本文選題：右美托咪定　切入點：利多卡因　出處：《動物醫(yī)學(xué)進展》2017年09期 　論文類型：期刊論文

【摘要】：為了減小異氟烷麻醉的不良反應(yīng),獲得良好的麻醉效果,探討了鹽酸右美托咪定和利多卡因復(fù)合靜脈輸注對異氟烷麻醉效果的影響。將12只臨床健康的小型成年犬隨機分為單一異氟烷(13mL/L)維持麻醉組(ISO)和右美托咪定(每小時2μg/kg靜脈輸注)-利多卡因(每小時50μg/kg靜脈輸注)-異氟烷(7.5mL/L)復(fù)合維持麻醉組(LDI)。兩組犬均采用相同的麻醉前處理并輔助機械通氣,麻醉維持時間1h,并監(jiān)測和記錄各項麻醉相關(guān)指標。結(jié)果顯示,與ISO組相比,復(fù)合麻醉組犬只能更快地進入麻醉穩(wěn)定期(P0.01),鎮(zhèn)靜、鎮(zhèn)痛和肌松效果更好(P0.05),恢復(fù)蘇醒的時間也更短(P0.01);期間動物心率明顯降低(P0.01),但血壓和血氣離子濃度變化相對穩(wěn)定。此外,心臟出現(xiàn)的代償性擴張(P0.05)和血液動力學(xué)變化并未明顯影響心臟的收縮和射血功能,均在臨床可接受范圍內(nèi)。結(jié)果表明,鹽酸右美托咪定和利多卡因復(fù)合用藥可減少異氟烷的使用濃度,提供穩(wěn)定的麻醉效果,動物的蘇醒質(zhì)量更佳,可以用于臨床麻醉。
[Abstract]:In order to reduce the adverse reaction of isoflurane anesthesia and obtain good anaesthesia effect, To investigate the effect of dexmetidine hydrochloride and lidocaine on the anesthetic effect of isoflurane, 12 healthy adult dogs were randomly divided into single isoflurane (13ml / L) maintenance anesthesia group (ISO) and dexmetomidine (per dose). Lidocaine (50 渭 g / kg / h) was administered intravenously for 2 渭 g / kg / h to maintain LDI in the anesthesia group. The dogs in both groups were treated with the same anaesthesia preconditioning and assisted mechanical ventilation. The duration of anesthesia was 1 h, and various anaesthesis-related indexes were monitored and recorded. The results showed that the dogs in the compound anesthesia group were able to enter the stable stage of anesthesia more quickly than the ISO group. The effects of analgesia and muscle relaxation were better than that of P0.05, and the recovery time was also shorter. During the period, the heart rate of the animals decreased significantly, but the changes of blood pressure and blood gas ion concentration were relatively stable. The compensatory dilatation of the heart (P0.05) and hemodynamic changes did not significantly affect the systolic and ejection function of the heart, and were within the range of clinical acceptability. The combination of dexmetidine hydrochloride and lidocaine can reduce the concentration of isoflurane and provide a stable anesthetic effect. The recovery quality of animals is better and can be used in clinical anesthesia.
【作者單位】： 西南民族大學(xué)生命科學(xué)與技術(shù)學(xué)院;
【基金】：四川省科技培訓(xùn)項目(2016KZ0007) 四川省教改項目(20140108)
【分類號】：S859.791
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本文編號：1572675