本文關(guān)鍵詞： 頸動(dòng)脈粥樣硬化斑塊 內(nèi)膜損傷 拉曼實(shí)驗(yàn) 壓力實(shí)驗(yàn)　出處：《中國臨床解剖學(xué)雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的探討不同頸椎推拿手法對(duì)食蟹猴輕度頸動(dòng)脈粥樣硬化(CAS)模型穩(wěn)定性的影響。方法將18只食蟹猴建立輕度CAS模型,并以高脂飼料喂養(yǎng)8周,用彩超證實(shí)其造模成功。再將18只食蟹猴隨機(jī)分為3組(每組6只),分別是:頸椎旋轉(zhuǎn)組、推橋弓組和模型對(duì)照組。分別對(duì)頸椎旋轉(zhuǎn)組和推橋弓組的食蟹猴進(jìn)行相應(yīng)的手法干預(yù),共干預(yù)30 d,模型對(duì)照組不做特殊干預(yù)。最后將動(dòng)物麻醉后處死,取頸總動(dòng)脈分別進(jìn)行HE染色、拉曼實(shí)驗(yàn)和壓力實(shí)驗(yàn)。結(jié)果 HE染色可見頸總動(dòng)脈血管內(nèi)壁損傷嚴(yán)重,有斑塊形成。拉曼試驗(yàn)中,3組均有明顯的1450及1660脂質(zhì)特征峰,但三組特征峰的相對(duì)強(qiáng)度差異無顯著性意義(P0.05)。壓力實(shí)驗(yàn)中,三組中食蟹猴頸動(dòng)脈斑塊破裂壓力檢測(cè)結(jié)果顯示無顯著性意義(P0.05)。結(jié)論在食蟹猴輕度CAS病變中,短期內(nèi)施用頸椎旋轉(zhuǎn)手法和推橋弓手法并不會(huì)改變斑塊的穩(wěn)定性。
[Abstract]:Objective to investigate the effects of cervical massage on neck atherosclerosis mild cynomolgus monkeys (CAS) affect the stability of the model. Methods: 18 cynomolgus monkeys establish mild CAS model, and fed with high fat diet for 8 weeks, with ultrasound confirmed successful modeling. Then 18 cynomolgus monkeys were randomly divided into 3 groups (each group 6), namely: cervical rotation group, Qiaogong group and control group respectively. The corresponding manual intervention on cervical rotation group and cynomolgus monkeys Qiaogong group, a total of 30 d intervention, the model control group did not intervene. The animal were sacrificed after anesthesia, the external carotid artery were stained with HE, Raman and pressure analysis. The results of HE staining showed carotid artery wall damage, plaque. Raman test, the 3 groups were 1450 and 1660 lipid obvious characteristic peaks, but there was no significant difference between the three groups of relative intensity of characteristic peak pressure (P0.05). In the three groups, there was no significant difference in the detection results of carotid plaque rupture pressure between the two groups (P0.05). Conclusion in the mild CAS disease of cynomolgus monkeys, cervical spine rotation and push bridging maneuver in a short time will not change the stability of the plaques.

【作者單位】： 西南醫(yī)科大學(xué)附屬中醫(yī)醫(yī)院;南方醫(yī)科大學(xué)中醫(yī)藥學(xué)院;廣州中醫(yī)藥大學(xué);
【基金】：四川省教育廳科研項(xiàng)目(17ZB0472) 瀘州市科技局科技計(jì)劃項(xiàng)目(2016-176-13) 西南醫(yī)科大學(xué)-西南醫(yī)科大學(xué)附屬中醫(yī)醫(yī)院聯(lián)合專項(xiàng)項(xiàng)目(2016-4-4)
【分類號(hào)】：R244.1

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