本文關(guān)鍵詞：地佐辛在小兒闌尾切除術(shù)麻醉中的安全性　出處：《吉林醫(yī)學(xué)》2016年09期 　論文類型：期刊論文

  更多相關(guān)文章： 地佐辛 小兒闌尾切除術(shù) 麻醉安全性 丙泊酚聯(lián)合瑞芬太尼全憑靜脈麻醉

【摘要】：目的:評價術(shù)中地佐辛在小兒闌尾切除術(shù)麻醉中的安全性。方法:選擇擬行小兒闌尾切除術(shù)患兒60例。隨機(jī)分為地佐辛組(DZX組)和生理鹽水組(NS組),每組30例。兩組術(shù)中輸注瑞芬太尼0.2~0.3μg(kg·min)和丙泊酚4~8 mg/(kg·1)維持麻醉。手術(shù)開始切皮時,DZX組與NS組分別持續(xù)輸注0.1 mg/kg地佐辛和生理鹽水。記錄自主呼吸恢復(fù)、呼喚睜眼、拔管時間;蘇醒后5 min、30 min、12 h、24 h、48 h疼痛(visual analogue scales,VAS)評分;誘導(dǎo)前(T0),誘導(dǎo)后(T1)、插管后(T2)、術(shù)中(T3)、拔管時(T4)、拔管后10 min(T5)平均動脈壓(MAP)和心率(HR);術(shù)中知曉、蘇醒時躁動、靜脈滴注曲馬多、術(shù)后嘔心/嘔吐、過度鎮(zhèn)靜和呼吸抑制發(fā)生情況。結(jié)果:DZX組與NS組自主呼吸恢復(fù)、呼喚睜眼及拔管時間無統(tǒng)計學(xué)意義(P0.05);DZX組蘇醒后5 min、30 min和4 h VAS評分低于NS組(P0.05);在T4、T5時點比較,DZX組MAP和HR低于NS組(P0.05);DZX組蘇醒時躁動、疼痛(VAS評分≥3)、術(shù)后使用曲馬多發(fā)生率低于NS組(P0.05)。結(jié)論:術(shù)中輸注地佐辛改善丙泊酚聯(lián)合瑞芬太尼全憑靜脈麻醉下小兒闌尾切除術(shù)患兒術(shù)后的痛覺過敏。
[Abstract]:Objective: to evaluate the safety of intraoperative dizosin during appendectomy in children. Methods: 60 children undergoing appendectomy were randomly divided into DZX group (n = 60) and saline group (n = 60). Group NS). 30 patients in each group were given remifentanil (0.2 渭 g / kg 路min) and propofol (48 mg/(kg 路min) intraoperatively. DZX group and NS group were continuously infused with dizosin and normal saline for 0.1 mg/kg respectively. The time of spontaneous respiration recovery, eye opening and extubation were recorded. Visual analogue scales scale (VASs) score was obtained 5 min after waking up at 30 min and 12 h at 24 h and 48 h after recovery. The mean arterial pressure (MAPP) and heart rate (HRV) were observed in T0, T1, T2, T3, T4 and T5 during extubation and 10 min after extubation. Intraoperative knowledge, restlessness during recovery, tramadol intravenous drip, postoperative nausea / vomiting, excessive sedation and respiratory inhibition. There was no significant difference in the time of eye opening and extubation (P 0.05). The VAS scores in DZX group were lower than those in NS group at 30 min and 4 h after waking up 5 minutes after recovery (P 0.05). The MAP and HR of DZX group were lower than that of NS group at T4 / T5 time point. In DZX group, the patients were restless and the pain score was 鈮，

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