福建省沿海地區(qū)居民PG、G-17及H.pylori抗體血清流行病學調查
發(fā)布時間:2018-11-15 20:25
【摘要】:目的研究血清胃蛋白酶原(Pepsinogen,PG)、胃泌素-17(Gastrin-17,G-17)和幽門螺桿菌(Helicobacter pylori,H.pylori)抗體在福建省沿海地區(qū)居民中的分布特征,探討這些血清學指標用于該省人群胃癌早期篩查的可能性。方法采用多階段分層隨機抽樣方法在長樂江田鎮(zhèn)、同安大同鎮(zhèn)和福安賽歧鎮(zhèn)選擇當?shù)鼐用駷檎{查對象,以ELISA法檢測血清PGⅠ、PGⅡ、G-17和H.pylori抗體,用中位數(shù)和率描述上述指標的分布特征,并用秩和檢驗、卡方檢驗和多重線性回歸分析方法進行統(tǒng)計學分析。結果 PGⅠ、PGⅡ、PGⅠ/Ⅱ比值(PGR)、G-17的中位數(shù)水平分別為113.75μg/L、12.0μg/L、9.89、1.4 pmol/L,H.pylori感染率為37.1%。男性PGⅠ、PGⅡ水平顯著高于女性,PGⅡ隨年齡增加而升高,有胃癌家族史居民G-17水平顯著高于無家族史者,長樂江田鎮(zhèn)H.pylori感染率顯著高于其他兩地,PGⅠ、PGⅡ、PGR和G-17水平在不同調查地區(qū)和H.pylori感染人群中的差異均有統(tǒng)計學意義。結論福建省沿海地區(qū)居民血清PGⅠ、PGⅡ、G-17和H.pylori抗體水平在不同性別、年齡、胃癌家族史和調查地區(qū)上可能存在差異。
[Abstract]:Objective to study the distribution of serum pepsinogen (Pepsinogen,PG), gastrin-17 (Gastrin-17,G-17) and Helicobacter pylori (Helicobacter pylori,H.pylori) antibodies in the coastal areas of Fujian Province. To explore the possibility of using these serological markers for early gastric cancer screening in the population of the province. Methods using multi-stage stratified random sampling method, the local residents were selected from Changle Jiangtian Town, Tongan Datong Town and Fu'an Seiqi Town. The serum PG 鈪,
本文編號:2334358
[Abstract]:Objective to study the distribution of serum pepsinogen (Pepsinogen,PG), gastrin-17 (Gastrin-17,G-17) and Helicobacter pylori (Helicobacter pylori,H.pylori) antibodies in the coastal areas of Fujian Province. To explore the possibility of using these serological markers for early gastric cancer screening in the population of the province. Methods using multi-stage stratified random sampling method, the local residents were selected from Changle Jiangtian Town, Tongan Datong Town and Fu'an Seiqi Town. The serum PG 鈪,
本文編號:2334358
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