【摘要】：嚴(yán)重急性呼吸道綜合征(Severe Acute Respiratory Syndrome,SARS)是新出現(xiàn)的一種人類(lèi)傳染病,2003年4月15日,天津某醫(yī)院一例輸入性病例引發(fā)了該醫(yī)院SARS爆發(fā)流行。利用該醫(yī)院爆發(fā)流行現(xiàn)場(chǎng),調(diào)查和研究SARS醫(yī)院內(nèi)爆發(fā)流行的特點(diǎn);研究SARS患者康復(fù)期血清冠狀病毒抗體變化規(guī)律;了解疫區(qū)內(nèi)人群血清SARS冠狀病毒抗體水平以及是否存在隱性感染。 目的:通過(guò)醫(yī)院內(nèi)SARS爆發(fā)疫情的描述性研究,了解醫(yī)院內(nèi)SARS爆發(fā)流行的特點(diǎn)、規(guī)律,同時(shí)評(píng)價(jià)院內(nèi)感染控制措施的效果;通過(guò)SARS爆發(fā)流行疫源地血清流行病學(xué)研究,動(dòng)態(tài)觀察SARS人群康復(fù)后不同時(shí)間血清冠狀病毒抗體變化規(guī)律,觀察疫情前后非SARS人群SARS冠狀病毒IgG抗體免疫水平,闡明SARS人群血清冠狀病毒抗體變化規(guī)律,SARS是否存在隱性感染等,為SARS診斷和預(yù)防與控制提供理論依據(jù)。 方法:采用描述性流行病學(xué)方法研究醫(yī)院內(nèi)SARS爆發(fā)流行的特點(diǎn)、規(guī)律;采用前瞻性流行病學(xué)研究的方法研究SARS疫源地血清流行病學(xué)特點(diǎn)。 結(jié)果: 1 醫(yī)院內(nèi)SARS爆發(fā)的描述性研究結(jié)果顯示: (1)一例輸入性傳染源引發(fā)了該醫(yī)院的SARS疫情,由于早期缺乏防護(hù)意識(shí)和有效防控措施導(dǎo)致了SARS疫情在醫(yī)院內(nèi)的傳播、蔓延;(2)此次醫(yī)院內(nèi)SARS爆發(fā)流行發(fā)生三代病例,累計(jì)88例,被感染者發(fā)病時(shí)間集中在疫情出現(xiàn)后的第4到第8天(4月20日-4月24日),人群分布特點(diǎn)表現(xiàn)為女性多于男性,年齡集中在20-45歲,醫(yī)院工作人員中護(hù)士和醫(yī)生感染比例較高;在科室分布上,感染者集中在指示病例所在科室,并以此為中心,向四周科室和部門(mén)輻射;電
[Abstract]:Severe Acute Respiratory Syndrome (Severe Acute Respiratory Syndrome,SARS) is a new human infectious disease. On April 15, 2003, an imported case caused the outbreak of SARS in Tianjin Hospital. To investigate and study the characteristics of epidemic outbreak in SARS hospital, to investigate the changes of serum coronavirus antibodies in patients with SARS during convalescence. To know the level of serum SARS coronavirus antibody and whether there is recessive infection. Objective: to understand the characteristics and regularity of SARS outbreak in hospital, to evaluate the effect of nosocomial infection control measures, and to study the seroepidemiology of SARS epidemic foci by means of descriptive study on the outbreak of SARS in hospital. The changes of serum coronavirus antibody and the immune level of SARS coronavirus IgG antibody were observed at different time after rehabilitation in SARS population. To elucidate the changes of serum coronavirus antibodies in SARS population and to provide theoretical basis for the diagnosis, prevention and control of SARS. Methods: descriptive epidemiological method was used to study the characteristics and regularity of SARS outbreak in hospitals, and prospective epidemiological study was used to study the seroepidemiological characteristics of SARS foci. Results: 1 descriptive study of SARS outbreak in hospital showed that: (1) an imported source of infection caused the SARS epidemic in the hospital. The early lack of awareness of protection and effective prevention and control measures led to the spread and spread of SARS in hospitals. (2) there were three generations of SARS outbreaks in hospitals, a total of 88 cases. The incidence time of the infected patients was from the 4th to the 8th day (April 20-April 24). The distribution of the population was more female than male, the age was 20-45 years old, the proportion of nurses and doctors infection was higher in hospital staff. In the distribution of departments, the infected people concentrated in the department where the indicative case is located, and this as the center, radiation to the four departments and departments; electricity;
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類(lèi)號(hào)】：R181.3

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