烏魯木齊市2007-2010年度流感病毒病原學(xué)監(jiān)測分析
發(fā)布時間：2019-02-19 13:20
【摘要】：目的：探討烏魯木齊市流感流行規(guī)律,便于做好流行性感冒的預(yù)防與控制工作。同時為烏魯木齊市流感病毒的變異預(yù)防控制研究奠定基礎(chǔ)。方法：通過中國流感中心流感監(jiān)測系統(tǒng),對烏魯木齊市2007-2010年的流感進(jìn)行病原學(xué)監(jiān)測。結(jié)果：通過對烏魯木齊市2007～2010年流感監(jiān)測資料進(jìn)行分析發(fā)現(xiàn)：1、在2007/2008監(jiān)測年度,共采集流感樣病例標(biāo)本127份,其中檢出流感病毒B型(Victoria系) 1株,B型(Yamagata) 6株,檢出率為5.51%。在2008/2009監(jiān)測年度,共采集流感樣病例標(biāo)本203份,其中檢出流感病毒全部為B型(Victoria)13株,檢出率為6.40%。在2009/2010監(jiān)測年度,烏魯木齊市暴發(fā)新甲型H1N1疫情,共采集流感樣標(biāo)本1218份,其中檢出流感病毒陽性株504株,454株為新甲型H1N1,8株A1(H1N1)亞型株,12株為A3(H3N2),30株B (Victoria),檢出率為41.38%；病毒分離率以2009/2010監(jiān)測年度最高。2、三年度0～19歲的流感病毒株陽性率不同,其中2009/2010年度流感病毒陽性株高于2007/2008,2008/2009年度。2009/2010年度各年齡組比較無統(tǒng)計學(xué)差異(χ2=8.895,P=0.113)。通過分別對三個年度不同性別之間的流感病毒陽性率間無統(tǒng)計學(xué)差異(P值均大于0.05)。3、通過對三個監(jiān)測年度流感病毒陽性株時間分布分析,2007/2008年度陽性毒株的檢出高峰為2007年11月,2008/2009年度陽性毒株的檢出高峰為2008年11月和12月,2009/2010年度陽性毒株的檢出高峰為2009年10月、11月和12月。結(jié)論：通過流感病毒監(jiān)測系統(tǒng)對烏魯木齊市2007-2010監(jiān)測年度分析發(fā)現(xiàn),烏魯木齊市流感活動高峰時間為每年的冬季和春季,并且各年度流感流行的優(yōu)勢株也會不停的變化。1、2007/2008年度流感流行的優(yōu)勢株是B型(Yamagata系),2008/2009年度流行的優(yōu)勢株為B型(Victoria系),2009/2010年度因新甲型H1N1的爆發(fā)全部轉(zhuǎn)換為新甲型H1N1,但是等疫情過后流感亞型趨近于正常,優(yōu)勢株為B(Victoria)亞型。2、三個年度0～19歲的流感病毒株陽性率不同。三個年度不同性別之間的流感病毒陽性率間無統(tǒng)計學(xué)差異。3、烏魯木齊市從2007年開始流感病毒的優(yōu)勢株為B型,且優(yōu)勢一直并持續(xù)至2008/2009年度,B型毒株的流行時間與全國其他地區(qū)流行期來臨的時間基本一致。4、樣本的采集質(zhì)量嚴(yán)重影響病毒分離率,采集合格的樣本是病毒分離的基礎(chǔ)；5、烏魯木齊市流感流行規(guī)律與我國北方地區(qū)的流感流行規(guī)律基本吻合,主要體現(xiàn)在流行類型及優(yōu)勢株轉(zhuǎn)換基本相同,流行高峰時段與北方其他省市基本同步。根據(jù)流感毒株變化趨勢發(fā)現(xiàn)每年引起春季流感暴發(fā)的流行株會成為當(dāng)年冬季流感流行的優(yōu)勢株,因此預(yù)測2010～2011年度流感流行優(yōu)勢株可能為B (Victoria)亞型。
[Abstract]:Objective: to probe into the epidemic law of influenza in Urumqi, and to facilitate the prevention and control of influenza. It also lays a foundation for the prevention and control of influenza virus mutation in Urumqi. Methods: the pathogen of Urumqi Influenza in 2007 / 2010 was monitored by China Influenza Center Influenza Surveillance system. Results: based on the analysis of influenza surveillance data from 2007 to 2010 in Urumqi, we found that: 1 in 2007 / 2008 surveillance year, a total of 127 influenza-like cases were collected, of which 1 strain of influenza virus B (Victoria strain) and 6 strains of type B (Yamagata) were detected. The detection rate was 5.51%. In the surveillance year of 2008 / 2009, 203 samples of influenza like cases were collected, of which 13 strains of influenza virus were found to be type B (Victoria), and the detection rate was 6.40%. In the surveillance year of 2009 / 2010, a new type A H1N1 outbreak occurred in Urumqi. A total of 1218 influenza samples were collected, of which 504 were positive for influenza virus, 454 were new A1 (H1N1) subtype, 12 were A3 (H3N2). The positive rate of 30 B (Victoria), strains was 41.38; The virus isolation rate was the highest in 2009 / 2010 surveillance year. 2. The positive rate of influenza virus strain 0 / 19 years old in three years was different. The number of influenza virus positive strains in 2009 / 2010 was higher than that in 2007 / 2008 / 2008 / 2009. There was no significant difference among all age groups in 2009 / 2010 (蠂 ~ 2 / 8.895% P ~ (0.113). There was no significant difference in the positive rate of influenza virus among the three years (P > 0.05). 3. The time distribution of the positive strains of influenza virus was analyzed. The peak of positive strains in 2007 / 2008 was November 2007, the peak of positive strains in 2008 / 2009 was November and December 2008, and the peak of positive strains in 2009 / 2010 was October, November and December 2009. Conclusion: the annual analysis of influenza virus surveillance system in Urumqi from 2007 to 2010 shows that the peak time of influenza activity in Urumqi is winter and spring every year. The dominant strains of influenza epidemic in 2007 / 2008 were type B (Yamagata strain), and the dominant strains in 2008 / 2009 were type B (Victoria strain). In 2009 / 2010, due to the outbreak of new type A H1N1, all of them were transformed into new type A H1N1, but after the outbreak, the influenza subtype approached to normal, the dominant strain was B (Victoria) subtype. 2. The positive rate of influenza virus strains aged 0 or 19 years in three years was different. There is no statistical difference in the positive rate of influenza virus between sexes in three years. 3. In Urumqi, the dominant strain of influenza virus has been type B since 2007, and the dominant strain has continued until 2008 / 2009. The epidemic time of B strain was basically the same as that of other regions in China. 