2013-2014年寧波農(nóng)村地區(qū)手足口病病原學流行特征分析
發(fā)布時間：2019-04-26 13:28
【摘要】：目的分析2013-2014年寧波農(nóng)村地區(qū)手足口病(HFMD)病原學流行特征及規(guī)律,為手足口病的預防控制提供病原學依據(jù)。方法選取2013年1月-2014年12月寧波農(nóng)村地區(qū)臨床診斷為HFMD的患兒334例為研究對象,采用實時熒光定量PCR方法對研究對象標本進行腸道病毒通用型(EV)、腸道病毒71型(EV71)、柯薩奇病毒A組16型(CoxA16)核酸檢測,并運用SPSS19.0進行描述性流行病學分析。結果采集到的334例HFMD病例生物學標本,陽性檢出率為73.05%,其中EV71、CoxA16和其他EV比例分別占17.62%、17.62%和64.75%;兩年間HFMD病原構成差異有統(tǒng)計學意義(P0.05),EV71在春夏季感染率高,CoxA16在夏秋季感染率高,其他EV四季普遍易感,差異有統(tǒng)計學意義(P0.05);不同性別、職業(yè)及5歲人群的HFMD病原構成基本相同,感染各型病原的風險差異無統(tǒng)計學意義;重癥病例EV71感染率高于普通病例,EV71感染者重癥病例發(fā)生率最高,差異均有統(tǒng)計學意義(P0.05)。結論該地區(qū)不同特征人群EV71、CoxA16及其他EV的感染率主要受總體優(yōu)勢病原影響。EV71、CoxA16及其他EV的感染流行季節(jié)有差異,且病原類型與患兒臨床病情輕重程度有關,在HFMD流行季節(jié)開展病原監(jiān)測有助于指導臨床治療,避免不良預后的發(fā)生。
[Abstract]:Objective to analyze the epidemic characteristics and regularity of hand, foot and mouth disease (HFMD) in rural areas of Ningbo from 2013 to 2014, so as to provide the etiological basis for the prevention and control of hand, foot and mouth disease (HFMD). Methods A total of 334 children diagnosed as HFMD from January 2013 to December 2014 in rural areas of Ningbo were selected as subjects. Real-time fluorescence quantitative PCR was used to detect enterovirus type (EV), enterovirus 71 (EV71). Coxsackievirus A group 16 (CoxA16) nucleic acid was detected and SPSS19.0 was used for descriptive epidemiological analysis. Results the positive rate of HFMD was 73.05%, among which the proportion of EV71,CoxA16 and other EV was 17.62%, 17.62% and 64.75%, respectively. There was significant difference in the pathogen composition of HFMD between the two years (P0.05), the infection rate of EV71 in spring and summer was high, the infection rate of CoxA16 in summer and autumn was high, the other four seasons of EV were susceptible to infection, the difference was statistically significant (P0.05); There was no significant difference in the risk of infection of HFMD between different sex, occupation and 5-year-old population, but there was no significant difference in the risk of infection among different types of pathogens. The infection rate of EV71 in severe cases was higher than that in common cases, and the incidence of severe cases with EV71 infection was the highest, the difference was statistically significant (P0.05). Conclusion the infection rates of EV71,CoxA16 and other EV in different characteristic population in this area are mainly affected by the overall dominant pathogen. The epidemic seasons of EV 71, CoxA16 and other EV are different, and the pathogen type is related to the severity of the clinical condition of the children. The pathogen monitoring during the epidemic season of HFMD is helpful to guide clinical treatment and avoid the occurrence of bad prognosis.
【作者單位】： 浙江大學公共衛(wèi)生學院;寧波市鄞州區(qū)疾病預防控制中心;寧波市鄞州區(qū)邱隘中心衛(wèi)生院;浙江中醫(yī)藥大學流行病學與衛(wèi)生統(tǒng)計學教研室;
【基金】：浙江省醫(yī)藥衛(wèi)生科技基金資助項目(2009A190) 寧波市鄞州區(qū)科技局第二批科技計劃基金資助項目[(2012)90號]
【分類號】：R725.1;R181.3
，
本文編號：2466105
[Abstract]:Objective to analyze the epidemic characteristics and regularity of hand, foot and mouth disease (HFMD) in rural areas of Ningbo from 2013 to 2014, so as to provide the etiological basis for the prevention and control of hand, foot and mouth disease (HFMD). Methods A total of 334 children diagnosed as HFMD from January 2013 to December 2014 in rural areas of Ningbo were selected as subjects. Real-time fluorescence quantitative PCR was used to detect enterovirus type (EV), enterovirus 71 (EV71). Coxsackievirus A group 16 (CoxA16) nucleic acid was detected and SPSS19.0 was used for descriptive epidemiological analysis. Results the positive rate of HFMD was 73.05%, among which the proportion of EV71,CoxA16 and other EV was 17.62%, 17.62% and 64.75%, respectively. There was significant difference in the pathogen composition of HFMD between the two years (P0.05), the infection rate of EV71 in spring and summer was high, the infection rate of CoxA16 in summer and autumn was high, the other four seasons of EV were susceptible to infection, the difference was statistically significant (P0.05); There was no significant difference in the risk of infection of HFMD between different sex, occupation and 5-year-old population, but there was no significant difference in the risk of infection among different types of pathogens. The infection rate of EV71 in severe cases was higher than that in common cases, and the incidence of severe cases with EV71 infection was the highest, the difference was statistically significant (P0.05). Conclusion the infection rates of EV71,CoxA16 and other EV in different characteristic population in this area are mainly affected by the overall dominant pathogen. The epidemic seasons of EV 71, CoxA16 and other EV are different, and the pathogen type is related to the severity of the clinical condition of the children. The pathogen monitoring during the epidemic season of HFMD is helpful to guide clinical treatment and avoid the occurrence of bad prognosis.
【作者單位】： 浙江大學公共衛(wèi)生學院;寧波市鄞州區(qū)疾病預防控制中心;寧波市鄞州區(qū)邱隘中心衛(wèi)生院;浙江中醫(yī)藥大學流行病學與衛(wèi)生統(tǒng)計學教研室;
【基金】：浙江省醫(yī)藥衛(wèi)生科技基金資助項目(2009A190) 寧波市鄞州區(qū)科技局第二批科技計劃基金資助項目[(2012)90號]
【分類號】：R725.1;R181.3
，
本文編號：2466105
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