesthesia should be considered in the evaluation of blood perfusion index of hemorrhagic shock resuscitation.
【作者單位】： 軍事醫(yī)學科學院野戰(zhàn)輸血研究所;
【基金】：北京市科委首都市民健康培育項目(Z121100005312014)
【分類號】：R614

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