4. The collection quality of samples seriously affected the virus isolation rate, and the collection of qualified samples was the basis of virus isolation. 5. The epidemic pattern of influenza in Urumqi is basically consistent with that of the north of China, which is mainly reflected in the same epidemic type and dominant plant conversion, and the epidemic peak period is basically in sync with other provinces and cities in the north. According to the trend of influenza virus strain, it is found that the epidemic strain that causes spring influenza outbreak will become the dominant strain of winter influenza epidemic in that year, so it is predicted that the dominant influenza epidemic strain in 2010 / 2011 may be B (Victoria) subtype.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R181.3
本文編號：2426535
[Abstract]:Objective: to probe into the epidemic law of influenza in Urumqi, and to facilitate the prevention and control of influenza. It also lays a foundation for the prevention and control of influenza virus mutation in Urumqi. Methods: the pathogen of Urumqi Influenza in 2007 / 2010 was monitored by China Influenza Center Influenza Surveillance system. Results: based on the analysis of influenza surveillance data from 2007 to 2010 in Urumqi, we found that: 1 in 2007 / 2008 surveillance year, a total of 127 influenza-like cases were collected, of which 1 strain of influenza virus B (Victoria strain) and 6 strains of type B (Yamagata) were detected. The detection rate was 5.51%. In the surveillance year of 2008 / 2009, 203 samples of influenza like cases were collected, of which 13 strains of influenza virus were found to be type B (Victoria), and the detection rate was 6.40%. In the surveillance year of 2009 / 2010, a new type A H1N1 outbreak occurred in Urumqi. A total of 1218 influenza samples were collected, of which 504 were positive for influenza virus, 454 were new A1 (H1N1) subtype, 12 were A3 (H3N2). The positive rate of 30 B (Victoria), strains was 41.38; The virus isolation rate was the highest in 2009 / 2010 surveillance year. 2. The positive rate of influenza virus strain 0 / 19 years old in three years was different. The number of influenza virus positive strains in 2009 / 2010 was higher than that in 2007 / 2008 / 2008 / 2009. There was no significant difference among all age groups in 2009 / 2010 (蠂 ~ 2 / 8.895% P ~ (0.113). There was no significant difference in the positive rate of influenza virus among the three years (P > 0.05). 3. The time distribution of the positive strains of influenza virus was analyzed. The peak of positive strains in 2007 / 2008 was November 2007, the peak of positive strains in 2008 / 2009 was November and December 2008, and the peak of positive strains in 2009 / 2010 was October, November and December 2009. Conclusion: the annual analysis of influenza virus surveillance system in Urumqi from 2007 to 2010 shows that the peak time of influenza activity in Urumqi is winter and spring every year. The dominant strains of influenza epidemic in 2007 / 2008 were type B (Yamagata strain), and the dominant strains in 2008 / 2009 were type B (Victoria strain). In 2009 / 2010, due to the outbreak of new type A H1N1, all of them were transformed into new type A H1N1, but after the outbreak, the influenza subtype approached to normal, the dominant strain was B (Victoria) subtype. 2. The positive rate of influenza virus strains aged 0 or 19 years in three years was different. There is no statistical difference in the positive rate of influenza virus between sexes in three years. 3. In Urumqi, the dominant strain of influenza virus has been type B since 2007, and the dominant strain has continued until 2008 / 2009. The epidemic time of B strain was basically the same as that of other regions in China. 4. The collection quality of samples seriously affected the virus isolation rate, and the collection of qualified samples was the basis of virus isolation. 5. The epidemic pattern of influenza in Urumqi is basically consistent with that of the north of China, which is mainly reflected in the same epidemic type and dominant plant conversion, and the epidemic peak period is basically in sync with other provinces and cities in the north. According to the trend of influenza virus strain, it is found that the epidemic strain that causes spring influenza outbreak will become the dominant strain of winter influenza epidemic in that year, so it is predicted that the dominant influenza epidemic strain in 2010 / 2011 may be B (Victoria) subtype.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R181.3
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