發(fā)布時(shí)間：2018-10-05 06:47

【摘要】：目的比較Salk株脊髓灰質(zhì)炎(脊灰)滅活疫苗(IPV)、Sabin株IPV、三價(jià)口服脊灰減毒活疫苗(t OPV)、二價(jià)脊灰減毒活疫苗(b OPV)疑似預(yù)防接種異常反應(yīng)(AEFI)發(fā)生率,初步評(píng)價(jià)疫苗安全性。方法通過中國和吉林省免疫規(guī)劃信息管理系統(tǒng)收集吉林省2016年4種脊灰疫苗AEFI個(gè)案和接種劑次數(shù),計(jì)算AEFI報(bào)告發(fā)生率。結(jié)果吉林省IPV(Salk)、IPV(Sabin)、t OPV和b OPV AEFI發(fā)生率分別為162.80/10萬、168.91/10萬、44.06/10萬和39.85/10萬。IPV(Salk)和IPV(Sabin)、t OPV和b OPV的AEFI發(fā)生率均無顯著性差異;IPV(Salk)和t OPV(χ~2=22.99,P0.05)、IPV(Salk)和b OPV(χ~2=31.55,P0.05)、IPV(Sabin)和t OPV(χ~2=93.11,P0.05)、IPV(Sabin)和b OPV(χ~2=228.30,P0.05)AEFI發(fā)生率均有顯著性差異。結(jié)論 4種脊灰疫苗總體安全性好;IPV(Salk)和IPV(Sabin)AEFI發(fā)生率高于b OPV和t OPV,進(jìn)口IPV(Salk)和國產(chǎn)IPV(Sabin)安全性一致。
[Abstract]:Objective to compare the incidence of suspected abnormal vaccination of Salk strain poliomyelitis (IPV) inactivated (IPV) Sabin strain IPV, trivalent oral attenuated poliomyelitis vaccine (t OPV), divalent live attenuated (t OPV), vaccine (b OPV), and to evaluate the safety of the vaccine. Methods four polio vaccine AEFI cases and times of inoculation were collected by China and Jilin Province Immunization Planning Information Management system in 2016, and the reported incidence of AEFI was calculated. 緇撴灉鍚夋灄鐪両PV(Salk),IPV(Sabin),t OPV鍜宐 OPV AEFI鍙戠敓鐜囧垎鍒負(fù)162.80/10涓，

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